DLI characteristics and outcome
Characteristic . | No. . |
|---|---|
| DLI no. 1 | 53 |
| Median cell dose | 1 × 107 CD3+ cells/kg |
| Median time from HCT, d (range) | 99 (48-1228) |
| DLI no. 2 | 17 |
| Median cell dose | 3.2 × 107 CD3+ cells/kg |
| Time from HCT, d (range) | 158 (64-692) |
| DLI no. 3 | 3 |
| Median cell dose | 3 × 108 CD3+ cells/kg |
| Time from HCT, d (range) | 237 (174-393) |
| Indication for DLI, no. patients | |
| Relapse | 17 |
| Progressive disease | 12 |
| Persistent disease | 8 |
| Low or falling chimerism/disease* | 11 |
| Low or falling chimerism | 5 |
| Response if DLI for disease*, no. patients (%) | 12/48 (25) |
| CR | 7 |
| PR | 5 |
| Chimerism response if DLI for disease; n = 28† | |
| Complete chimerism (≥ 95% donor cells) | 19 |
| Stable mixed chimerism (5%-94% donor cells) | 6 |
| Graft rejection/loss (≤ 5% donor cells) | 3 |
| Chimerism response if DLI for low or falling chimerism; n = 16 | |
| Complete chimerism (≥ 95% donor cells) | 3 |
| Stable mixed chimerism (5%-94% donor cells) | 4 |
| Graft rejection/loss (≤ 5% donor cells) | 9 |
| No. patients alive/dead | 17/36 |
| Causes of death, no. patients | |
| Disease progression/relapse | 32 |
| GVHD related | 3 |
| Infection | 1 |
Characteristic . | No. . |
|---|---|
| DLI no. 1 | 53 |
| Median cell dose | 1 × 107 CD3+ cells/kg |
| Median time from HCT, d (range) | 99 (48-1228) |
| DLI no. 2 | 17 |
| Median cell dose | 3.2 × 107 CD3+ cells/kg |
| Time from HCT, d (range) | 158 (64-692) |
| DLI no. 3 | 3 |
| Median cell dose | 3 × 108 CD3+ cells/kg |
| Time from HCT, d (range) | 237 (174-393) |
| Indication for DLI, no. patients | |
| Relapse | 17 |
| Progressive disease | 12 |
| Persistent disease | 8 |
| Low or falling chimerism/disease* | 11 |
| Low or falling chimerism | 5 |
| Response if DLI for disease*, no. patients (%) | 12/48 (25) |
| CR | 7 |
| PR | 5 |
| Chimerism response if DLI for disease; n = 28† | |
| Complete chimerism (≥ 95% donor cells) | 19 |
| Stable mixed chimerism (5%-94% donor cells) | 6 |
| Graft rejection/loss (≤ 5% donor cells) | 3 |
| Chimerism response if DLI for low or falling chimerism; n = 16 | |
| Complete chimerism (≥ 95% donor cells) | 3 |
| Stable mixed chimerism (5%-94% donor cells) | 4 |
| Graft rejection/loss (≤ 5% donor cells) | 9 |
| No. patients alive/dead | 17/36 |
| Causes of death, no. patients | |
| Disease progression/relapse | 32 |
| GVHD related | 3 |
| Infection | 1 |