Multivariate analyses
Risk factor . | Adjusted HR . | 95% CI . | P . |
---|---|---|---|
TRM | |||
Donor relation | |||
Sibling | (1) | 1.0-3.5 | .05 |
VUD | 1.9 | ||
MTX | |||
No | (1) | 0.3-0.97 | .04 |
Yes | 0.56 | ||
Relapse risk | |||
Donor relation | |||
Sibling | (1) | 0.19-0.76 | < .01 |
VUD | 0.38 | ||
Stage | |||
CP1 | (1) | 1.36-4.3 | < .01 |
AP | 2.4 | ||
T-cell depletion | |||
No | (1) | 0.98-3.3 | .06 |
Yes | 1.8 | ||
Overall survival | |||
Stage | |||
CP1 | (1) | 1.3-3.0 | < .01 |
AP | 2.0 | ||
MTX | |||
No | (1) | 0.38-0.97 | .038 |
Yes | 0.6 | ||
LFS | |||
Stage | |||
CP1 | (1) | 1.2-2.6 | < .01 |
AP | 1.8 | ||
T-cell depletion | |||
No | (1) | 0.98-2.2 | .064 |
Yes | 1.46 | ||
Interval diagnosis to SCT | |||
0-6 mo | (1) | - | - |
6-12 mo | 1.6 | 1.0-2.5 | .037 |
> 12 mo | 1.5 | 0.98-2.4 | .064 |
Risk factor . | Adjusted HR . | 95% CI . | P . |
---|---|---|---|
TRM | |||
Donor relation | |||
Sibling | (1) | 1.0-3.5 | .05 |
VUD | 1.9 | ||
MTX | |||
No | (1) | 0.3-0.97 | .04 |
Yes | 0.56 | ||
Relapse risk | |||
Donor relation | |||
Sibling | (1) | 0.19-0.76 | < .01 |
VUD | 0.38 | ||
Stage | |||
CP1 | (1) | 1.36-4.3 | < .01 |
AP | 2.4 | ||
T-cell depletion | |||
No | (1) | 0.98-3.3 | .06 |
Yes | 1.8 | ||
Overall survival | |||
Stage | |||
CP1 | (1) | 1.3-3.0 | < .01 |
AP | 2.0 | ||
MTX | |||
No | (1) | 0.38-0.97 | .038 |
Yes | 0.6 | ||
LFS | |||
Stage | |||
CP1 | (1) | 1.2-2.6 | < .01 |
AP | 1.8 | ||
T-cell depletion | |||
No | (1) | 0.98-2.2 | .064 |
Yes | 1.46 | ||
Interval diagnosis to SCT | |||
0-6 mo | (1) | - | - |
6-12 mo | 1.6 | 1.0-2.5 | .037 |
> 12 mo | 1.5 | 0.98-2.4 | .064 |
All multivariate models included the following factors: donor relationship, stage of disease at transplantation, donor/recipient sex mismatch, time interval between diagnosis and transplantation, calendar year of SCT, and GVHD prophylaxis. Data were available for all 314 children in the study for all variables. Only the significant factors for each outcome are reported.
CMV serostatus and the use of IFN-α before SCT were initially excluded from the multivariate models because their data sets were incomplete. Their influences on outcome were analyzed separately and are described separately in “Leukemia-free survival.”
Adjusted HR indicates that each risk factor is adjusted for all other factors in the same model.