Characteristics of cord blood units and transplantation outcomes
Case . | Cord blood cell dose × 107/kg, cryopreserved . | No. of HLA-A, -B, -DRB1 mismatches . | Neutrophil count more than 0.5 × 109/L, d . | Reticulocyte count more than 1%, d . | Hemoglobin level more than 8.5 g/dL, d . | Platelet count more than 50 × 109/L, d . | Acute GVHD grade (organ involvement and stage) . | Chronic GVHD . | Survival, d* . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 1.63 | 1 (DRB1) | NE | NE | NE | NE | NE | NE | 27 |
| 2 | 1.16 | 2 (A, B) | 41 | 67 | NE | NE | II (skin 3, liver 1, gut 0) | Extensive | 260 |
| 3 | 2.04 | 3 (A, DRB1, DRB1) | 25 | 33 | 38 | 56 | II (skin 3, liver 0, gut 1) | Limited | 1332+ |
| 4 | 2.25 | 2 (B, DRB1) | 20 | 24 | 59 | 31 | II (skin 1, liver 0, gut 1) | Limited | 1318+ |
| 5 | 3.3 | 2 (DRB1, DRB1) | 21 | 28 | 33 | 52 | I (skin 2, liver 0, gut 0) | Limited | 1130+ |
| 6 | 5.29 | 1 (DRB1) | 28 | 33 | 67 | 53 | II (skin 3, liver 0, gut 1) | None | 648 |
| 7 | 3 | 2 (B, DRB1) | 24 | 34 | 97 | 46 | I (skin 1, liver 0, gut 0) | Limited | 926+ |
| 8 | 2.57 | 3 (B, B, DRB1) | 20 | 34 | 22 | 39 | II (skin 3, liver 0, gut 0) | Extensive | 919+ |
| 9 | 3.71 | 1 (DRB1) | 26 | 46 | 63 | 81 | II (skin 3, liver 0, gut 0) | None | 202 |
| 10 | 2.21 | 2 (B, DRB1) | 23 | 32 | 76 | 44 | I (skin 1, liver 0, gut 0) | None | 815+ |
| 11 | 3.31 | 2 (B, DRB1) | 20 | 26 | 16 | 36 | II (skin 3, liver 0, gut 1) | Limited | 640+ |
| 12 | 2.44 | 2 (A, DRB1) | 21 | 32 | 308 | 130 | I (skin 2, liver 0, gut 0) | Limited | 542+ |
| 13 | 2.34 | 2 (B, DRB1) | 26 | 43 | 270 | 263 | II (skin 3, liver 0, gut 1) | Extensive | 535+ |
| 14 | 2.6 | 3 (B, B, DRB1) | 34 | 96 | 111 | 109 | II (skin 2, liver 0, gut 1) | Limited | 493+ |
| 15 | 2.23 | 4 (A, B, DRB1, DRB1) | 22 | 28 | 22 | 35 | I (skin 2, liver 0, gut 0) | Limited | 436+ |
| 16 | 3.93 | 2 (B, DRB1) | 16 | 21 | 24 | 37 | II (skin 1, liver 0, gut 1) | Limited | 430+ |
| 17 | 2.23 | 1 (DRB1) | 24 | 35 | 76 | 46 | 0 | Limited | 381+ |
| 18 | 3.33 | 3 (B, DRB1, DRB1) | 23 | 41 | 69 | 116 | III (skin 3, liver 0, gut 3) | Limited | 185+ |
Case . | Cord blood cell dose × 107/kg, cryopreserved . | No. of HLA-A, -B, -DRB1 mismatches . | Neutrophil count more than 0.5 × 109/L, d . | Reticulocyte count more than 1%, d . | Hemoglobin level more than 8.5 g/dL, d . | Platelet count more than 50 × 109/L, d . | Acute GVHD grade (organ involvement and stage) . | Chronic GVHD . | Survival, d* . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 1.63 | 1 (DRB1) | NE | NE | NE | NE | NE | NE | 27 |
| 2 | 1.16 | 2 (A, B) | 41 | 67 | NE | NE | II (skin 3, liver 1, gut 0) | Extensive | 260 |
| 3 | 2.04 | 3 (A, DRB1, DRB1) | 25 | 33 | 38 | 56 | II (skin 3, liver 0, gut 1) | Limited | 1332+ |
| 4 | 2.25 | 2 (B, DRB1) | 20 | 24 | 59 | 31 | II (skin 1, liver 0, gut 1) | Limited | 1318+ |
| 5 | 3.3 | 2 (DRB1, DRB1) | 21 | 28 | 33 | 52 | I (skin 2, liver 0, gut 0) | Limited | 1130+ |
| 6 | 5.29 | 1 (DRB1) | 28 | 33 | 67 | 53 | II (skin 3, liver 0, gut 1) | None | 648 |
| 7 | 3 | 2 (B, DRB1) | 24 | 34 | 97 | 46 | I (skin 1, liver 0, gut 0) | Limited | 926+ |
| 8 | 2.57 | 3 (B, B, DRB1) | 20 | 34 | 22 | 39 | II (skin 3, liver 0, gut 0) | Extensive | 919+ |
| 9 | 3.71 | 1 (DRB1) | 26 | 46 | 63 | 81 | II (skin 3, liver 0, gut 0) | None | 202 |
| 10 | 2.21 | 2 (B, DRB1) | 23 | 32 | 76 | 44 | I (skin 1, liver 0, gut 0) | None | 815+ |
| 11 | 3.31 | 2 (B, DRB1) | 20 | 26 | 16 | 36 | II (skin 3, liver 0, gut 1) | Limited | 640+ |
| 12 | 2.44 | 2 (A, DRB1) | 21 | 32 | 308 | 130 | I (skin 2, liver 0, gut 0) | Limited | 542+ |
| 13 | 2.34 | 2 (B, DRB1) | 26 | 43 | 270 | 263 | II (skin 3, liver 0, gut 1) | Extensive | 535+ |
| 14 | 2.6 | 3 (B, B, DRB1) | 34 | 96 | 111 | 109 | II (skin 2, liver 0, gut 1) | Limited | 493+ |
| 15 | 2.23 | 4 (A, B, DRB1, DRB1) | 22 | 28 | 22 | 35 | I (skin 2, liver 0, gut 0) | Limited | 436+ |
| 16 | 3.93 | 2 (B, DRB1) | 16 | 21 | 24 | 37 | II (skin 1, liver 0, gut 1) | Limited | 430+ |
| 17 | 2.23 | 1 (DRB1) | 24 | 35 | 76 | 46 | 0 | Limited | 381+ |
| 18 | 3.33 | 3 (B, DRB1, DRB1) | 23 | 41 | 69 | 116 | III (skin 3, liver 0, gut 3) | Limited | 185+ |
Cases 2, 6, and 9 relapsed on day 249, day 406, and day 175. GVHD indicates graft-versus-host disease; and NE, not evaluable.
Fourteen patients are alive in complete remission at the time of writing.