Univariate matched odds ratios for a first spontaneous abortion between 8 and 10 weeks of pregnancy for nontraditional antiphospholipid antibodies and homocysteine
Biomarker . | Case patients (%) n = 743 . | Control patients (%) n = 743 . | Matched odds ratio . | 95% confidence interval . | P* . |
|---|---|---|---|---|---|
| Antiphosphatidylethanolamine IgG by percentiles | .26 | ||||
| 1-80 | 572 (77.0) | 595 (80.0) | 1.0 | Reference | |
| 81-95 | 134 (18.0) | 111 (14.9) | 1.3 | 1.0-1.7 | |
| 96-99 | 28 (3.8) | 30 (4.0) | 1.0 | 0.6-1.7 | |
| 100 | 9 (1.2) | 7 (1.0) | 1.3 | 0.5-3.6 | |
| Antiphosphatidylethanolamine IgM by percentiles | < .001 | ||||
| 1-80 | 508 (68.4) | 596 (80.2) | 1.0 | Reference | |
| 81-95 | 147 (19.8) | 110 (14.8) | 1.6 | 1.2-2.0 | |
| 96-99 | 37 (5.0) | 28 (3.7) | 1.8 | 1.0-3.0 | |
| 100 | 51 (6.9) | 9 (1.2) | 6.6 | 3.2-13.6 | |
| Anti-β2-glycoprotein 1 IgG by percentiles | .001 | ||||
| 1-80 | 554 (74.6) | 595 (80.0) | 1.0 | Reference | |
| 81-95 | 128 (17.2) | 109 (14.7) | 1.3 | 1.0-1.7 | |
| 96-99 | 40 (5.4) | 31 (4.2) | 1.4 | 0.8-2.2 | |
| 100 | 21 (2.8) | 8 (1.0) | 2.8 | 1.2-6.4 | |
| Anti-β2-glycoprotein 1 IgM by percentiles | .32 | ||||
| 1-80 | 573 (77.1) | 595 (80.1) | 1.0 | Reference | |
| 81-95 | 136 (18.3) | 112 (15.1) | 1.2 | 1.0-1.6 | |
| 96-99 | 24 (3.2) | 29 (3.9) | 0.8 | 0.5-1.5 | |
| 100 | 10 (1.3) | 7 (0.9) | 1.4 | 0.6-3.8 | |
| Anti-annexin V IgG by percentiles | < .001 | ||||
| 1-80 | 533 (71.7) | 595 (80.1) | 1.0 | Reference | |
| 81-95 | 140 (18.8) | 110 (14.8) | 1.4 | 1.1-1.9 | |
| 96-99 | 42 (5.6) | 29 (3.9) | 1.6 | 1.0-2.7 | |
| 100 | 28 (3.8) | 9 (1.2) | 3.6 | 1.6-7.9 | |
| Anti-annexin V IgM by percentiles | .79 | ||||
| 1-80 | 598 (80.5) | 597 (80.5) | 1.0 | Reference | |
| 81-95 | 115 (15.5) | 109 (14.7) | 1.1 | 0.8-1.4 | |
| 96-99 | 21 (2.8) | 30 (4.0) | 0.7 | 0.4-1.2 | |
| 100 | 9 (1.2) | 7 (1.0) | 1.3 | 0.5-3.5 | |
| Homocysteine, μM | < .001 | ||||
| 3.4-9.8 | 469 (63.1) | 596 (80.2) | 1.0 | Reference | |
| 9.9-12.2 | 151 (20.3) | 109 (14.7) | 1.8 | 1.3-2.3 | |
| 12.3-15.3 | 85 (11.4) | 31 (4.2) | 3.6 | 2.3-5.7 | |
| Greater than 15.3 | 38 (5.1) | 7 (1.0) | 7.3 | 3.0-17.4 |
Biomarker . | Case patients (%) n = 743 . | Control patients (%) n = 743 . | Matched odds ratio . | 95% confidence interval . | P* . |
|---|---|---|---|---|---|
| Antiphosphatidylethanolamine IgG by percentiles | .26 | ||||
| 1-80 | 572 (77.0) | 595 (80.0) | 1.0 | Reference | |
| 81-95 | 134 (18.0) | 111 (14.9) | 1.3 | 1.0-1.7 | |
| 96-99 | 28 (3.8) | 30 (4.0) | 1.0 | 0.6-1.7 | |
| 100 | 9 (1.2) | 7 (1.0) | 1.3 | 0.5-3.6 | |
| Antiphosphatidylethanolamine IgM by percentiles | < .001 | ||||
| 1-80 | 508 (68.4) | 596 (80.2) | 1.0 | Reference | |
| 81-95 | 147 (19.8) | 110 (14.8) | 1.6 | 1.2-2.0 | |
| 96-99 | 37 (5.0) | 28 (3.7) | 1.8 | 1.0-3.0 | |
| 100 | 51 (6.9) | 9 (1.2) | 6.6 | 3.2-13.6 | |
| Anti-β2-glycoprotein 1 IgG by percentiles | .001 | ||||
| 1-80 | 554 (74.6) | 595 (80.0) | 1.0 | Reference | |
| 81-95 | 128 (17.2) | 109 (14.7) | 1.3 | 1.0-1.7 | |
| 96-99 | 40 (5.4) | 31 (4.2) | 1.4 | 0.8-2.2 | |
| 100 | 21 (2.8) | 8 (1.0) | 2.8 | 1.2-6.4 | |
| Anti-β2-glycoprotein 1 IgM by percentiles | .32 | ||||
| 1-80 | 573 (77.1) | 595 (80.1) | 1.0 | Reference | |
| 81-95 | 136 (18.3) | 112 (15.1) | 1.2 | 1.0-1.6 | |
| 96-99 | 24 (3.2) | 29 (3.9) | 0.8 | 0.5-1.5 | |
| 100 | 10 (1.3) | 7 (0.9) | 1.4 | 0.6-3.8 | |
| Anti-annexin V IgG by percentiles | < .001 | ||||
| 1-80 | 533 (71.7) | 595 (80.1) | 1.0 | Reference | |
| 81-95 | 140 (18.8) | 110 (14.8) | 1.4 | 1.1-1.9 | |
| 96-99 | 42 (5.6) | 29 (3.9) | 1.6 | 1.0-2.7 | |
| 100 | 28 (3.8) | 9 (1.2) | 3.6 | 1.6-7.9 | |
| Anti-annexin V IgM by percentiles | .79 | ||||
| 1-80 | 598 (80.5) | 597 (80.5) | 1.0 | Reference | |
| 81-95 | 115 (15.5) | 109 (14.7) | 1.1 | 0.8-1.4 | |
| 96-99 | 21 (2.8) | 30 (4.0) | 0.7 | 0.4-1.2 | |
| 100 | 9 (1.2) | 7 (1.0) | 1.3 | 0.5-3.5 | |
| Homocysteine, μM | < .001 | ||||
| 3.4-9.8 | 469 (63.1) | 596 (80.2) | 1.0 | Reference | |
| 9.9-12.2 | 151 (20.3) | 109 (14.7) | 1.8 | 1.3-2.3 | |
| 12.3-15.3 | 85 (11.4) | 31 (4.2) | 3.6 | 2.3-5.7 | |
| Greater than 15.3 | 38 (5.1) | 7 (1.0) | 7.3 | 3.0-17.4 |
All the variables are divided into 4 categories: percentiles 1-80, 81-95, 96-99, and 100.
P was determined for linear trend.