bFGF expression in MM patients
. | . | . | . | . | . | . | bFGF protein . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients . | Age, y . | Type . | PC, % . | Stage . | Osteolysis . | bFGF mRNA RT-PCR . | ELISA . | Western blot . | Immunostaining . | ||
| 1 | 61 | Aλ | 90 | IIIa | + | + | + | + | ++ | ||
| 2 | 68 | Gκ | 70 | IIIa | + | - | - | - | - | ||
| 3 | 66 | Gκ | 30 | IIIa | + | - | - | - | - | ||
| 4 | 61 | Gκ | 35 | IIIa | + | - | - | - | - | ||
| 5 | 88 | Gλ | 20 | IIIa | + | - | - | - | - | ||
| 6 | 61 | Gλ | 70 | IIIa | + | + | + | + | + | ||
| 7 | 71 | Gκ | 20 | Ia | +<3 | - | - | - | - | ||
| 8 | 39 | Gκ | 30 | IIIa | + | + | - | - | - | ||
| 9 | 54 | G | 35 | IIIa | + | - | - | - | ND | ||
| 10 | 62 | G | 90 | IIa | +<3 | - | - | - | ND | ||
| 11 | 60 | Aκ | 65 | IIa | + | + | + | ND | - | ||
| 12 | 65 | Gκ | 40 | IIIa | + | - | - | - | - | ||
| 13 | 85 | κ | 50 | IIIb | + | + | ND | ND | ND | ||
| 14 | 73 | Aκ | 45 | Ia | +<3 | + | ND | +/- | ND | ||
| 15 | 71 | Aκ | 30 | IIIa | + | - | - | - | ND | ||
| 16 | 82 | Gλ | 50 | IIa | - | - | - | - | ND | ||
| 17 | 59 | Gκ | 20 | IIIa | + | - | - | - | ND | ||
| 18 | 68 | λ | 75 | IIb | - | - | - | - | - | ||
| 19 | 78 | Gκ | 80 | IIIa | + | + | ND | ND | ND | ||
| 20 | 48 | A | 60 | IIIa | + | + | + | + | + | ||
| 21 | 76 | Aκ | 25 | Ia | - | + | ND | ND | ND | ||
| 22 | 61 | Aκ | 95 | IIb | - | + | + | ND | - | ||
| 23 | 64 | Gκ | 60 | IIIb | + | - | - | - | - | ||
| 24 | 50 | Gκ | 15 | Ia | - | - | - | - | - | ||
| 25 | 73 | Aλ | 70 | Ia | + | - | - | - | - | ||
| 26 | 41 | Gλ | 20 | IIIa | + | - | - | - | ND | ||
| 27 | 77 | Gκ | 12 | Ia | - | -/+ | ND | + | ND | ||
| 28 | 52 | Gκ | 15 | Ia | - | -/+ | ND | + | - | ||
| 29 | 66 | Aλ | 45 | IIIa | + | - | - | - | - | ||
| 30 | 72 | Aλ | 28 | IIIa | + | + | + | + | ND | ||
| 31 | 52 | κ | 15 | IIIa | + | -/+ | + | + | ND | ||
| 32 | 81 | κ | 20 | Ib | - | - | - | - | - | ||
| 33 | 73 | Gκ | 15 | IIa | - | - | - | - | - | ||
| 34 | 35 | Gλ | 80 | IIIa | + | - | - | - | - | ||
| 35 | 66 | Gλ | 35 | IIIb | + | -/+ | ND | + | ND | ||
. | . | . | . | . | . | . | bFGF protein . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients . | Age, y . | Type . | PC, % . | Stage . | Osteolysis . | bFGF mRNA RT-PCR . | ELISA . | Western blot . | Immunostaining . | ||
| 1 | 61 | Aλ | 90 | IIIa | + | + | + | + | ++ | ||
| 2 | 68 | Gκ | 70 | IIIa | + | - | - | - | - | ||
| 3 | 66 | Gκ | 30 | IIIa | + | - | - | - | - | ||
| 4 | 61 | Gκ | 35 | IIIa | + | - | - | - | - | ||
| 5 | 88 | Gλ | 20 | IIIa | + | - | - | - | - | ||
| 6 | 61 | Gλ | 70 | IIIa | + | + | + | + | + | ||
| 7 | 71 | Gκ | 20 | Ia | +<3 | - | - | - | - | ||
| 8 | 39 | Gκ | 30 | IIIa | + | + | - | - | - | ||
| 9 | 54 | G | 35 | IIIa | + | - | - | - | ND | ||
| 10 | 62 | G | 90 | IIa | +<3 | - | - | - | ND | ||
| 11 | 60 | Aκ | 65 | IIa | + | + | + | ND | - | ||
| 12 | 65 | Gκ | 40 | IIIa | + | - | - | - | - | ||
| 13 | 85 | κ | 50 | IIIb | + | + | ND | ND | ND | ||
| 14 | 73 | Aκ | 45 | Ia | +<3 | + | ND | +/- | ND | ||
| 15 | 71 | Aκ | 30 | IIIa | + | - | - | - | ND | ||
| 16 | 82 | Gλ | 50 | IIa | - | - | - | - | ND | ||
| 17 | 59 | Gκ | 20 | IIIa | + | - | - | - | ND | ||
| 18 | 68 | λ | 75 | IIb | - | - | - | - | - | ||
| 19 | 78 | Gκ | 80 | IIIa | + | + | ND | ND | ND | ||
| 20 | 48 | A | 60 | IIIa | + | + | + | + | + | ||
| 21 | 76 | Aκ | 25 | Ia | - | + | ND | ND | ND | ||
| 22 | 61 | Aκ | 95 | IIb | - | + | + | ND | - | ||
| 23 | 64 | Gκ | 60 | IIIb | + | - | - | - | - | ||
| 24 | 50 | Gκ | 15 | Ia | - | - | - | - | - | ||
| 25 | 73 | Aλ | 70 | Ia | + | - | - | - | - | ||
| 26 | 41 | Gλ | 20 | IIIa | + | - | - | - | ND | ||
| 27 | 77 | Gκ | 12 | Ia | - | -/+ | ND | + | ND | ||
| 28 | 52 | Gκ | 15 | Ia | - | -/+ | ND | + | - | ||
| 29 | 66 | Aλ | 45 | IIIa | + | - | - | - | - | ||
| 30 | 72 | Aλ | 28 | IIIa | + | + | + | + | ND | ||
| 31 | 52 | κ | 15 | IIIa | + | -/+ | + | + | ND | ||
| 32 | 81 | κ | 20 | Ib | - | - | - | - | - | ||
| 33 | 73 | Gκ | 15 | IIa | - | - | - | - | - | ||
| 34 | 35 | Gλ | 80 | IIIa | + | - | - | - | - | ||
| 35 | 66 | Gλ | 35 | IIIb | + | -/+ | ND | + | ND | ||
PC indicates plasmacytosis; +, positive; -, negative; +/-, low expression; and ND, not determined.