Frequency distribution of OPN haplotypes and genotypes in 26 DALD patients and 158 controls
. | DALD . | . | Controls . | . | Statistic . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Haplotype/genotype* . | N† . | % . | N . | % . | P‡ . | OR . | 95% CI . | ||||
| A | 25 | 48 | 222 | 70 | .0027 | 0.39 | 0.21-0.74 | ||||
| B | 7 | 13.5 | 17 | 5 | .0595 | 2.74 | 0.90-7.40 | ||||
| C | 20 | 39.5 | 77 | 23 | .0491 | 1.94 | 0.99-3.73 | ||||
| AA | 3 | 11.5 | 80 | 51 | .0005 | 0.13 | 0.02-0.45 | ||||
| AB | 6 | 23 | 14 | 9 | NS | — | — | ||||
| AC | 13 | 50 | 48 | 30 | NS | — | — | ||||
| BC | 1 | 4 | 3 | 2 | NS | — | — | ||||
| CC | 3 | 11.5 | 13 | 8 | NS | — | — | ||||
. | DALD . | . | Controls . | . | Statistic . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Haplotype/genotype* . | N† . | % . | N . | % . | P‡ . | OR . | 95% CI . | ||||
| A | 25 | 48 | 222 | 70 | .0027 | 0.39 | 0.21-0.74 | ||||
| B | 7 | 13.5 | 17 | 5 | .0595 | 2.74 | 0.90-7.40 | ||||
| C | 20 | 39.5 | 77 | 23 | .0491 | 1.94 | 0.99-3.73 | ||||
| AA | 3 | 11.5 | 80 | 51 | .0005 | 0.13 | 0.02-0.45 | ||||
| AB | 6 | 23 | 14 | 9 | NS | — | — | ||||
| AC | 13 | 50 | 48 | 30 | NS | — | — | ||||
| BC | 1 | 4 | 3 | 2 | NS | — | — | ||||
| CC | 3 | 11.5 | 13 | 8 | NS | — | — | ||||
— indicates not evaluated; and NS, not significant.
Haplotype A (282T-750C-1083A-1239A), haplotype B (282C-750T-1083A-1239C), haplotype C (282C-750T-1083G-1239C); genotypes AA, AB, AC, BC, and CC; no subjects with the genotype BB were detected.
Number of chromosomes (for haplotypes) or number of subjects (for genotypes).
The haplotype overall P value = .0039; genotype overall P value = .0047.