Steady-state filgrastim- or lenograstim-primed PBSC mobilization to collect 2.0 × 106/kg or more CD34 cells
. | First mobilization T 178 (69-377) d . | . | Second mobilization T 288 (243-517) d . | . | . | Third mobilization T 573 d . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | CD34 collected × 106/kg . | . | CD34 collected × 106/kg . | . | . | CD34 collected × 106/kg . | . | |||||
| Patients . | No. aphereses . | 1st mob . | No. aphereses . | 2nd mob . | 1st + 2nd mob . | No. aphereses . | 3rd mob . | 2nd + 3rd mob . | |||||
| 1 | 2 | 3.45 | — | — | — | — | — | — | |||||
| 2 | 3 | 2.64 | — | — | — | — | — | — | |||||
| 3 | 3 | 2.60 | — | * | — | — | — | — | |||||
| 4 | 3 | 2.31 | — | — | — | — | — | — | |||||
| 5 | 2 | 2.30 | — | * | — | — | — | — | |||||
| 6 | 4 | 2.21 | — | — | — | — | — | — | |||||
| 7 | 3 | 1.80 | — | — | — | — | — | — | |||||
| 8 | 2 | 1.74 | — | — | — | — | — | — | |||||
| 9 | 2 | 1.48 | 2 | 0.92 | 2.40 | — | — | — | |||||
| 10 | 2 | 1.42 | 2 | 2.20 | 3.62 | — | — | — | |||||
| 11 | 3 | 1.28 | 3 | 1.84 | 2.67 | — | — | — | |||||
| 12 | 2 | 1.27 | 1 | 1.76 | 3.03 | — | — | — | |||||
| 13 | 2 | 0.94 | — | — | — | — | — | — | |||||
| 14 | 2 | 0.83 | — | — | — | — | — | — | |||||
| 15 | 1 | 0.59 | — | — | — | — | — | — | |||||
| 16 | 1 | 0.50 | — | — | — | — | — | — | |||||
| 17 | 1 | 0.47 | — | — | — | — | — | — | |||||
| 18 | 0 | — | 2 | 2.56 | — | — | — | — | |||||
| 19 | 0 | — | 2 | 1.12 | — | 3 | 1.13 | 2.25 | |||||
| 20 | 0 | — | 2 | 0.98 | — | — | — | — | |||||
| 21 | 0 | — | 2 | 0.55 | — | — | — | — | |||||
| 22 | 0 | — | 0 | — | — | — | — | — | |||||
| 23 | 0 | — | 0 | — | — | — | — | — | |||||
| 24 | 0 | — | 0 | — | — | — | — | — | |||||
| 25-38 | 0 | — | — | — | — | — | — | — | |||||
. | First mobilization T 178 (69-377) d . | . | Second mobilization T 288 (243-517) d . | . | . | Third mobilization T 573 d . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | CD34 collected × 106/kg . | . | CD34 collected × 106/kg . | . | . | CD34 collected × 106/kg . | . | |||||
| Patients . | No. aphereses . | 1st mob . | No. aphereses . | 2nd mob . | 1st + 2nd mob . | No. aphereses . | 3rd mob . | 2nd + 3rd mob . | |||||
| 1 | 2 | 3.45 | — | — | — | — | — | — | |||||
| 2 | 3 | 2.64 | — | — | — | — | — | — | |||||
| 3 | 3 | 2.60 | — | * | — | — | — | — | |||||
| 4 | 3 | 2.31 | — | — | — | — | — | — | |||||
| 5 | 2 | 2.30 | — | * | — | — | — | — | |||||
| 6 | 4 | 2.21 | — | — | — | — | — | — | |||||
| 7 | 3 | 1.80 | — | — | — | — | — | — | |||||
| 8 | 2 | 1.74 | — | — | — | — | — | — | |||||
| 9 | 2 | 1.48 | 2 | 0.92 | 2.40 | — | — | — | |||||
| 10 | 2 | 1.42 | 2 | 2.20 | 3.62 | — | — | — | |||||
| 11 | 3 | 1.28 | 3 | 1.84 | 2.67 | — | — | — | |||||
| 12 | 2 | 1.27 | 1 | 1.76 | 3.03 | — | — | — | |||||
| 13 | 2 | 0.94 | — | — | — | — | — | — | |||||
| 14 | 2 | 0.83 | — | — | — | — | — | — | |||||
| 15 | 1 | 0.59 | — | — | — | — | — | — | |||||
| 16 | 1 | 0.50 | — | — | — | — | — | — | |||||
| 17 | 1 | 0.47 | — | — | — | — | — | — | |||||
| 18 | 0 | — | 2 | 2.56 | — | — | — | — | |||||
| 19 | 0 | — | 2 | 1.12 | — | 3 | 1.13 | 2.25 | |||||
| 20 | 0 | — | 2 | 0.98 | — | — | — | — | |||||
| 21 | 0 | — | 2 | 0.55 | — | — | — | — | |||||
| 22 | 0 | — | 0 | — | — | — | — | — | |||||
| 23 | 0 | — | 0 | — | — | — | — | — | |||||
| 24 | 0 | — | 0 | — | — | — | — | — | |||||
| 25-38 | 0 | — | — | — | — | — | — | — | |||||
T indicates time elapsed between the last FDR-CY course and first day of mobilization in median (range); mob, mobilization; and —, not applicable.
Although more than 2.0 × 106/kg CD34 cells were stored after the first mobilization, a second mobilization was performed in patients 3 and 5 at 44 and 108 days after the first mobilization, leading to the harvest of 2.09 and 2.3 × 106/kg CD34 cells, respectively.