Location and type of tumors observed in mice from the FanccTrp53 intercross
Genotype (no. animals/group) . | Type of tumors observed . | No. of each tumor type observed . | % of each tumor type observed . |
|---|---|---|---|
| Fancc+/+Trp53+/+ (20) | No tumors | — | — |
| Fancc−/−Trp53+/+ (20) | No tumors | — | — |
| Fancc+/+Trp53+/− (17) | Osteosarcoma | 4 | 36 |
| Fancc+/+Trp53+/− | Sarcoma | 2 | 18 |
| Fancc+/+Trp53+/− | Lymphoma | 3 | 27 |
| Fancc+/+Trp53+/− | Hemangiosarcoma | 2 | 18 |
| Fancc+/+Trp53+/− | Total | 11 | 100 |
| Fancc−/−Trp53+/− (22) | Osteosarcoma | 4 | 31 |
| Fancc−/−Trp53+/− | Fibrosarcoma (muscle) | 1 | 8 |
| Fancc−/−Trp53+/− | Dermal spindle-cell tumor (neck) | 1 | 8 |
| Fancc−/−Trp53+/− | Lymphoma | 5 | 38 |
| Fancc−/−Trp53+/− | Myeloid malignancy (histiocytic) | 1 | 8 |
| Fancc−/−Trp53+/− | Ovarian tumor | 1 | 8 |
| Fancc−/−Trp53+/− | Total | 13 | 100 |
| Fancc+/+Trp53−/− (21) | Lymphoma (primarily thymic) | 11 | 73 |
| Fancc+/+Trp53−/− | Other anaplastic sarcoma | 4 | 27 |
| Fancc+/+Trp53−/− | Total | 15 | 100 |
| Fancc−/−Trp53−/− (7) | Adenocarcinoma (prostate) | 1 | 25 |
| Fancc−/−Trp53−/− | Lymphoma | 1 | 25 |
| Fancc−/−Trp53−/− | Anaplastic sarcoma (cardiac) | 1 | 25 |
| Fancc−/−Trp53−/− | Medulloblastoma | 1 | 25 |
| Fancc−/−Trp53−/− | Total | 4 | 100 |
Genotype (no. animals/group) . | Type of tumors observed . | No. of each tumor type observed . | % of each tumor type observed . |
|---|---|---|---|
| Fancc+/+Trp53+/+ (20) | No tumors | — | — |
| Fancc−/−Trp53+/+ (20) | No tumors | — | — |
| Fancc+/+Trp53+/− (17) | Osteosarcoma | 4 | 36 |
| Fancc+/+Trp53+/− | Sarcoma | 2 | 18 |
| Fancc+/+Trp53+/− | Lymphoma | 3 | 27 |
| Fancc+/+Trp53+/− | Hemangiosarcoma | 2 | 18 |
| Fancc+/+Trp53+/− | Total | 11 | 100 |
| Fancc−/−Trp53+/− (22) | Osteosarcoma | 4 | 31 |
| Fancc−/−Trp53+/− | Fibrosarcoma (muscle) | 1 | 8 |
| Fancc−/−Trp53+/− | Dermal spindle-cell tumor (neck) | 1 | 8 |
| Fancc−/−Trp53+/− | Lymphoma | 5 | 38 |
| Fancc−/−Trp53+/− | Myeloid malignancy (histiocytic) | 1 | 8 |
| Fancc−/−Trp53+/− | Ovarian tumor | 1 | 8 |
| Fancc−/−Trp53+/− | Total | 13 | 100 |
| Fancc+/+Trp53−/− (21) | Lymphoma (primarily thymic) | 11 | 73 |
| Fancc+/+Trp53−/− | Other anaplastic sarcoma | 4 | 27 |
| Fancc+/+Trp53−/− | Total | 15 | 100 |
| Fancc−/−Trp53−/− (7) | Adenocarcinoma (prostate) | 1 | 25 |
| Fancc−/−Trp53−/− | Lymphoma | 1 | 25 |
| Fancc−/−Trp53−/− | Anaplastic sarcoma (cardiac) | 1 | 25 |
| Fancc−/−Trp53−/− | Medulloblastoma | 1 | 25 |
| Fancc−/−Trp53−/− | Total | 4 | 100 |
Fifty-seven of the 107 mice shown in Figure 3 died during the course of the study, of which 44 were subjected to autopsy. Thirty-eight animals developed a total of 43 tumors, which were evaluated in detail by histologic examination. In some tumors, immunohistochemical analysis was also used to identify specific cell lineages. — indicates not applicable.