NFAT-pathway-associated genes with differential expression in UCB versus AB CD4+ T cells
Gene symbol . | Accession no. . | Gene name . | 0 h . | 6 h . | 16 h . | |
|---|---|---|---|---|---|---|
| NFAT family members | ||||||
| NFAT5 | W61007 | Nuclear factor of activated T cells 5, tonicity responsive | — | −2.14* | — | |
| NFATC1 | U08015 | Nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 1 | — | — | 2.00 | |
| NFAT-activating receptors | — | — | — | |||
| FCER1α | BC005912 | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | −2.30* | — | — | |
| Signaling molecules | ||||||
| PAK1 | AU147145 | p21/Cdc42/Rac1-activated kinase 1 | 2.00 | — | — | |
| PAK1 | U51120 | p21/Cdc42/Rac1-activated kinase 1 | 4.92 | — | 3.25 | |
| PAK1 | AU154408 | p21/Cdc42/Rac1-activated kinase 1 | — | 2.14 | — | |
| Vav3 | AF118887 | Vav3 oncogene | — | 3.73 | — | |
| Vav3 | NM_006113 | Vav3 oncogene | — | 2.83 | — | |
| CALM2 | BF591288 | Calmodulin 2 (phosphorylase kinase, delta) | — | −2.00* | — | |
| CAMK4 | AL529104 | Calcium/calmodulin-dependent protein kinase IV | — | — | −2.00* | |
| NFAT/Ca2+-signaling inhibitors | ||||||
| SLA | U44403 | Src-like adaptor | — | −3.25* | −2.64* | |
| SLA | NM_006748 | Src-like adaptor | — | −2.00* | −2.30* | |
| Related transcription factors | ||||||
| C/EBPβ | AL564683 | CCAAT/enhancer binding protein (C/EBP), beta | — | −2.00* | — | |
| JUNB | NM_002229 | JunB proto-oncogene | — | −2.46* | — | |
| NFKBIE (IκBϵ) | BG163267 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | — | −2.00* | — | |
| FOSL1 (Fra-1) | BG251266 | FOS-like antigen 1 | — | — | −2.64* | |
Gene symbol . | Accession no. . | Gene name . | 0 h . | 6 h . | 16 h . | |
|---|---|---|---|---|---|---|
| NFAT family members | ||||||
| NFAT5 | W61007 | Nuclear factor of activated T cells 5, tonicity responsive | — | −2.14* | — | |
| NFATC1 | U08015 | Nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 1 | — | — | 2.00 | |
| NFAT-activating receptors | — | — | — | |||
| FCER1α | BC005912 | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | −2.30* | — | — | |
| Signaling molecules | ||||||
| PAK1 | AU147145 | p21/Cdc42/Rac1-activated kinase 1 | 2.00 | — | — | |
| PAK1 | U51120 | p21/Cdc42/Rac1-activated kinase 1 | 4.92 | — | 3.25 | |
| PAK1 | AU154408 | p21/Cdc42/Rac1-activated kinase 1 | — | 2.14 | — | |
| Vav3 | AF118887 | Vav3 oncogene | — | 3.73 | — | |
| Vav3 | NM_006113 | Vav3 oncogene | — | 2.83 | — | |
| CALM2 | BF591288 | Calmodulin 2 (phosphorylase kinase, delta) | — | −2.00* | — | |
| CAMK4 | AL529104 | Calcium/calmodulin-dependent protein kinase IV | — | — | −2.00* | |
| NFAT/Ca2+-signaling inhibitors | ||||||
| SLA | U44403 | Src-like adaptor | — | −3.25* | −2.64* | |
| SLA | NM_006748 | Src-like adaptor | — | −2.00* | −2.30* | |
| Related transcription factors | ||||||
| C/EBPβ | AL564683 | CCAAT/enhancer binding protein (C/EBP), beta | — | −2.00* | — | |
| JUNB | NM_002229 | JunB proto-oncogene | — | −2.46* | — | |
| NFKBIE (IκBϵ) | BG163267 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | — | −2.00* | — | |
| FOSL1 (Fra-1) | BG251266 | FOS-like antigen 1 | — | — | −2.64* | |
Criteria for inclusion were as follows: at least one present (P) call and FC ≥ 2 and change call ≠ no change (NC). A negative number (*) indicates lower expression in UCB than AB; a positive number, higher expression in UCB than AB;—, the gene did not meet inclusion criteria at that time point; and genes with multiple results indicate multiple probe sets for that gene on the microarray.