Patient and disease characteristics of children with AML given an unrelated cord blood transplant
Patient characteristics . | . |
|---|---|
| Features at diagnosis | |
| Age, median (range) | 4.8 y (1 mo to 15 y) |
| No. with de novo/secondary AML | 85/10 |
| WBC count | |
| No. evaluable | 91/95 |
| Median (range) | 21.5 × 109/L (0.8-509 × 109/L) |
| No. with WBC greater than 50 × 109/L (%) | 29 (32) |
| FAB subtype | |
| No. evaluable | 89/95 |
| M0/M1/M2/M3 | 9/9/18/5 |
| M4/M5/M6/M7 | 16/21/3/8 |
| CNS involvement (%) | 4 (4) |
| Cytogenetics (%) | |
| No. evaluable | 81/95 |
| Abnormal | 58 (72) |
| Relatively favorable risk | 8 (10) |
| Intermediate risk | 21 (26) |
| Poor risk | 29 (36) |
| Normal | 23 (28) |
| Features at unrelated cord blood transplantation | |
| Age, median (range) | 6 y (4 mo to 16 y) |
| Recipient's weight, median (range) | 21 kg (4.4-78 kg) |
| CMV serology | |
| No. evaluable | 94/95 |
| Negative (%) | 49 (52) |
| Positive (%) | 45 (48) |
| Status (%) | |
| Standard-risk category | |
| First CR | 20 (21) |
| Second CR | 47 (50) |
| High-risk category | |
| Third or subsequent CR | 5 (5) |
| Without CR | 23 (24) |
Patient characteristics . | . |
|---|---|
| Features at diagnosis | |
| Age, median (range) | 4.8 y (1 mo to 15 y) |
| No. with de novo/secondary AML | 85/10 |
| WBC count | |
| No. evaluable | 91/95 |
| Median (range) | 21.5 × 109/L (0.8-509 × 109/L) |
| No. with WBC greater than 50 × 109/L (%) | 29 (32) |
| FAB subtype | |
| No. evaluable | 89/95 |
| M0/M1/M2/M3 | 9/9/18/5 |
| M4/M5/M6/M7 | 16/21/3/8 |
| CNS involvement (%) | 4 (4) |
| Cytogenetics (%) | |
| No. evaluable | 81/95 |
| Abnormal | 58 (72) |
| Relatively favorable risk | 8 (10) |
| Intermediate risk | 21 (26) |
| Poor risk | 29 (36) |
| Normal | 23 (28) |
| Features at unrelated cord blood transplantation | |
| Age, median (range) | 6 y (4 mo to 16 y) |
| Recipient's weight, median (range) | 21 kg (4.4-78 kg) |
| CMV serology | |
| No. evaluable | 94/95 |
| Negative (%) | 49 (52) |
| Positive (%) | 45 (48) |
| Status (%) | |
| Standard-risk category | |
| First CR | 20 (21) |
| Second CR | 47 (50) |
| High-risk category | |
| Third or subsequent CR | 5 (5) |
| Without CR | 23 (24) |
WBC indicates white blood cell; FAB, French-American-British classification; CNS, central nervous system; CMV, cytomegalovirus; and CR, complete remission.