Comparison of acute events in children with and without acute HPV B19 infections
. | Univariate analysis . | . | . | Multivariable analysis . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
. | OR . | 95% CI . | P . | OR . | 95% CI . | P . | ||||
| Total study population* | ||||||||||
| ACS | 1.2 | 0.6-2.4 | .57 | 1.8 | 0.9-3.6 | .09 | ||||
| ASS | 9.4 | 5.1-17.4 | <.01 | 11.4 | 5.8-22.1 | <.01 | ||||
| Painful episode | 1.2 | 0.7-1.9 | .36 | 1.9 | 1.1-3.2 | .02 | ||||
| Fever | 2.1 | 1.3-3.4 | <.01 | 3.2 | 1.9-5.6 | <.01 | ||||
| SCD-SC population† | ||||||||||
| ACS | 4.5 | 1.4-14.5 | .01 | 9.3 | 2.0-42.4 | <.01 | ||||
| ASS | 49.5 | 16.4-149.4 | <.01 | 50.7 | 14.1-182.4 | <.01 | ||||
| Painful episode | 2.4 | 0.8-7.0 | .11 | 4.6 | 1.1-18.9 | .03 | ||||
| Fever | 1.7 | 0.6-4.8 | .36 | 5.4 | 1.5-20.4 | .01 | ||||
| Presentation with fever and/or pain‡ | ||||||||||
| ACS | 2.3 | 1.2-4.6 | .02 | 2.3 | 1.1-4.7 | .02 | ||||
| ASS | 12.9 | 6.5-25.2 | <.01 | 13.3 | 6.6-26.8 | <.01 | ||||
. | Univariate analysis . | . | . | Multivariable analysis . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
. | OR . | 95% CI . | P . | OR . | 95% CI . | P . | ||||
| Total study population* | ||||||||||
| ACS | 1.2 | 0.6-2.4 | .57 | 1.8 | 0.9-3.6 | .09 | ||||
| ASS | 9.4 | 5.1-17.4 | <.01 | 11.4 | 5.8-22.1 | <.01 | ||||
| Painful episode | 1.2 | 0.7-1.9 | .36 | 1.9 | 1.1-3.2 | .02 | ||||
| Fever | 2.1 | 1.3-3.4 | <.01 | 3.2 | 1.9-5.6 | <.01 | ||||
| SCD-SC population† | ||||||||||
| ACS | 4.5 | 1.4-14.5 | .01 | 9.3 | 2.0-42.4 | <.01 | ||||
| ASS | 49.5 | 16.4-149.4 | <.01 | 50.7 | 14.1-182.4 | <.01 | ||||
| Painful episode | 2.4 | 0.8-7.0 | .11 | 4.6 | 1.1-18.9 | .03 | ||||
| Fever | 1.7 | 0.6-4.8 | .36 | 5.4 | 1.5-20.4 | .01 | ||||
| Presentation with fever and/or pain‡ | ||||||||||
| ACS | 2.3 | 1.2-4.6 | .02 | 2.3 | 1.1-4.7 | .02 | ||||
| ASS | 12.9 | 6.5-25.2 | <.01 | 13.3 | 6.6-26.8 | <.01 | ||||
This group represents 76 events with acute HPV B19 and 4262 events without acute HPV B19; multivariable analysis was adjusted for age and SCD genotype.
This group represents 16 events with acute HPV B19 and 757 events without acute HPV B19; multivariable analysis was adjusted for age.
This group represents 65 events with acute HPV B19 and 3696 events without acute HPV B19; multivariable analysis was adjusted for SCD genotype and age.