Clinical and laboratory data of 64 patients with PV confirmed by WHO criteria
. | Sample . | . | Maximal value . | . | ||
|---|---|---|---|---|---|---|
. | Males . | Females . | Males . | Females . | ||
| Hemoglobin, g/L | 146 (89-206) | 148 (104-181) | 202 (186-240) | 188 (166-222) | ||
| Hematocrit, proportion of 1 | .48 (.31-.64) | .48 (.33-.58) | .63 (.55-.74) | .59 (.50-.76) | ||
| Leukocytes, 109/L | 13.8 (3.1-46) | 13.6 (4.2-37) | 18.8 (5.8-54) | 17.6 (6.4-37) | ||
| Platelets, 109/L | 385 (39-991) | 518 (96-1072) | 725 (192-1800) | 814 (151-1654) | ||
| Splenomegaly, no. of subjects | 15/30 | 14/26 | 25/35 | 19/29 | ||
. | Sample . | . | Maximal value . | . | ||
|---|---|---|---|---|---|---|
. | Males . | Females . | Males . | Females . | ||
| Hemoglobin, g/L | 146 (89-206) | 148 (104-181) | 202 (186-240) | 188 (166-222) | ||
| Hematocrit, proportion of 1 | .48 (.31-.64) | .48 (.33-.58) | .63 (.55-.74) | .59 (.50-.76) | ||
| Leukocytes, 109/L | 13.8 (3.1-46) | 13.6 (4.2-37) | 18.8 (5.8-54) | 17.6 (6.4-37) | ||
| Platelets, 109/L | 385 (39-991) | 518 (96-1072) | 725 (192-1800) | 814 (151-1654) | ||
| Splenomegaly, no. of subjects | 15/30 | 14/26 | 25/35 | 19/29 | ||
Left columns: data at the time of blood sampling. Right columns: maximal values observed at any time in the course of the disease. Numbers denote mean (range). Splenomegaly is defined by either a palpable spleen or a longitudinal diameter of more than 14 cm in abdominal ultrasound. At time of the sample, spleen size was not documented in 6 patients. Splenectomy had been performed in 2 patients.
There were 4 patients tested 19 to 32 years after diagnosis who had hemoglobin values less than 11.0 mg/mL at the time of analysis. All 4 had secondary myelofibrosis with a greatly enlarged spleen; 2 of these patients subsequently died from secondary acute myeloid leukemia.