Table 1.

Top 50 of 138 most differentially expressed genes in a comparison of IL-6 response versus IL-6 starvation effect

Accession no.
Gene symbol
Function
Fold difference in geometric means
F test P
Up-regulated     
AF052124 OPN/osteopontin  Bone/ECM   65.61   8.72 × 10−5 
U73379 E2C  Proteolysis   42.32   9.35 × 10−5 
AJ223728 CDC45  Cell cycle   37.12   1.33 × 10−8 
AF053305 BUB1  Cell cycle checkpoint   30.43   1.95 × 10−5 
X62048 WEE1  Cell cycle   29.07   7.55 × 10−7 
D14657 KIAA0101  Unknown   26.32   2.73 × 10−5 
U77949 CDC6  Cell cycle   25.81   1.05 × 10−5 
N58115 EST  Unknown   22.85   .000162  
L25876 CIP2  Signaling   19.5   .000406  
AF067656 Zw10  Wint signaling   18.17   1.38 × 10−6 
U74612 FKHL16  Transcription factor   17.4   1.99 × 10−5 
AF025441 OIP5  Unknown   17.34   .000198  
U37426 HKSP  Cell division   17.28   1.22 × 10−5 
D80008 KIAA0186  Unknown   15.97   1.56 × 10−5 
Y13115 SAK  Signaling   15.84   .000811  
U63743 KNSL6  Cell division   15.8   .000119  
D14678 MHCB  Cell division   15.52   .000154  
U14518 CENP-A  Cell division   15.45   1.04 × 10−7 
M25753 Cyclin B  Cell cycle   14.22   3.3 × 10−7 
U05340 p55CDC  Cell cycle   14.22   4.58 × 10−5 
Z15005 CENP-E  Cell division   13.71   6.88 × 10−7 
AF053306 MAD3L  Checkpoint   12.93   7.33 × 10−7 
AA203476 PTTG1  Sister chromatid separation/cell division   12.84   1.33 × 10−6 
X13293 B-myb  Transcription factor   12.83   2.3 × 10−6 
AF016582 Chk1  Checkpoint   12.67   .00089  
AJ000186 MAD2  Mitotic checkpoint   12.3   4.18 × 10−5 
M86699 TTK  Signaling   11.87   .000384  
AB017430 KNSL4  Cell division/cytoskeleton   11.84   3.35 × 10−7 
L33594 ATX  Metabolism   11.76   .00019  
M36067 LIG1  Metabolism   11.73   2.97 × 10−8 
AI375913 TOP2A  DNA replication   11.56   .000182  
AI391564 PTP4A3  Signaling   11.24   2.53 × 10−5 
J00140 DHFR  Metabolism   11.14   .00078  
M80397 POLD1  DNA replication   10.81   9.58 × 10−8 
M15205 TK1  Metabolism   10.78   5.23 × 10−9 
AL080146 CCNB2  Cell cycle   10.72   3.19 × 10−5 
X59618 RRM2  Metabolism   10.44   6.47 × 10−5 
Down-regulated     
M24594 IFI56  Growth suppression   21.22   8.85 × 10−5 
U81523 EBAF  Signaling   6.90   1.71 × 10−6 
AJ130718 SCLA9  Solute carrier   6.83   .000117  
AF093265 HOMER3  Metabolism   6.18   1.11 × 10−5 
AB016811 ARL7  Metabolism   5.59   .000684  
M14660 IFI54  Growth suppression   5.47   8.47 × 10−5 
D64137 KIP2  Growth suppression   4.43   .000208  
AB020689 KIAA0882  Unknown   4.17   .00036  
U12255 FCGRT  Immunity   3.85   .000549  
M14949 R-RAS  Oncogene/signaling   3.77   .000958  
M32011 CGD  Metabolism   3.67   3.21 × 10−6 
M80899 AHNAK  Cell interaction/desmosome   3.53   .000138  
M15059
 		CD23
 		 Immunity
 		 3.17
 		 .000399
 
