Analysis of pre-DC subsets in response to in vivo viral infection
. | Blood . | . | Lymph node . | . | ||
|---|---|---|---|---|---|---|
| Subset . | Before infection . | After infection . | Before infection . | After infection . | ||
| CD11c+ pre-DCs* | 11.3 ± 4.1 | 38.0 ± 4.5† | 3.7 ± 1.0 | 2.3 ± 0.8 | ||
| CD123++ pre-DCs | 1.4 ± 0.5 | 0.9 ± 0.1 | 5.6 ± 1.3 | 4.0 ± 2.6 | ||
. | Blood . | . | Lymph node . | . | ||
|---|---|---|---|---|---|---|
| Subset . | Before infection . | After infection . | Before infection . | After infection . | ||
| CD11c+ pre-DCs* | 11.3 ± 4.1 | 38.0 ± 4.5† | 3.7 ± 1.0 | 2.3 ± 0.8 | ||
| CD123++ pre-DCs | 1.4 ± 0.5 | 0.9 ± 0.1 | 5.6 ± 1.3 | 4.0 ± 2.6 | ||
CD11c+ and CD123++ pre-DC subsets were analyzed by 4-color flow in blood and lymphoid tissue 72 hours after intranasal instillation of influenza A virus in 3 naive rhesus monkeys (not Flt3L-mobilized).
Percentage Lin- MHC class 2+ PBMCs or lymph node cells.
P = .02 compared with preinfection value (paired t test).