Table 3. Transplantation characteristics... | American Society of Hematology

Table 3.

Transplantation characteristics of European patients undergoing hematopoietic stem cell transplantation for CD40 ligand deficiency; survivors

Case	Age at Tx, y	Donor	T-cell depletion	Conditioning	GvHD	Follow-up, y
2	1.2	MSD	Nil	bu/thio/flu/cy	Nil	2
3	2	MUD	CD34⁺	bu/cy/ATG	Nil	2.8
4	2	MUD	Nil	bu/cy/ATG	1 S	3.3
5	3	MUD	Campath	bu/cy/LFA-1/CD2	Nil	5.8
6	3.5	MSD	Nil	bu/cy	Nil	9.3
7	3.75	MUD	CD34⁺	bu/cy/ATG	2 S, L	3.3
8	4	MUD	CD34⁺	flu/mel/C1H	Nil	1.2
9	4	MUD⁺	CD34⁺	bu/cy/ATG	2 S	2
10	4	MSD	Nil	bu/cy	Nil	4
12	4.5	MUD	CD34⁺	bu/cy/ATG	Nil	3.3
13	4.5	MUD	Nil	bu/cy/ATG	2 S	3.8
14	4.5	MSD	Nil	bu/cy	Nil	3.5
16	7	MUD⁺	CD34⁺	bu/cy/ATG	Nil	4
17	7.3	MSD	Nil	bu/cy	Nil	1.6
18	8	MRD	CD34⁺	bu/cy/ATG	Nil	2
19	8	MUD	Nil	bu/cy/ATG	Nil	2.6
20	8.7	MSD	Nil	bu/cy	2 G	1.6
21	9.5	MSD	Nil	bu/cy	Nil	AR, 5.4
22	9.5	MSD	Nil	bu/cy	1 S	5
23	10	MSD	Nil	bu/cy	Nil	6.5
25	11	MUD	Nil	bu/cy/LFA-1/CD2	Nil	AR, 6.3
26	11.5	MUD	Nil	flu/mel/ATG	1 S	4.5
31	14	MRD	Nil	TBI/flu/ATG	2 S	2.5
33	15	MUD	Nil	flu/mel/C1H	2 S, L	3
34	15.7	MUD⁺	Nil	flu/mel/ATG	1 S, L	AR, 1.7
37	18	MUD	Nil	flu/mel/ATG	2 L	4.5

Case	Age at Tx, y	Donor	T-cell depletion	Conditioning	GvHD	Follow-up, y
2	1.2	MSD	Nil	bu/thio/flu/cy	Nil	2
3	2	MUD	CD34⁺	bu/cy/ATG	Nil	2.8
4	2	MUD	Nil	bu/cy/ATG	1 S	3.3
5	3	MUD	Campath	bu/cy/LFA-1/CD2	Nil	5.8
6	3.5	MSD	Nil	bu/cy	Nil	9.3
7	3.75	MUD	CD34⁺	bu/cy/ATG	2 S, L	3.3
8	4	MUD	CD34⁺	flu/mel/C1H	Nil	1.2
9	4	MUD⁺	CD34⁺	bu/cy/ATG	2 S	2
10	4	MSD	Nil	bu/cy	Nil	4
12	4.5	MUD	CD34⁺	bu/cy/ATG	Nil	3.3
13	4.5	MUD	Nil	bu/cy/ATG	2 S	3.8
14	4.5	MSD	Nil	bu/cy	Nil	3.5
16	7	MUD⁺	CD34⁺	bu/cy/ATG	Nil	4
17	7.3	MSD	Nil	bu/cy	Nil	1.6
18	8	MRD	CD34⁺	bu/cy/ATG	Nil	2
19	8	MUD	Nil	bu/cy/ATG	Nil	2.6
20	8.7	MSD	Nil	bu/cy	2 G	1.6
21	9.5	MSD	Nil	bu/cy	Nil	AR, 5.4
22	9.5	MSD	Nil	bu/cy	1 S	5
23	10	MSD	Nil	bu/cy	Nil	6.5
25	11	MUD	Nil	bu/cy/LFA-1/CD2	Nil	AR, 6.3
26	11.5	MUD	Nil	flu/mel/ATG	1 S	4.5
31	14	MRD	Nil	TBI/flu/ATG	2 S	2.5
33	15	MUD	Nil	flu/mel/C1H	2 S, L	3
34	15.7	MUD⁺	Nil	flu/mel/ATG	1 S, L	AR, 1.7
37	18	MUD	Nil	flu/mel/ATG	2 L	4.5

GvHD indicates graft versus host disease grades 1 to 4; MSD, matched sibling donor; bu, busulphan; thio, thiotepa; flu, fludarabine; cy, cyclophosphamide; MUD, matched unrelated donor 10 of 10; CD34⁺, CD34⁺ stem cell selection; ATG, rabbit antithymocyte globulin; Campath, CAMPATH-1M; S, skin; LFA-1, anti-LFA-1 antibody; CD2, anti-CD2 antibody; L, liver; mel, melphalan; C1H, alemtuzumab; MUD⁺, matched unrelated donor 9 of 10; MRD, phenotypically matched related donor; G, gut; AR, autologous reconstitution patient failed to engraft and remains well on IVIG; and TBI, total body irradiation.

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