Prognostic factors associated with hematologic relapse
Variable . | No. of patients . | Patients with hematologic relapse, no. (%) . | P by univariate analysis . | P by multivariate analysis . | Hazard ratio . | 95% CI . |
|---|---|---|---|---|---|---|
| Response to IFN therapy | ||||||
| Hematologic failure | 46 | 6 (13) | ||||
| Cytogenetic failure | 35 | 8 (23) | .3219 | — | — | — |
| IFN intolerance | 60 | 8 (13) | .5886 | — | — | — |
| Age | .8263 | — | — | — | ||
| Younger than 60 y | 76 | 12 (16) | ||||
| 60 y or older | 65 | 10 (15) | ||||
| Sex | .7686 | — | — | — | ||
| Male | 77 | 11 (14) | ||||
| Female | 64 | 11 (17) | ||||
| Weight | .4729 | — | — | — | ||
| Less than 70 kg | 47 | 6 (13) | ||||
| 70 kg or more | 94 | 16 (17) | ||||
| Splenomegaly | .2110 | — | — | — | ||
| No | 95 | 12 (13) | ||||
| Yes | 46 | 10 (22) | ||||
| Time since diagnosis of CML | .9465 | — | — | — | ||
| Less than 3 y | 71 | 11 (15) | ||||
| 3 y or more | 70 | 11 (16) | ||||
| Hemoglobin level | .0198 | — | — | — | ||
| Less than 120 g/L | 44 | 11 (25) | ||||
| 120 g/L or more | 89 | 9 (10) | ||||
| WBC count | .6480 | — | — | — | ||
| Less than 10 × 109/L | 44 | 7 (16) | ||||
| 10 × 109/L or more | 97 | 15 (15) | ||||
| Platelet count | .1354 | — | — | — | ||
| Less than 450 × 109/L | 91 | 11 (12) | ||||
| 450 × 109/L or more | 50 | 11 (22) | ||||
| Basophils | .1730 | — | — | — | ||
| Less than 7% | 108 | 14 (13) | ||||
| 7% or more | 33 | 8 (24) | ||||
| Bands | .0142 | — | — | — | ||
| Less than 6% | 81 | 7 (9) | ||||
| 6% or more | 59 | 14 (24) | ||||
| Blasts in peripheral blood | .0823 | — | — | — | ||
| 0% | 128 | 18 (14) | ||||
| More than 0% | 11 | 4 (36) | ||||
| Blasts in bone marrow | .1141 | — | — | — | ||
| Less than 5% | 110 | 14 (13) | ||||
| 5% or more | 30 | 7 (23) | ||||
| Ph+ cells in metaphase | — | — | — | |||
| Less than 99% | 20 | 2 (10) | .2478 | |||
| 99% or more | 118 | 20 (17) | ||||
| Clonal evolution | < .0001 | .0008 | 1.944-12.409 | |||
| No | 119 | 11 (9) | 1.000 | |||
| Yes | 22 | 11 (50) | 4.912 | |||
| Myelosupression | .4577 | — | — | — | ||
| No | 114 | 16 (14) | ||||
| Yes | 26 | 5 (19) | ||||
| Major cytogenetic response | .0047 | .0339 | 0.042-0.883 | |||
| No | 77 | 20 (26) | 1.000 | |||
| Yes | 64 | 2 (3) | 0.193 |
Variable . | No. of patients . | Patients with hematologic relapse, no. (%) . | P by univariate analysis . | P by multivariate analysis . | Hazard ratio . | 95% CI . |
|---|---|---|---|---|---|---|
| Response to IFN therapy | ||||||
| Hematologic failure | 46 | 6 (13) | ||||
| Cytogenetic failure | 35 | 8 (23) | .3219 | — | — | — |
| IFN intolerance | 60 | 8 (13) | .5886 | — | — | — |
| Age | .8263 | — | — | — | ||
| Younger than 60 y | 76 | 12 (16) | ||||
| 60 y or older | 65 | 10 (15) | ||||
| Sex | .7686 | — | — | — | ||
| Male | 77 | 11 (14) | ||||
| Female | 64 | 11 (17) | ||||
| Weight | .4729 | — | — | — | ||
| Less than 70 kg | 47 | 6 (13) | ||||
| 70 kg or more | 94 | 16 (17) | ||||
| Splenomegaly | .2110 | — | — | — | ||
| No | 95 | 12 (13) | ||||
| Yes | 46 | 10 (22) | ||||
| Time since diagnosis of CML | .9465 | — | — | — | ||
| Less than 3 y | 71 | 11 (15) | ||||
| 3 y or more | 70 | 11 (16) | ||||
| Hemoglobin level | .0198 | — | — | — | ||
| Less than 120 g/L | 44 | 11 (25) | ||||
| 120 g/L or more | 89 | 9 (10) | ||||
| WBC count | .6480 | — | — | — | ||
| Less than 10 × 109/L | 44 | 7 (16) | ||||
| 10 × 109/L or more | 97 | 15 (15) | ||||
| Platelet count | .1354 | — | — | — | ||
| Less than 450 × 109/L | 91 | 11 (12) | ||||
| 450 × 109/L or more | 50 | 11 (22) | ||||
| Basophils | .1730 | — | — | — | ||
| Less than 7% | 108 | 14 (13) | ||||
| 7% or more | 33 | 8 (24) | ||||
| Bands | .0142 | — | — | — | ||
| Less than 6% | 81 | 7 (9) | ||||
| 6% or more | 59 | 14 (24) | ||||
| Blasts in peripheral blood | .0823 | — | — | — | ||
| 0% | 128 | 18 (14) | ||||
| More than 0% | 11 | 4 (36) | ||||
| Blasts in bone marrow | .1141 | — | — | — | ||
| Less than 5% | 110 | 14 (13) | ||||
| 5% or more | 30 | 7 (23) | ||||
| Ph+ cells in metaphase | — | — | — | |||
| Less than 99% | 20 | 2 (10) | .2478 | |||
| 99% or more | 118 | 20 (17) | ||||
| Clonal evolution | < .0001 | .0008 | 1.944-12.409 | |||
| No | 119 | 11 (9) | 1.000 | |||
| Yes | 22 | 11 (50) | 4.912 | |||
| Myelosupression | .4577 | — | — | — | ||
| No | 114 | 16 (14) | ||||
| Yes | 26 | 5 (19) | ||||
| Major cytogenetic response | .0047 | .0339 | 0.042-0.883 | |||
| No | 77 | 20 (26) | 1.000 | |||
| Yes | 64 | 2 (3) | 0.193 |
— indicates values not shown to be significant on multivariate analysis.