Univariate matched odds ratios for a first spontaneous abortion between 8 and 10 weeks of pregnancy for traditional antiphospholipid antibodies
Biomarker . | Case patients (%) n = 743 . | Control patients (%) n = 743 . | Matched odds ratio . | 95% confidence interval . | P* . |
|---|---|---|---|---|---|
| Positive lupus anticoagulant activity | 48 (6.5) | 10 (1.3) | 4.8 | 2.4-9.5 | < .001 |
| Anticardiolipin Ig G, GPL units | .074 | ||||
| 0.2-9.3 | 569 (76.6) | 601 (80.9) | 1.0 | Reference | |
| 9.4-12.0 | 123 (16.6) | 104 (14.0) | 1.2 | 0.9-1.7 | |
| 12.2-21.7 | 47 (6.3) | 30 (4.0) | 1.6 | 1.0-2.6 | |
| Greater than 23.7 | 4 (0.5) | 8 (1.0) | 0.6 | 0.2-1.9 | |
| Anticardiolipin IgM, MPL units | < .001 | ||||
| 0.8-8.0 | 535 (72.0) | 602 (81.0) | 1.0 | Reference | |
| 8.1-11.0 | 140 (18.8) | 103 (13.9) | 1.6 | 1.2-2.2 | |
| 11.3-17.0 | 44 (5.9) | 29 (3.9) | 1.9 | 1.1-3.1 | |
| Greater than 17.5 | 24 (3.2) | 9 (1.2) | 3.0 | 1.4-6.6 |
Biomarker . | Case patients (%) n = 743 . | Control patients (%) n = 743 . | Matched odds ratio . | 95% confidence interval . | P* . |
|---|---|---|---|---|---|
| Positive lupus anticoagulant activity | 48 (6.5) | 10 (1.3) | 4.8 | 2.4-9.5 | < .001 |
| Anticardiolipin Ig G, GPL units | .074 | ||||
| 0.2-9.3 | 569 (76.6) | 601 (80.9) | 1.0 | Reference | |
| 9.4-12.0 | 123 (16.6) | 104 (14.0) | 1.2 | 0.9-1.7 | |
| 12.2-21.7 | 47 (6.3) | 30 (4.0) | 1.6 | 1.0-2.6 | |
| Greater than 23.7 | 4 (0.5) | 8 (1.0) | 0.6 | 0.2-1.9 | |
| Anticardiolipin IgM, MPL units | < .001 | ||||
| 0.8-8.0 | 535 (72.0) | 602 (81.0) | 1.0 | Reference | |
| 8.1-11.0 | 140 (18.8) | 103 (13.9) | 1.6 | 1.2-2.2 | |
| 11.3-17.0 | 44 (5.9) | 29 (3.9) | 1.9 | 1.1-3.1 | |
| Greater than 17.5 | 24 (3.2) | 9 (1.2) | 3.0 | 1.4-6.6 |
All the variables are divided into 4 categories: percentiles 1-80, 81-95, 96-99, and 100, except lupus anticoagulant which is dichotomous.
P- was determined for linear trend.