Tyrosine kinase sensitivity to CR4 inhibition
Kinase . | IC50, μM . |
|---|---|
| Btk | > 5 |
| Bcr-Abl | 0.5-0.7 |
| Jak2 | 0.1-0.6 |
| Lck | > 5 |
| Lyn | > 50 |
| Src | > 25 |
| Syk | > 5 |
| Zap-70 | > 5 |
Kinase . | IC50, μM . |
|---|---|
| Btk | > 5 |
| Bcr-Abl | 0.5-0.7 |
| Jak2 | 0.1-0.6 |
| Lck | > 5 |
| Lyn | > 50 |
| Src | > 25 |
| Syk | > 5 |
| Zap-70 | > 5 |
Results represent multiple independent experiments with each protein tyrosine kinase. In particular, Jak-2 and Bcr-Abl kinase assays were performed repeatedly (>6 each) on enzymes extracted from various cell lines including Ph+ and Ph− ALL and AML. To reflect most accurately the large number of experiments, the range of IC50 for Jak-2 and Bcr-Abl is given.