Table 6. Examples of genes coregulated... | American Society of Hematology

Table 6.

Examples of genes coregulated by Epo, Dex, and SCF in expansion of erythroid progenitors (from the indicated profile groups shown inTable 5 )

Profile group, accession no.	Gene description	Epo	SCF	Dex	ES	ESD	ESZK	ESD/ESZK
3A ESD/ESZK up, Dex up
*AI853706*	*Rho guanine nucleotide exchange factor (GEF)3*	*1.10*	*0.91*	*2.25*	*1.30*	*3.49*	*1.24*	*2.80*
AI847541	zinc finger protein 61	0.69	0.77	2.15	0.68	1.07	0.58	1.85
*AI845829*	*Asialoglycoprotein receptor 1*	*1.26*	*1.44*	*2.10*	*1.40*	*2.02*	*1.23*	*1.65*
AI415662	Mm.23097	1.02	0.95	2.09	1.14	2.07	0.91	2.28
*AI840878*	*RIKEN cDNA 2300002F06 gene*	*1.04*	*1.26*	*2.07*	*1.16*	*2.50*	*1.08*	*2.32*
AI840515	EST	0.60	0.76	2.06	0.63	1.14	0.72	1.59
*AI844317*	*Mm.41137*	*1.23*	*0.64*	*1.97*	*1.01*	*1.45*	*0.82*	*1.76*
AI854349	Serum/glucocorticoid regulated kinase	0.84	0.87	1.95	0.63	2.56	0.79	3.24
*AI465375*	*RIKEN cDNA 2510025F08 gene*	*0.99*	*0.89*	*1.88*	*0.89*	*1.27*	*0.78*	*1.62*
AI841954	Mm.38924	0.90	0.68	1.86	0.76	1.18	0.58	2.04
*AI837598*	*RIKEN cDNA 1300007C21 gene*	*0.91*	*0.62*	*1.82*	*0.66*	*0.96*	*0.50*	*1.91*
AI846411	Mm.218636	1.40	0.79	1.73	1.50	2.45	1.11	2.20
*AI447893*	*Mm.30874*	*0.98*	*1.12*	*1.61*	*0.95*	*2.03*	*1.10*	*1.85*
AI846077	Sec7 and coiled/coil domains 3	0.78	0.92	1.58	0.60	0.97	0.52	1.85
*AI850091*	*CD59a antigen*	*1.36*	*0.82*	*1.57*	*1.04*	*1.75*	*1.10*	*1.58*
AI326787	lipoprotein lipase	0.98	1.12	1.52	1.08	1.68	0.94	1.78
*AA199458*	*IMAGE:638536*	*0.96*	*0.75*	*1.65*	*0.71*	*0.82*	*0.51*	*1.63*
D87747	CXCR-4	0.69	0.86	1.93	0.46	0.82	0.44	1.89
3B ESD/ESZK down, Dex down
*AI853422*	*EST cluster Mm.259384*	*1.39*	*0.95*	*0.64*	*1.65*	*1.27*	*2.05*	*0.62*
AI413887	EST cluster Mm.22863	0.71	1.10	0.67	0.62	0.60	0.99	0.61
5A1 Epo up, Dex up
*AI528522*	*Protein kinase C, theta*	*2.52*	*0.62*	*1.11*	*1.91*	*2.92*	*1.53*	*1.91*
AI385650	Beta-galactosidase alpha-2,3-sialytransferase	2.38-2.63	1.22-1.07	1.32-0.99	3.05-3.07	3.82-3.86	1.88-1.90	2.03-2.03
*AI323712*	*ATPase, beta 56/58 kDa, isoform 2*	*1.75*	*0.92*	*1.00*	*2.06*	*2.55*	*1.21*	*2.11*
