Table 2.

Circulating F.IX levels 8 weeks after intramuscular injection of AAV vectors in mice


Vector dose, vg/kg

AAV-1

AAV-2

Fold difference
2 × 1011  198 ± 96   19 ± 3   10.4  
1 × 1012  436 ± 79   20 ± 5   21.8  
4 × 1012
 
1115 ± 120
 
53 ± 10
 
21.0
 

Vector dose, vg/kg

AAV-1

AAV-2

Fold difference
2 × 1011  198 ± 96   19 ± 3   10.4  
1 × 1012  436 ± 79   20 ± 5   21.8  
4 × 1012
 
1115 ± 120
 
53 ± 10
 
21.0
 

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