B hermsii infection results in thrombocytopenia and prolonged bleeding time in mice
Mouse no. . | Platelets/μL, × 103 . | Bacteria/μL, × 103 . | Bleeding time, s . |
|---|---|---|---|
| Mock-infected | |||
| 1 | 810 | NA | 58 |
| 2 | 900 | NA | 56 |
| 3 | 1150 | NA | 52 |
| 4 | 1100 | NA | 72 |
| 5 | 1130 | NA | 60 |
| B hermsii—infected | |||
| 6 | 70 | 40.0 | > 600 |
| 7 | 60 | 26.6 | > 600 |
| 8 | 120 | 13.3 | 316 |
| 9 | 210 | 7.0 | 292 |
| 10 | 50 | 13.3 | > 600 |
Mouse no. . | Platelets/μL, × 103 . | Bacteria/μL, × 103 . | Bleeding time, s . |
|---|---|---|---|
| Mock-infected | |||
| 1 | 810 | NA | 58 |
| 2 | 900 | NA | 56 |
| 3 | 1150 | NA | 52 |
| 4 | 1100 | NA | 72 |
| 5 | 1130 | NA | 60 |
| B hermsii—infected | |||
| 6 | 70 | 40.0 | > 600 |
| 7 | 60 | 26.6 | > 600 |
| 8 | 120 | 13.3 | 316 |
| 9 | 210 | 7.0 | 292 |
| 10 | 50 | 13.3 | > 600 |
Platelet and spirochete counts in blood were determined by flow cytometry and by visual counting, respectively. Bleeding times were measured on mock- or 2-day postinfected mice, as described in “Materials and methods.” NA indicates not applicable.