AI838311	Matrix metalloproteinase 2	2.22-2.14	1.18-1.08	0.96-0.96	2.07-2.43	3.70-7.52	1.46-1.80	2.54-4.19
*AI834916*	*EST, cluster Mm.24036*	*2.35*	*1.04*	*1.38*	*1.98*	*3.24*	*1.89*	*1.72*
5B1 Epo up, Dex down
*AI850575*	*Phospholipase C, epsilon 2*	*1.93-2.16*	*1.11-0.99*	*1.27-1.47*	*2.31-2.27*	*1.66-1.61*	*2.18-2.53*	*0.76-0.64*
AI385595	Cytokine inducible SH2-containing protein	4.49	1.15	1.03	2.87	2.15	4.44	0.48
*AI854137*	*EST AA408729*	*2.19*	*1.39*	*0.96*	*2.87*	*1.85*	*3.04*	*0.61*
5A2 Epo down, Dex up
*AI843911*	*Glucocorticoid-induced leucine zipper*	*0.46-0.53*	*0.72-0.76*	*2.93-2.46*	*0.42-0.52*	*1.06-1.08*	*0.82-0.53*	*1.72-0.77*
AI450157	Chloride intracellular channel 1	0.52	0.74	0.88	0.49	0.99	0.63	1.57
6A1 SCF up, Dex up
*AI847904*	*SEC22 vesicle trafficking proteinlike 1*	*1.38*	*1.85*	*1.09*	*0.97*	*2.02*	*0.78*	*2.60*
AI836926	Melanoma X-actin	1.73	2.00	1.19	1.80	2.15	1.12	1.92
*AI893440*	*RAB4A, member RAS oncogene family*	*1.04*	*1.81*	*0.98*	*0.67*	*0.93*	*0.47*	*1.98*
6B1 SCF up, Dex down
*AI836530*	*RIKEN cDNA 3110038L01 gene*	*1.48*	*1.99*	*0.94*	*2.17*	*1.38*	*2.21*	*0.62*
6A2 SCF down, Dex up
*AI851500*	*RIKEN cDNA 1110046J11 gene*	*0.70*	*0.52*	*1.25*	*0.44*	*0.53*	*0.33*	*1.58*
AI849362	EST, clusterMm.41089	0.91	0.59	1.02	0.40	0.75	0.41	1.82
*AI848411*	*B-cell translocation gene 1*	*0.71-0.88*	*0.48-0.50*	*1.68-1.45*	*0.45-0.60*	*1.07-1.07*	*0.41-0.57*	*2.63-1.86*
AI846731	RIKEN cDNA 2700017106	1.08	0.41	1.83	0.90	1.76	0.75	2.33
7A1 ES up, Dex up
*A1844751*	*Translation releasing factor eRF-1*	*1.91*	*2.06*	*0.93*	*2.92*	*1.83*	*0.94*	*1.94*
AI850110	WD repeat domain 1	1.83	2.51	1.04	2.35	2.08	0.94	2.20
*AI323629*	*Low-density lipoprotein receptor*	*1.82*	*2.56*	*1.00*	*2.42*	*2.35*	*1.44*	*1.63*
7B1 ES up, Dex down
*AI323806*	*Cyclin-dependent kinase inhibitor 1A(P21)*	*1.91*	*1.12*	*0.76*	*3.13*	*2.00*	*4.22*	*0.47*
AI840156	RIKEN cDNA 2310076D10 gene	1.78	2.54	1.10	2.87	2.00	3.19	0.63
7A3 ES down, Dex up
*AI428195*	*RIKEN cDNA 2410024N18 gene*	*0.55*	*0.44*	*1.54*	*0.27*	*0.50*	*0.32*	*1.56*
AB022209	Ribonucleoprotein F	0.61-0.65	0.51-0.48	1.75-1.60	0.49-0.52	0.56-0.63	0.45-0.52	1.24-1.21
*AI846040*	*RIKEN cDNA 1500004A08 gene*	*0.56*	*0.39*	*1.43*	*0.25*	*0.70*	*0.37*	*1.90*
