Table 1. Effect of oral L1... | American Society of Hematology

Table 1.

Effect of oral L1 administration on serum DCI and MDCI and DHR oxidation rates

Patient no.	LPI-DCI	LPI-MDCI	DCI-MDCI
1	0.658	0.655	0.994
2^*	0.104	0.059	0.787
3	0.842	0.803	0.858
4	0.968	0.923	0.897
5	0.646	0.488	0.929
6^*	0.181	−0.097	−0.139
7	0.504	0.766	0.57
8	0.905	0.855	0.983
9	0.825	0.695	0.579
10^*	−0.45	0.239	0.669
Mean (1-10)	0.52	0.54	0.71
SEM	0.14	0.11	0.01
Mean^*	0.76	0.74	0.83
SEM^*	0.06	0.05	0.08

Patient no.	LPI-DCI	LPI-MDCI	DCI-MDCI
1	0.658	0.655	0.994
2^*	0.104	0.059	0.787
3	0.842	0.803	0.858
4	0.968	0.923	0.897
5	0.646	0.488	0.929
6^*	0.181	−0.097	−0.139
7	0.504	0.766	0.57
8	0.905	0.855	0.983
9	0.825	0.695	0.579
10^*	−0.45	0.239	0.669
Mean (1-10)	0.52	0.54	0.71
SEM	0.14	0.11	0.01
Mean^*	0.76	0.74	0.83
SEM^*	0.06	0.05	0.08

The cross correlation coefficients of LPI (measured as 1/DHR oxidation rate) and NTBI parameters (DCI and MDCI) measured in the plasma of 10 L1-treated thalassemia patients were calculated over the entire profile, as depicted in Figure 6 (for 4 of 10 patients). The mean correlation coefficients and their respective SEM values were calculated for all 10 profiles as well for those excluding the 3 profiles that had essentially no detectable levels of MDCI or LPI at the onset of the treatment (patients 2, 6, and 10, labeled with an asterisk).

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