Detection of FVIII(V) vector in PBMCs
. | . | Week . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|
| Dose group . | Dose, TU/kg . | 4 . | 13 . | 29 . | 53 . | |||
| 1 | 2.8 × 107 | 12/12 | 12/12 | 10/12 | 4/8 | |||
| 2 | 9.2 × 107 | 4/4 | 7/8 | 11/12 | 8/8 | |||
| 3 | 2.2 × 108 | ND | 8/8 | 12/12 | ND | |||
| 4 | 4.4 × 108 | 4/4 | 12/12 | 4/4 | ND | |||
| 5 | 8.8 × 108 | 4/4 | 4/4 | ND | ND | |||
. | . | Week . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|
| Dose group . | Dose, TU/kg . | 4 . | 13 . | 29 . | 53 . | |||
| 1 | 2.8 × 107 | 12/12 | 12/12 | 10/12 | 4/8 | |||
| 2 | 9.2 × 107 | 4/4 | 7/8 | 11/12 | 8/8 | |||
| 3 | 2.2 × 108 | ND | 8/8 | 12/12 | ND | |||
| 4 | 4.4 × 108 | 4/4 | 12/12 | 4/4 | ND | |||
| 5 | 8.8 × 108 | 4/4 | 4/4 | ND | ND | |||
Numbers represent the number of PCR assays positive over the number of assays performed. When tested, each subject's sample was tested with 4 replicate assays. Thus at week 13 for dose group 1, for example, there were 12 replicate assays, 4 from each of 3 subjects in the group.
PBMC indicates peripheral blood mononuclear cell; ND, assay not performed.