Table 4.

Multivariate analyses


Risk factor

Adjusted HR

95% CI

P
TRM     
    Donor relation     
        Sibling   (1)   1.0-3.5   .05  
        VUD   1.9    
    MTX     
        No   (1)   0.3-0.97   .04  
        Yes   0.56    
Relapse risk     
    Donor relation     
        Sibling   (1)   0.19-0.76   < .01  
        VUD   0.38    
    Stage     
        CP1   (1)   1.36-4.3   < .01  
        AP   2.4    
    T-cell depletion     
        No   (1)   0.98-3.3   .06  
        Yes   1.8    
Overall survival     
    Stage     
        CP1   (1)   1.3-3.0   < .01  
        AP   2.0    
    MTX     
        No   (1)   0.38-0.97   .038  
        Yes   0.6    
LFS     
    Stage     
        CP1   (1)   1.2-2.6   < .01  
        AP   1.8    
    T-cell depletion     
        No   (1)   0.98-2.2   .064  
        Yes   1.46    
    Interval diagnosis to SCT     
        0-6 mo   (1)   -   -  
        6-12 mo   1.6   1.0-2.5   .037  
        > 12 mo
 
1.5
 
0.98-2.4
 
.064
 

Risk factor

Adjusted HR

95% CI

P
TRM     
    Donor relation     
        Sibling   (1)   1.0-3.5   .05  
        VUD   1.9    
    MTX     
        No   (1)   0.3-0.97   .04  
        Yes   0.56    
Relapse risk     
    Donor relation     
        Sibling   (1)   0.19-0.76   < .01  
        VUD   0.38    
    Stage     
        CP1   (1)   1.36-4.3   < .01  
        AP   2.4    
    T-cell depletion     
        No   (1)   0.98-3.3   .06  
        Yes   1.8    
Overall survival     
    Stage     
        CP1   (1)   1.3-3.0   < .01  
        AP   2.0    
    MTX     
        No   (1)   0.38-0.97   .038  
        Yes   0.6    
LFS     
    Stage     
        CP1   (1)   1.2-2.6   < .01  
        AP   1.8    
    T-cell depletion     
        No   (1)   0.98-2.2   .064  
        Yes   1.46    
    Interval diagnosis to SCT     
        0-6 mo   (1)   -   -  
        6-12 mo   1.6   1.0-2.5   .037  
        > 12 mo
 
1.5
 
0.98-2.4
 
.064
 

All multivariate models included the following factors: donor relationship, stage of disease at transplantation, donor/recipient sex mismatch, time interval between diagnosis and transplantation, calendar year of SCT, and GVHD prophylaxis. Data were available for all 314 children in the study for all variables. Only the significant factors for each outcome are reported.

CMV serostatus and the use of IFN-α before SCT were initially excluded from the multivariate models because their data sets were incomplete. Their influences on outcome were analyzed separately and are described separately in “Leukemia-free survival.”

Adjusted HR indicates that each risk factor is adjusted for all other factors in the same model.

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