Adverse events
. | All grades, % (no.) . | Grades 3-4, % (no.) . |
|---|---|---|
| Nonhematologic toxicity* | ||
| Nausea | 83 (25) | 0 (0) |
| Asthenia | 70 (21) | 7 (2) |
| Vomiting | 63 (19) | 13 (4) |
| Abdominal pain | 53 (18) | 10 (3) |
| Musculoskeletal pain | 50 (15) | 0 (0) |
| Superficial edema | 50 (15) | 0 (0) |
| Diarrhea | 40 (12) | 0 (0) |
| Muscle cramps | 37 (11) | 0 (0) |
| Headache | 30 (9) | 0 (0) |
| Nasopharyngitis | 27 (8) | 0 (0) |
| Skin rash | 23 (7) | 0 (0) |
| Anorexia | 13 (4) | 0 (0) |
| Pruritus | 13 (4) | 0 (0) |
| Mucositis | 13 (4) | 0 (0) |
| Neurologic symptoms | 3 (1) | 0 (0) |
| Hematologic toxicity† | ||
| Anemia | 10 (3) | 7 (2) |
| Neutropenia | 53 (16) | 27 (8) |
| Thrombocytopenia | 50 (15) | 37 (11) |
. | All grades, % (no.) . | Grades 3-4, % (no.) . |
|---|---|---|
| Nonhematologic toxicity* | ||
| Nausea | 83 (25) | 0 (0) |
| Asthenia | 70 (21) | 7 (2) |
| Vomiting | 63 (19) | 13 (4) |
| Abdominal pain | 53 (18) | 10 (3) |
| Musculoskeletal pain | 50 (15) | 0 (0) |
| Superficial edema | 50 (15) | 0 (0) |
| Diarrhea | 40 (12) | 0 (0) |
| Muscle cramps | 37 (11) | 0 (0) |
| Headache | 30 (9) | 0 (0) |
| Nasopharyngitis | 27 (8) | 0 (0) |
| Skin rash | 23 (7) | 0 (0) |
| Anorexia | 13 (4) | 0 (0) |
| Pruritus | 13 (4) | 0 (0) |
| Mucositis | 13 (4) | 0 (0) |
| Neurologic symptoms | 3 (1) | 0 (0) |
| Hematologic toxicity† | ||
| Anemia | 10 (3) | 7 (2) |
| Neutropenia | 53 (16) | 27 (8) |
| Thrombocytopenia | 50 (15) | 37 (11) |
The total number of side effects exceeds the total number of patients because several side effects occurred in the same patients.
The total number of patients who experienced a nonhematologic grade 3 or 4 toxicity was 7.
The total number of patients who experienced a hematologic grade 3 or 4 toxicity was 16.