Baseline levels of variables before administration of any drug
. | Placebo, mean (± 95% CI); n = 9 . | rhAPC, mean (± 95% CI); n = 15 . |
|---|---|---|
| APC, ng/mL | 1.01 (0.93-1.08) | 1.02 (0.94-1.10) |
| PC:Act, U/mL | 1.11 (0.96-1.27) | 1.19 (1.09-1.30) |
| PC:Ag, U/mL | 0.99 (0.81-1.17) | 1.05 (0.95-1.15) |
| aPTT, s | 35.3 (34.1-36.5) | 34.6 (33.0-36.2) |
| Tissue factor mRNA, cycles | 34.0 (33.4-34.6) | 34.4 (33.8-35.0) |
| TAT, μg/L | 2.01 (<1.9-2.17) | 2.09 (<1.9-2.37) |
| F1 + 2, nM | 0.62 (0.47-0.77) | 0.62 (0.56-0.68) |
| d-dimer, μg/L | 0.16 (0.10-0.22) | 0.22 (0.15-0.30) |
| PAP, μg/mL | 281 (206-356) | 277 (233-321) |
| tPA, ng/mL | 1.74 (0.93-2.54) | 2.92 (1.09-4.76) |
| PAI-1, ng/mL | 7.8 (5.0-10.6) | 11.0 (6.7-15.4) |
| TNF-α, pg/mL | 0.64 (0.41-0.86) | 0.57 (0.51-0.63) |
| IL-6, pg/mL | 4.09 (0.06-8.25) | 2.55 (1.65-3.45) |
| Elastase, pg/mL | 10.8 (7.5-14.0) | 10.5 (8.7-12.2) |
| E-selectin, ng/mL | 29.9 (24.4-35.4) | 39.1 (30.1-48.1) |
| P-selectin, ng/mL | 32.1 (26.0-38.1) | 41.6 (35.4-47.9) |
| Hemoglobin, g/L | 147 (140-154) | 145 (140-151) |
| Platelet count, × 109/L | 208 (172-243) | 216 (193-240) |
| Neutrophil count, × 109/L | 2.95 (1.84-4.05) | 2.77 (2.29-3.25) |
| Monocyte count, × 109/L | 0.42 (0.27-0.57) | 0.40 (0.31-0.48) |
| Lymphocyte count, × 109/L | 1.85 (1.52-2.17) | 2.26 (1.97-2.55) |
| Heart rate, beats per min-1 | 64 (54-74) | 72 (65-78) |
| Systolic blood pressure, mm Hg | 123 (116-130) | 126 (122-131) |
| Diastolic blood pressure, mm Hg | 60 (55-66) | 65 (61-69) |
. | Placebo, mean (± 95% CI); n = 9 . | rhAPC, mean (± 95% CI); n = 15 . |
|---|---|---|
| APC, ng/mL | 1.01 (0.93-1.08) | 1.02 (0.94-1.10) |
| PC:Act, U/mL | 1.11 (0.96-1.27) | 1.19 (1.09-1.30) |
| PC:Ag, U/mL | 0.99 (0.81-1.17) | 1.05 (0.95-1.15) |
| aPTT, s | 35.3 (34.1-36.5) | 34.6 (33.0-36.2) |
| Tissue factor mRNA, cycles | 34.0 (33.4-34.6) | 34.4 (33.8-35.0) |
| TAT, μg/L | 2.01 (<1.9-2.17) | 2.09 (<1.9-2.37) |
| F1 + 2, nM | 0.62 (0.47-0.77) | 0.62 (0.56-0.68) |
| d-dimer, μg/L | 0.16 (0.10-0.22) | 0.22 (0.15-0.30) |
| PAP, μg/mL | 281 (206-356) | 277 (233-321) |
| tPA, ng/mL | 1.74 (0.93-2.54) | 2.92 (1.09-4.76) |
| PAI-1, ng/mL | 7.8 (5.0-10.6) | 11.0 (6.7-15.4) |
| TNF-α, pg/mL | 0.64 (0.41-0.86) | 0.57 (0.51-0.63) |
| IL-6, pg/mL | 4.09 (0.06-8.25) | 2.55 (1.65-3.45) |
| Elastase, pg/mL | 10.8 (7.5-14.0) | 10.5 (8.7-12.2) |
| E-selectin, ng/mL | 29.9 (24.4-35.4) | 39.1 (30.1-48.1) |
| P-selectin, ng/mL | 32.1 (26.0-38.1) | 41.6 (35.4-47.9) |
| Hemoglobin, g/L | 147 (140-154) | 145 (140-151) |
| Platelet count, × 109/L | 208 (172-243) | 216 (193-240) |
| Neutrophil count, × 109/L | 2.95 (1.84-4.05) | 2.77 (2.29-3.25) |
| Monocyte count, × 109/L | 0.42 (0.27-0.57) | 0.40 (0.31-0.48) |
| Lymphocyte count, × 109/L | 1.85 (1.52-2.17) | 2.26 (1.97-2.55) |
| Heart rate, beats per min-1 | 64 (54-74) | 72 (65-78) |
| Systolic blood pressure, mm Hg | 123 (116-130) | 126 (122-131) |
| Diastolic blood pressure, mm Hg | 60 (55-66) | 65 (61-69) |