D87747	CXCR-4	0.69	0.86	1.93	0.46	0.82	0.44	1.89

Profile group, accession no.	Gene description	Epo	SCF	Dex	ES	ESD	ESZK	ESD/ESZK
3A ESD/ESZK up, Dex up
*AI853706*	*Rho guanine nucleotide exchange factor (GEF)3*	*1.10*	*0.91*	*2.25*	*1.30*	*3.49*	*1.24*	*2.80*
AI847541	zinc finger protein 61	0.69	0.77	2.15	0.68	1.07	0.58	1.85
*AI845829*	*Asialoglycoprotein receptor 1*	*1.26*	*1.44*	*2.10*	*1.40*	*2.02*	*1.23*	*1.65*
AI415662	Mm.23097	1.02	0.95	2.09	1.14	2.07	0.91	2.28
*AI840878*	*RIKEN cDNA 2300002F06 gene*	*1.04*	*1.26*	*2.07*	*1.16*	*2.50*	*1.08*	*2.32*
AI840515	EST	0.60	0.76	2.06	0.63	1.14	0.72	1.59
*AI844317*	*Mm.41137*	*1.23*	*0.64*	*1.97*	*1.01*	*1.45*	*0.82*	*1.76*
AI854349	Serum/glucocorticoid regulated kinase	0.84	0.87	1.95	0.63	2.56	0.79	3.24
*AI465375*	*RIKEN cDNA 2510025F08 gene*	*0.99*	*0.89*	*1.88*	*0.89*	*1.27*	*0.78*	*1.62*
AI841954	Mm.38924	0.90	0.68	1.86	0.76	1.18	0.58	2.04
*AI837598*	*RIKEN cDNA 1300007C21 gene*	*0.91*	*0.62*	*1.82*	*0.66*	*0.96*	*0.50*	*1.91*
AI846411	Mm.218636	1.40	0.79	1.73	1.50	2.45	1.11	2.20
*AI447893*	*Mm.30874*	*0.98*	*1.12*	*1.61*	*0.95*	*2.03*	*1.10*	*1.85*
AI846077	Sec7 and coiled/coil domains 3	0.78	0.92	1.58	0.60	0.97	0.52	1.85
*AI850091*	*CD59a antigen*	*1.36*	*0.82*	*1.57*	*1.04*	*1.75*	*1.10*	*1.58*
AI326787	lipoprotein lipase	0.98	1.12	1.52	1.08	1.68	0.94	1.78
*AA199458*	*IMAGE:638536*	*0.96*	*0.75*	*1.65*	*0.71*	*0.82*	*0.51*	*1.63*
D87747	CXCR-4	0.69	0.86	1.93	0.46	0.82	0.44	1.89
3B ESD/ESZK down, Dex down
*AI853422*	*EST cluster Mm.259384*	*1.39*	*0.95*	*0.64*	*1.65*	*1.27*	*2.05*	*0.62*
AI413887	EST cluster Mm.22863	0.71	1.10	0.67	0.62	0.60	0.99	0.61
5A1 Epo up, Dex up
*AI528522*	*Protein kinase C, theta*	*2.52*	*0.62*	*1.11*	*1.91*	*2.92*	*1.53*	*1.91*
AI385650	Beta-galactosidase alpha-2,3-sialytransferase	2.38-2.63	1.22-1.07	1.32-0.99	3.05-3.07	3.82-3.86	1.88-1.90	2.03-2.03
*AI323712*	*ATPase, beta 56/58 kDa, isoform 2*	*1.75*	*0.92*	*1.00*	*2.06*	*2.55*	*1.21*	*2.11*
AI838311	Matrix metalloproteinase 2	2.22-2.14	1.18-1.08	0.96-0.96	2.07-2.43	3.70-7.52	1.46-1.80	2.54-4.19
*AI834916*	*EST, cluster Mm.24036*	*2.35*	*1.04*	*1.38*	*1.98*	*3.24*	*1.89*	*1.72*
