Table 1. Hemophilia A mice: dosages and... | American Society of Hematology

Table 1.

Hemophilia A mice: dosages and injection times of test and control substances

		Test substance and time of injection
Group	n	0 min	35 min
Control	16	NaCl^*	NaCl†
Hemophilia control	16	Anti-FVIII‡	NaCl†
Hemophilia/rFVIIa, 1 mg/kg	8	Anti-FVIII‡	rFVIIa§
Hemophilia/rFVIIa, 3 mg/kg	16	Anti-FVIII‡	rFVIIa§
Hemophilia/rFVIIa, 6 mg/kg	8	Anti-FVIII‡	rFVIIa§
Hemophilia/rFVIIa, 10 mg/kg	15	Anti-FVIII‡	rFVIIa§
Hemophilia/FVIIa_IIa, 1 mg/kg	14	Anti-FVIII‡	FVIIa_IIa§
Hemophilia/FVIIa_IIa, 3 mg/kg	8	Anti-FVIII‡	FVIIa_IIa§
Hemophilia/K337A-FVIIa_IIa, 1 mg/kg	6	Anti-FVIII‡	K337A-FVIIa_IIa§
Hemophilia/K337A-FVIIa_IIa, 3 mg/kg	5	Anti-FVIII‡	K337A-FVIIa_IIa§
Hemophilia/M298Q-FVIIa, 1 mg/kg	15	Anti-FVIII‡	M298Q-FVIIa§
Hemophilia/M298Q-FVIIa, 3 mg/kg	14	Anti-FVIII‡	M298Q-FVIIa§

		Test substance and time of injection
Group	n	0 min	35 min
Control	16	NaCl^*	NaCl†
Hemophilia control	16	Anti-FVIII‡	NaCl†
Hemophilia/rFVIIa, 1 mg/kg	8	Anti-FVIII‡	rFVIIa§
Hemophilia/rFVIIa, 3 mg/kg	16	Anti-FVIII‡	rFVIIa§
Hemophilia/rFVIIa, 6 mg/kg	8	Anti-FVIII‡	rFVIIa§
Hemophilia/rFVIIa, 10 mg/kg	15	Anti-FVIII‡	rFVIIa§
Hemophilia/FVIIa_IIa, 1 mg/kg	14	Anti-FVIII‡	FVIIa_IIa§
Hemophilia/FVIIa_IIa, 3 mg/kg	8	Anti-FVIII‡	FVIIa_IIa§
Hemophilia/K337A-FVIIa_IIa, 1 mg/kg	6	Anti-FVIII‡	K337A-FVIIa_IIa§
Hemophilia/K337A-FVIIa_IIa, 3 mg/kg	5	Anti-FVIII‡	K337A-FVIIa_IIa§
Hemophilia/M298Q-FVIIa, 1 mg/kg	15	Anti-FVIII‡	M298Q-FVIIa§
Hemophilia/M298Q-FVIIa, 3 mg/kg	14	Anti-FVIII‡	M298Q-FVIIa§

Illustrating the group sizes, dosages, and injection times of test and control substances.

3.3 mL 0.9% (wt/vol) NaCl/kg body weight.

10.0 mL 0.9% (wt/vol) NaCl/kg body weight.

4950 BU anti-FVIII/kg body weight ∼3.3 mL/kg body weight.

Reconstituted rFVIIa and analogs 10.0 mL/kg body weight.