Accession no.
Gene symbol
Function
Fold difference in geometric means
F test P
Up-regulated     
AF052124 OPN/osteopontin  Bone/ECM   65.61   8.72 × 10−5 
U73379 E2C  Proteolysis   42.32   9.35 × 10−5 
AJ223728 CDC45  Cell cycle   37.12   1.33 × 10−8 
AF053305 BUB1  Cell cycle checkpoint   30.43   1.95 × 10−5 
X62048 WEE1  Cell cycle   29.07   7.55 × 10−7 
D14657 KIAA0101  Unknown   26.32   2.73 × 10−5 
U77949 CDC6  Cell cycle   25.81   1.05 × 10−5 
N58115 EST  Unknown   22.85   .000162  
L25876 CIP2  Signaling   19.5   .000406  
AF067656 Zw10  Wint signaling   18.17   1.38 × 10−6 
U74612 FKHL16  Transcription factor   17.4   1.99 × 10−5 
AF025441 OIP5  Unknown   17.34   .000198  
U37426 HKSP  Cell division   17.28   1.22 × 10−5 
D80008 KIAA0186  Unknown   15.97   1.56 × 10−5 
Y13115 SAK  Signaling   15.84   .000811  
U63743 KNSL6  Cell division   15.8   .000119  
D14678 MHCB  Cell division   15.52   .000154  
U14518 CENP-A  Cell division   15.45   1.04 × 10−7 
M25753 Cyclin B  Cell cycle   14.22   3.3 × 10−7 
U05340 p55CDC  Cell cycle   14.22   4.58 × 10−5 
Z15005 CENP-E  Cell division   13.71   6.88 × 10−7 
AF053306 MAD3L  Checkpoint   12.93   7.33 × 10−7 
AA203476 PTTG1  Sister chromatid separation/cell division   12.84   1.33 × 10−6 
X13293 B-myb  Transcription factor   12.83   2.3 × 10−6 
AF016582 Chk1  Checkpoint   12.67   .00089  
AJ000186 MAD2  Mitotic checkpoint   12.3   4.18 × 10−5 
M86699 TTK  Signaling   11.87   .000384  
AB017430 KNSL4  Cell division/cytoskeleton   11.84   3.35 × 10−7 
L33594 ATX  Metabolism   11.76   .00019  
M36067 LIG1  Metabolism   11.73   2.97 × 10−8 
AI375913 TOP2A  DNA replication   11.56   .000182  
AI391564 PTP4A3  Signaling   11.24   2.53 × 10−5 
J00140 DHFR  Metabolism   11.14   .00078  
M80397 POLD1  DNA replication   10.81   9.58 × 10−8 
M15205 TK1  Metabolism   10.78   5.23 × 10−9 
AL080146 CCNB2  Cell cycle   10.72   3.19 × 10−5 
X59618 RRM2  Metabolism   10.44   6.47 × 10−5 
Down-regulated     
M24594 IFI56  Growth suppression   21.22   8.85 × 10−5 
U81523 EBAF  Signaling   6.90   1.71 × 10−6 
AJ130718 SCLA9  Solute carrier   6.83   .000117  
AF093265 HOMER3  Metabolism   6.18   1.11 × 10−5 
AB016811 ARL7  Metabolism   5.59   .000684  
M14660 IFI54  Growth suppression   5.47   8.47 × 10−5 
D64137 KIP2  Growth suppression   4.43   .000208  
AB020689 KIAA0882  Unknown   4.17   .00036  
U12255 FCGRT  Immunity   3.85   .000549  
M14949 R-RAS  Oncogene/signaling   3.77   .000958  
M32011 CGD  Metabolism   3.67   3.21 × 10−6 
M80899 AHNAK  Cell interaction/desmosome   3.53   .000138  
M15059
 		CD23
 		 Immunity
 		 3.17
 		 .000399
 
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