Clinico-biologic characteristics of pro-B-ALL patients grouped according to the 3 genotypic subtypes
. | . | 1 . | 2 . | . | 3 . | . |
|---|---|---|---|---|---|---|
| Features . | Total no. of patients (%), n = 66 . | ALL1/AF4-positive (%), n = 24 . | ALL1/AF4-BCR/ABL-negative (%), n = 36 . | P, 1 vs 2 . | BCR/ABL-positive (%), n = 6 . | P, 1 vs 2 vs 3 . |
| Sex | NS | NS | ||||
| M | 32 (48) | 13 (54) | 15 (42) | 4 (67) | ||
| F | 34 (52) | 11 (46) | 21 (58) | 2 (33) | ||
| Age | NS | NS | ||||
| 16 y to 30 y | 29 (44) | 7 (29) | 20 (56) | 2 (33) | ||
| 31 y to 50 y | 30 (45) | 14 (58) | 14 (39) | 2 (33) | ||
| 51 y to 60 y | 7 (11) | 3 (13) | 2 (5) | 2 (33) | ||
| WBC count | .001 | .001 | ||||
| 50 × 109/L or lower | 45 (68) | 11 (46) | 30 (83) | 4 (67) | ||
| Higher than 50 × 109/L | 21 (32) | 13 (54) | 6 (17) | 2 (33) | ||
| CD13 | .0001 | .0001 | ||||
| Positive | 17 (27) | 0 (0) | 14 (42) | 3 (50) | ||
| Negative | 46 (73) | 24 (100) | 19 (58) | 3 (50) | ||
| CD33 | .007 | .007 | ||||
| Positive | 11 (17) | 0 (0) | 9 (26) | 2 (33) | ||
| Negative | 53 (83) | 23 (100) | 26 (74) | 4 (67) | ||
| CD34 | .00006 | .00006 | ||||
| Positive | 44 (64) | 10 (42) | 33 (92) | 5 (83) | ||
| Negative | 22 (33) | 14 (58) | 3 (8) | 1 (17) |
. | . | 1 . | 2 . | . | 3 . | . |
|---|---|---|---|---|---|---|
| Features . | Total no. of patients (%), n = 66 . | ALL1/AF4-positive (%), n = 24 . | ALL1/AF4-BCR/ABL-negative (%), n = 36 . | P, 1 vs 2 . | BCR/ABL-positive (%), n = 6 . | P, 1 vs 2 vs 3 . |
| Sex | NS | NS | ||||
| M | 32 (48) | 13 (54) | 15 (42) | 4 (67) | ||
| F | 34 (52) | 11 (46) | 21 (58) | 2 (33) | ||
| Age | NS | NS | ||||
| 16 y to 30 y | 29 (44) | 7 (29) | 20 (56) | 2 (33) | ||
| 31 y to 50 y | 30 (45) | 14 (58) | 14 (39) | 2 (33) | ||
| 51 y to 60 y | 7 (11) | 3 (13) | 2 (5) | 2 (33) | ||
| WBC count | .001 | .001 | ||||
| 50 × 109/L or lower | 45 (68) | 11 (46) | 30 (83) | 4 (67) | ||
| Higher than 50 × 109/L | 21 (32) | 13 (54) | 6 (17) | 2 (33) | ||
| CD13 | .0001 | .0001 | ||||
| Positive | 17 (27) | 0 (0) | 14 (42) | 3 (50) | ||
| Negative | 46 (73) | 24 (100) | 19 (58) | 3 (50) | ||
| CD33 | .007 | .007 | ||||
| Positive | 11 (17) | 0 (0) | 9 (26) | 2 (33) | ||
| Negative | 53 (83) | 23 (100) | 26 (74) | 4 (67) | ||
| CD34 | .00006 | .00006 | ||||
| Positive | 44 (64) | 10 (42) | 33 (92) | 5 (83) | ||
| Negative | 22 (33) | 14 (58) | 3 (8) | 1 (17) |
NS indicates not significant.