Cytogenetic and hematologic responses
Response . | ALL patients, n = 141 . | Evaluable patients, n . |
|---|---|---|
| Cytogenetic response, no. (%) | ||
| Major | ||
| Complete | 45 (32) | 45 |
| Partial | 23 (16) | 23 |
| Minor | 4 (3) | 4 |
| Minimal | 69 (49) | 69 |
| Complete cytogenetic response, % (SE) | ||
| At 6 mo | 21.1 (3.5) | 107 |
| At 9 mo | 27.3 (3.8) | 89 |
| At 12 mo | 32.4 (4.2) | 59 |
| At 18 mo | 36.6 (4.6) | 32 |
| Major cytogenetic response, % (SE) | ||
| At 6 mo | 31.2 (4.0) | 93 |
| At 9 mo | 39.7 (4.2) | 74 |
| At 12 mo | 45.8 (4.5) | 49 |
| At 18 mo | 55.0 (4.9) | 24 |
| Complete hematologic response, % (SE) | ||
| At 6 mo | 95.0 (1.8) | 7 |
| At 12 mo | 96.5 (1.6) | 5 |
| At 18 mo | 98.6 (1.0) | 2 |
| Hematologic relapse, % (SE) | ||
| At 6 mo | 2.9 (1.4) | 132 |
| At 12 mo | 10.9 (2.8) | 83 |
| At 18 mo | 14.6 (3.4) | 54 |
| Duration of response, % (SE) | ||
| At 6 mo | 5.8 (0.2) | 127 |
| At 12 mo | 12.9 (3.1) | 72 |
| At 18 mo | 15.6 (3.5) | 48 |
Response . | ALL patients, n = 141 . | Evaluable patients, n . |
|---|---|---|
| Cytogenetic response, no. (%) | ||
| Major | ||
| Complete | 45 (32) | 45 |
| Partial | 23 (16) | 23 |
| Minor | 4 (3) | 4 |
| Minimal | 69 (49) | 69 |
| Complete cytogenetic response, % (SE) | ||
| At 6 mo | 21.1 (3.5) | 107 |
| At 9 mo | 27.3 (3.8) | 89 |
| At 12 mo | 32.4 (4.2) | 59 |
| At 18 mo | 36.6 (4.6) | 32 |
| Major cytogenetic response, % (SE) | ||
| At 6 mo | 31.2 (4.0) | 93 |
| At 9 mo | 39.7 (4.2) | 74 |
| At 12 mo | 45.8 (4.5) | 49 |
| At 18 mo | 55.0 (4.9) | 24 |
| Complete hematologic response, % (SE) | ||
| At 6 mo | 95.0 (1.8) | 7 |
| At 12 mo | 96.5 (1.6) | 5 |
| At 18 mo | 98.6 (1.0) | 2 |
| Hematologic relapse, % (SE) | ||
| At 6 mo | 2.9 (1.4) | 132 |
| At 12 mo | 10.9 (2.8) | 83 |
| At 18 mo | 14.6 (3.4) | 54 |
| Duration of response, % (SE) | ||
| At 6 mo | 5.8 (0.2) | 127 |
| At 12 mo | 12.9 (3.1) | 72 |
| At 18 mo | 15.6 (3.5) | 48 |
*The level of cytogenetic response was defined by the percentage of Ph+ cells in metaphase; complete response, 0%; partial response, 1% to 35%; minor response, 36% to 65%; minimal response, 66% to 95%; no response, more than 95%. A major cytogenetic response was defined as a complete or partial response. Duration of response is the time interval between day of complete hematologic response and day of loss of hematologic response or day of last contact, whichever occurred first.