Table 3. Differential expression of... | American Society of Hematology

Table 3.

Differential expression of cytokine and cytokine receptor genes in UCB versus AB CD4⁺T cells

Gene symbol	Accession no.	Gene name	0 h	6 h	16 h
Cytokines
IL-1β	NM_000576	Interleukin 1, beta	—	−3.48^*	−2.00^*
IL-1β	M15330	Interleukin 1, beta	—	−3.03^*
IL-3	NM_000588	Interleukin 3 (colony-stimulating factor, multiple)	—	−12.13^*	−5.66^*
IL-4	NM_000589	Interleukin 4	—	−6.50^*	−3.73^*
IL-4	NM_000589	Interleukin 4	—	−8.00^*	−4.00^*
IL-5	NM_000879	Interleukin 5 (colony-stimulating factor, eosinophil)	—	−17.15^*	−8.00^*
IL-9	NM_000590	Interleukin 9	—	−6.96^*	−548.75^*
IL-10	NM_000572	Interleukin 10	—	−16.00^*	−27.86^*
IL-13	NM_002188	Interleukin 13	—	−3.73^*	−3.48^*
IL-15	NM_000585	Interleukin 15	−2.83^*	−3.48^*	−2.14^*
IL-16	NM_004513	Interleukin 16 (lymphocyte chemoattractant factor)	—	3.48	3.03
IL-16	M90391	Interleukin 16 (lymphocyte chemoattractant factor)	—	2.83	2.64
IL-17	Z58820	Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)	—	−84.45^*	−675.59^*
IL-21	NM_021803	Interleukin 21	—	−7.46^*	−8.00^*
IL-22	NM_020525	Interleukin 22	—	−13.00^*	−27.86^*
IL-22	AF279437	Interleukin 22	—	−39.40^*	−512.00^*
IL-26	NM_018402	Interleukin 26	—	—	−207.94^*
Cytokine receptors
IL-1RN	BE563442	Interleukin 1 receptor antagonist	—	−2.00^*	—
IL-1RN	AW083357	Interleukin 1 receptor antagonist	—	−2.46^*	—
IL-1RN	AW083357	Interleukin 1 receptor antagonist	—	−2.30^*	—
IL-1R1	NM_000877	Interleukin 1 receptor, type 1	—	−2.30^*	−2.00^*
IL-1R2	NM_004633	Interleukin 1 receptor, type II	—	−3.48^*	—
IL-1R2	U64094	Interleukin 1 receptor, type II	—	—	−2.64^*
IL-2Rα	NM_000417	Interleukin 2 receptor, alpha	−2.14^*	—	—
IL-2Rβ	NM_000878	Interleukin 2 receptor, beta	−2.83^*	−2.30^*	—
IL-6R	NM_000565	Interleukin 6 receptor	—	−2.46^*	—
IL-6R	S72848	Interleukin 6 receptor	—	—	−3.25^*
IL-6R	AV700030	Interleukin 6 receptor	—	−2.46^*	−4.59^*
IL-7R	NM_002185	Interleukin 7 receptor	—	—	−2.64^*
IL-10Rα	NM_001558	Interleukin 10 receptor, alpha	−2.64^*	−4.29^*	−2.46^*
IL-17BR	AF250309	Interleukin 17B receptor	—	−8.57^*	—
IL-18R1	NM_003855	Interleukin 18 receptor 1	−2.30^*	—	—
IL-18RAP	NM_003853	Interleukin 18 receptor accessory protein	−6.06^*	−2.14^*	−2.83^*

Gene symbol	Accession no.	Gene name	0 h	6 h	16 h
Cytokines
IL-1β	NM_000576	Interleukin 1, beta	—	−3.48^*	−2.00^*
IL-1β	M15330	Interleukin 1, beta	—	−3.03^*
IL-3	NM_000588	Interleukin 3 (colony-stimulating factor, multiple)	—	−12.13^*	−5.66^*
IL-4	NM_000589	Interleukin 4	—	−6.50^*	−3.73^*
IL-4	NM_000589	Interleukin 4	—	−8.00^*	−4.00^*
IL-5	NM_000879	Interleukin 5 (colony-stimulating factor, eosinophil)	—	−17.15^*	−8.00^*
IL-9	NM_000590	Interleukin 9	—	−6.96^*	−548.75^*
IL-10	NM_000572	Interleukin 10	—	−16.00^*	−27.86^*
IL-13	NM_002188	Interleukin 13	—	−3.73^*	−3.48^*
IL-15	NM_000585	Interleukin 15	−2.83^*	−3.48^*	−2.14^*
IL-16	NM_004513	Interleukin 16 (lymphocyte chemoattractant factor)	—	3.48	3.03
IL-16	M90391	Interleukin 16 (lymphocyte chemoattractant factor)	—	2.83	2.64
IL-17	Z58820	Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)	—	−84.45^*	−675.59^*
IL-21	NM_021803	Interleukin 21	—	−7.46^*	−8.00^*
IL-22	NM_020525	Interleukin 22	—	−13.00^*	−27.86^*
IL-22	AF279437	Interleukin 22	—	−39.40^*	−512.00^*
IL-26	NM_018402	Interleukin 26	—	—	−207.94^*
Cytokine receptors
IL-1RN	BE563442	Interleukin 1 receptor antagonist	—	−2.00^*	—
IL-1RN	AW083357	Interleukin 1 receptor antagonist	—	−2.46^*	—
IL-1RN	AW083357	Interleukin 1 receptor antagonist	—	−2.30^*	—
IL-1R1	NM_000877	Interleukin 1 receptor, type 1	—	−2.30^*	−2.00^*
IL-1R2	NM_004633	Interleukin 1 receptor, type II	—	−3.48^*	—
IL-1R2	U64094	Interleukin 1 receptor, type II	—	—	−2.64^*
IL-2Rα	NM_000417	Interleukin 2 receptor, alpha	−2.14^*	—	—
IL-2Rβ	NM_000878	Interleukin 2 receptor, beta	−2.83^*	−2.30^*	—
IL-6R	NM_000565	Interleukin 6 receptor	—	−2.46^*	—
IL-6R	S72848	Interleukin 6 receptor	—	—	−3.25^*
IL-6R	AV700030	Interleukin 6 receptor	—	−2.46^*	−4.59^*
IL-7R	NM_002185	Interleukin 7 receptor	—	—	−2.64^*
IL-10Rα	NM_001558	Interleukin 10 receptor, alpha	−2.64^*	−4.29^*	−2.46^*
IL-17BR	AF250309	Interleukin 17B receptor	—	−8.57^*	—
IL-18R1	NM_003855	Interleukin 18 receptor 1	−2.30^*	—	—
IL-18RAP	NM_003853	Interleukin 18 receptor accessory protein	−6.06^*	−2.14^*	−2.83^*

Criteria for inclusion were as follows: at least one present (P) call and FC ≥ 2 and change call ≠ no change (NC). A negative number (^*) indicates lower expression in UCB than AB; a positive number indicates higher expression in UCB than AB;—, the gene did not meet inclusion criteria at that time point; and genes with multiple results indicate multiple probe sets for that gene on the microarray.

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