Table 1.

Initial patient data




No.
Number of patients   103  
Median age, y (range)   6.8 (0.2-17.1)  
Sex, male/female   54/49  
Median WBC, 109/L (range)   48 (2-688)  
Median percentage of leukemic cells, WBC (range)   83 (1-100)* 
BCR/ABL, yes/no/NA   1/44/58  
MLL/AF4, yes/no/NA   0/45/58  
TEL/AML 1, yes/no/NA   4/41/58  
Liver, more than 3 cm below costal margin, yes/no/NA   52/48/3  
Spleen, more than 3 cm below costal margin, yes/no/NA   51/49/3  
Response to prednisone, good poor NA   44/9/50  
Immunophenotype  
Precursor B lineage, male/female   71 (34/37)  
T lineage, male/female
 
32 (20/12)
 



No.
Number of patients   103  
Median age, y (range)   6.8 (0.2-17.1)  
Sex, male/female   54/49  
Median WBC, 109/L (range)   48 (2-688)  
Median percentage of leukemic cells, WBC (range)   83 (1-100)* 
BCR/ABL, yes/no/NA   1/44/58  
MLL/AF4, yes/no/NA   0/45/58  
TEL/AML 1, yes/no/NA   4/41/58  
Liver, more than 3 cm below costal margin, yes/no/NA   52/48/3  
Spleen, more than 3 cm below costal margin, yes/no/NA   51/49/3  
Response to prednisone, good poor NA   44/9/50  
Immunophenotype  
Precursor B lineage, male/female   71 (34/37)  
T lineage, male/female
 
32 (20/12)
 

NA indicates not available.

*

Peripheral blood was used only to analyze MRP expression in patients with more than 80% of leukemic cells before and more than 90% after Ficoll-Hypaque density gradient centrifugation.

Less than 109 leukemic cells/L on day 8.

More than 109 leukemic cells/L on day 8.

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