5B1 Epo up, Dex down
*AI850575*	*Phospholipase C, epsilon 2*	*1.93-2.16*	*1.11-0.99*	*1.27-1.47*	*2.31-2.27*	*1.66-1.61*	*2.18-2.53*	*0.76-0.64*
AI385595	Cytokine inducible SH2-containing protein	4.49	1.15	1.03	2.87	2.15	4.44	0.48
*AI854137*	*EST AA408729*	*2.19*	*1.39*	*0.96*	*2.87*	*1.85*	*3.04*	*0.61*
5A2 Epo down, Dex up
*AI843911*	*Glucocorticoid-induced leucine zipper*	*0.46-0.53*	*0.72-0.76*	*2.93-2.46*	*0.42-0.52*	*1.06-1.08*	*0.82-0.53*	*1.72-0.77*
AI450157	Chloride intracellular channel 1	0.52	0.74	0.88	0.49	0.99	0.63	1.57
6A1 SCF up, Dex up
*AI847904*	*SEC22 vesicle trafficking proteinlike 1*	*1.38*	*1.85*	*1.09*	*0.97*	*2.02*	*0.78*	*2.60*
AI836926	Melanoma X-actin	1.73	2.00	1.19	1.80	2.15	1.12	1.92
*AI893440*	*RAB4A, member RAS oncogene family*	*1.04*	*1.81*	*0.98*	*0.67*	*0.93*	*0.47*	*1.98*
6B1 SCF up, Dex down
*AI836530*	*RIKEN cDNA 3110038L01 gene*	*1.48*	*1.99*	*0.94*	*2.17*	*1.38*	*2.21*	*0.62*
6A2 SCF down, Dex up
*AI851500*	*RIKEN cDNA 1110046J11 gene*	*0.70*	*0.52*	*1.25*	*0.44*	*0.53*	*0.33*	*1.58*
AI849362	EST, clusterMm.41089	0.91	0.59	1.02	0.40	0.75	0.41	1.82
*AI848411*	*B-cell translocation gene 1*	*0.71-0.88*	*0.48-0.50*	*1.68-1.45*	*0.45-0.60*	*1.07-1.07*	*0.41-0.57*	*2.63-1.86*
AI846731	RIKEN cDNA 2700017106	1.08	0.41	1.83	0.90	1.76	0.75	2.33
7A1 ES up, Dex up
*A1844751*	*Translation releasing factor eRF-1*	*1.91*	*2.06*	*0.93*	*2.92*	*1.83*	*0.94*	*1.94*
AI850110	WD repeat domain 1	1.83	2.51	1.04	2.35	2.08	0.94	2.20
*AI323629*	*Low-density lipoprotein receptor*	*1.82*	*2.56*	*1.00*	*2.42*	*2.35*	*1.44*	*1.63*
7B1 ES up, Dex down
*AI323806*	*Cyclin-dependent kinase inhibitor 1A(P21)*	*1.91*	*1.12*	*0.76*	*3.13*	*2.00*	*4.22*	*0.47*
AI840156	RIKEN cDNA 2310076D10 gene	1.78	2.54	1.10	2.87	2.00	3.19	0.63
7A3 ES down, Dex up
*AI428195*	*RIKEN cDNA 2410024N18 gene*	*0.55*	*0.44*	*1.54*	*0.27*	*0.50*	*0.32*	*1.56*
AB022209	Ribonucleoprotein F	0.61-0.65	0.51-0.48	1.75-1.60	0.49-0.52	0.56-0.63	0.45-0.52	1.24-1.21
*AI846040*	*RIKEN cDNA 1500004A08 gene*	*0.56*	*0.39*	*1.43*	*0.25*	*0.70*	*0.37*	*1.90*
D87747	CXCR-4	0.69	0.86	1.93	0.46	0.82	0.44	1.89

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