Table 4.

Binding of kinectin-derived peptides and controls to HLA-A*0201

Name
Sequence
Protein
Position
Score*
Fluorescence index†
794S   SLVEELKKV   Kinectin   aa 794   656   2.8  
645F   FLLKAEVQKL   Kinectin   aa 645   836   1.5  
600V   VLAEELHKV   Kinectin   aa 600   1115   0.6  
553Q   ALMESEQKV   Kinectin   aa 552   1055   0.3  
F271   FLWGPRALV (positive control)   MAGE-3   aa 271   2655   2.0  
A98-Id‡
 		 AHTKDGFNF (negative control)
 		 Idiotype
 		 aa 98
 		 0
 		 0.1
 
Name
Sequence
Protein
Position
Score*
Fluorescence index†
794S   SLVEELKKV   Kinectin   aa 794   656   2.8  
645F   FLLKAEVQKL   Kinectin   aa 645   836   1.5  
600V   VLAEELHKV   Kinectin   aa 600   1115   0.6  
553Q   ALMESEQKV   Kinectin   aa 552   1055   0.3  
F271   FLWGPRALV (positive control)   MAGE-3   aa 271   2655   2.0  
A98-Id‡
 		 AHTKDGFNF (negative control)
 		 Idiotype
 		 aa 98
 		 0
 		 0.1
 
*

Calculated score in arbitrary units.

†

(Mean fluorescence with peptide-mean fluorescence without peptide)/(mean fluorescence without peptide).

‡

Peptide sequence obtained from the idiotypic sequence of a patient with plasma cell leukemia and predicted to bind to HLA-B38.

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