Table 4.

Probability of subsequent major cytogenetic response by 15 mo given no cytogenetic response in earlier months


Month of no response

No. of patients

Probability of subsequent MCR by 15 mo, %

95% CI, %
Ph+ more than 65%    
0   134   51   42, 61  
3   84   35   23, 47  
6   57   24   10, 39  
9   21   24   4, 45  
12   12   10   0, 29  
Ph+ more than 95%    
0   122   48   38, 59  
3   68   28   15, 41  
6   37   17   1, 33  
9   15   10   0, 29  
12
 
10
 
0
 
0, 0
 

Month of no response

No. of patients

Probability of subsequent MCR by 15 mo, %

95% CI, %
Ph+ more than 65%    
0   134   51   42, 61  
3   84   35   23, 47  
6   57   24   10, 39  
9   21   24   4, 45  
12   12   10   0, 29  
Ph+ more than 95%    
0   122   48   38, 59  
3   68   28   15, 41  
6   37   17   1, 33  
9   15   10   0, 29  
12
 
10
 
0
 
0, 0
 

The number of patients indicates those who had more than 65% Ph+ or more than 95% Ph+ at all times prior to or including the month indicated. For example, 134 patients had more than 65% Ph+ at baseline (month = 0) and 57 patients had consistently more than 65% Ph+ prior to or at 6 months (ie, month = 0, 3, or 6). A total of 122 patients had more than 95% Ph+ at baseline (month = 0) and 37 patients had consistently more than 95% Ph+ prior to or at 6 months (ie, month = 0, 3, or 6). MCR indicates major cytogenetic response.

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