Results of proportional hazards modeling for the development of grade III to IV acute GVHD
. | Relative risk (95% CI) . | P . |
|---|---|---|
| Serologic matching | ||
| Age | ||
| Younger than 40 y | 1.00 | .027 |
| 40 y and older | 1.36 (1.04-1.79) | |
| Disease | ||
| Standard risk | 1.00 | .015 |
| High risk | 1.43 (1.07-1.92) | |
| Sex | ||
| Female | 1.00 | < .0001 |
| Male | 1.86 (1.37-2.53) | |
| Stem cell | ||
| BMT | 1.00 | < .0001 |
| PBSCT | 2.24 (1.63-3.08) | |
| HLA | ||
| GVH match | 1.00 | < .0001 |
| GVH mismatch | 2.67 (1.65-4.33) | |
| Genotypic matching | ||
| Age | ||
| Younger than 40 y | 1.00 | .041 |
| 40 y and older | 1.34 (1.01-1.78) | |
| Disease | ||
| Standard risk | 1.00 | .024 |
| High risk | 1.41 (1.01-1.90) | |
| Sex | ||
| Female | 1.00 | .0002 |
| Male | 1.81 (1.33-2.48) | |
| Stem cell | ||
| BMT | 1.00 | < .0001 |
| PBSCT | 2.47 (1.79-3.41) | |
| HLA | ||
| GVH match | 1.00 | < .0001 |
| GVH mismatch | 5.41 (2.93-10.0) |
. | Relative risk (95% CI) . | P . |
|---|---|---|
| Serologic matching | ||
| Age | ||
| Younger than 40 y | 1.00 | .027 |
| 40 y and older | 1.36 (1.04-1.79) | |
| Disease | ||
| Standard risk | 1.00 | .015 |
| High risk | 1.43 (1.07-1.92) | |
| Sex | ||
| Female | 1.00 | < .0001 |
| Male | 1.86 (1.37-2.53) | |
| Stem cell | ||
| BMT | 1.00 | < .0001 |
| PBSCT | 2.24 (1.63-3.08) | |
| HLA | ||
| GVH match | 1.00 | < .0001 |
| GVH mismatch | 2.67 (1.65-4.33) | |
| Genotypic matching | ||
| Age | ||
| Younger than 40 y | 1.00 | .041 |
| 40 y and older | 1.34 (1.01-1.78) | |
| Disease | ||
| Standard risk | 1.00 | .024 |
| High risk | 1.41 (1.01-1.90) | |
| Sex | ||
| Female | 1.00 | .0002 |
| Male | 1.81 (1.33-2.48) | |
| Stem cell | ||
| BMT | 1.00 | < .0001 |
| PBSCT | 2.47 (1.79-3.41) | |
| HLA | ||
| GVH match | 1.00 | < .0001 |
| GVH mismatch | 5.41 (2.93-10.0) |
Two- or 3-loci—mismatched transplants were excluded. BMT indicates bone marrow transplantation; PBSCT, peripheral blood stem cell transplantation.