Table 1. NFAT-dependent genes with... | American Society of Hematology

Table 1.

NFAT-dependent genes with differential expression in UCB versus AB CD4⁺ T cells

Gene symbol	Accession no.	Gene name	0 h	6 h	16 h
p21	NM_000389	Cyclin-dependent kinase inhibitor 1A (p21, Cip 1)	—	−2.64^*	− 2.46^*
CSF2 (GM-CSF)	M11734	Colony-stimulating factor 2 (granulocyte-macrophage)	—	−6.96^*	−2.14^*
CTLA-4	NM_005214	Cytotoxic T-lymphocyte-associated protein 4	—	−4.00^*	−5.28^*
CTLA-4	BG536887	Cytotoxic T-lymphocyte-associated protein 4	−2.30^*	−4.92^*	−6.50^*
CTLA-4	U90273	Cytotoxic T-lymphocyte-associated protein 4	−2.30^*	−4.92^*	−7.46^*
CTLA-4	AI733018	Cytotoxic T-lymphocyte-associated protein 4	−3.25^*	−5.28^*	−6.06^*
IFN-γ	M29383	Interferon, gamma	−2.14^*	−10.56^*	−9.19^*
IL-2Rα	NM_000417	Interleukin 2 receptor, alpha	−2.14^*	—	—
IL-3	NM_000588	Interleukin 3 (colony-stimulating factor, multiple)	—	−12.13^*	−5.66^*
IL-4	NM_000589	Interleukin 4	—	−6.50^*	−3.73^*
IL-4	NM_000589	Interleukin 4	—	−8.00^*	−4.00^*
IL-5	NM_000879	Interleukin 5 (colony-stimulating factor, eosinophil)	—	−17.15^*	−8.00^*
IL-13	NM_002188	Interleukin 13	—	−3.73^*	−3.48^*
TNF	NM_000594	Tumor necrosis factor (TNF superfamily, member 2)	—	−2.46^*	—
TNFSF5 (CD40L)	NM000074	Tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)	—	−2.30^*	−2.30^*
MIP-1α	NM_002983	CCL2	—	−4.59^*	−4.00^*
CCNA2	NM_001237	Cyclin A2	—	—	8.57
CCNE2	AF112857	Cyclin E2	—	—	2.46
CCNE2	NM_004702	Cyclin E2	—	—	3.25

Gene symbol	Accession no.	Gene name	0 h	6 h	16 h
p21	NM_000389	Cyclin-dependent kinase inhibitor 1A (p21, Cip 1)	—	−2.64^*	− 2.46^*
CSF2 (GM-CSF)	M11734	Colony-stimulating factor 2 (granulocyte-macrophage)	—	−6.96^*	−2.14^*
CTLA-4	NM_005214	Cytotoxic T-lymphocyte-associated protein 4	—	−4.00^*	−5.28^*
CTLA-4	BG536887	Cytotoxic T-lymphocyte-associated protein 4	−2.30^*	−4.92^*	−6.50^*
CTLA-4	U90273	Cytotoxic T-lymphocyte-associated protein 4	−2.30^*	−4.92^*	−7.46^*
CTLA-4	AI733018	Cytotoxic T-lymphocyte-associated protein 4	−3.25^*	−5.28^*	−6.06^*
IFN-γ	M29383	Interferon, gamma	−2.14^*	−10.56^*	−9.19^*
IL-2Rα	NM_000417	Interleukin 2 receptor, alpha	−2.14^*	—	—
IL-3	NM_000588	Interleukin 3 (colony-stimulating factor, multiple)	—	−12.13^*	−5.66^*
IL-4	NM_000589	Interleukin 4	—	−6.50^*	−3.73^*
IL-4	NM_000589	Interleukin 4	—	−8.00^*	−4.00^*
IL-5	NM_000879	Interleukin 5 (colony-stimulating factor, eosinophil)	—	−17.15^*	−8.00^*
IL-13	NM_002188	Interleukin 13	—	−3.73^*	−3.48^*
TNF	NM_000594	Tumor necrosis factor (TNF superfamily, member 2)	—	−2.46^*	—
TNFSF5 (CD40L)	NM000074	Tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)	—	−2.30^*	−2.30^*
MIP-1α	NM_002983	CCL2	—	−4.59^*	−4.00^*
CCNA2	NM_001237	Cyclin A2	—	—	8.57
CCNE2	AF112857	Cyclin E2	—	—	2.46
CCNE2	NM_004702	Cyclin E2	—	—	3.25

Criteria for inclusion were as follows: at least one present (P) call and FC ≥ 2 and change call ≠ no change (NC). A negative number (^*) indicates lower expression in UCB than AB; a positive number, higher expression in UCB than AB; —, the gene did not meet inclusion criteria at that time point; and genes with multiple results indicate multiple probe sets for that gene on the microarray.

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