Detection of transcripts correlating directly (profiles 1 and 2) and inversely (profile 3) with increased levels of serum IL-5
Direct correlation . | . | . | Indirect correlation . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Accession no. . | Name . | Fold . | Accession no. . | Name . | Fold . | |||||
| Eosinophil-granulocyte—inflammation associated | ||||||||||
| AI326147* | MBP-2 | 40 | Y18101 | Macrophage actin-associated protein | -6.9 | |||||
| D78353 | EPO | 26 | U43384 | gp91 phox | -5.1 | |||||
| L34570 | Arachidonate 15-lipoxygenase | 18 | X66084 | CD44 | -4.1 | |||||
| L46768 | MBP-1 | 11 | AB002663 | gp47 phox | -3.8 | |||||
| U72032 | mEar-1 | 9.4 | M60778 | LFA-1 | -2.2 | |||||
| X16490 | Plasminogen activator inhibitor 2 | 7.6 | ||||||||
| AF017258 | mEar-2 | 6.7 | ||||||||
| U12884 | VCAM-1 | 2.4 | ||||||||
| D16432 | CD63 | 2.2 | ||||||||
| X94353 | Cathelicidin | 2.2 | ||||||||
| Lymphocyte-related genes | ||||||||||
| D86232 | Lymphocyte antigen 6 complex | 2.4 | AF101164 | CEA-related CAM 2 | -18 | |||||
| M21332 | MHC class III RD gene | 2.0 | X88902 | Immunoglobulin heavy chain 4 | -10 | |||||
| L33954 | Ig variable heavy chain precursor | -8.2 | ||||||||
| L28060 | B-cell antigen receptor | -5.0 | ||||||||
| L43568 | B-cell receptor gene | -4.3 | ||||||||
| M23158 | Ly-5 | -3.1 | ||||||||
| D37797 | Lymphocyte antigen 78 | -2.6 | ||||||||
| X07640 | Mac-1 | -2.2 | ||||||||
| Nuclear and nucleolar proteins | ||||||||||
| AV306387* | Squamous cell carcinoma antigen | 2.9 | X04435 | Nuclear receptor subfamily 3 | -13.7 | |||||
| AI838366* | Brd4 | 2.6 | A1325802*† | NLVP.1 homolog | -5.3 | |||||
| AW121424*† | DNA-directed RNA pol II | 2.4 | U39074 | Thymopoietin | -3.9 | |||||
| U31758 | Histone deacetylase 2 | 2.4 | AB009275 | Major nuclear matrix protein | -3.4 | |||||
| AI854006* | SET | 2.3 | AW045530* | Inner centromere protein | -2.9 | |||||
| AV252495* | Smarcd 2 | 2.3 | AB026432 | Damage-specific DNA bind protein 1 | -2.0 | |||||
| AW120628*† | Nuclear LIM interacting factor | 2.3 | ||||||||
| M96823 | Nucleobindin | 2.0 | ||||||||
| AI849356* | Chromobox homolog 3 | 2.0 | ||||||||
| Receptors/signal transduction/cell cycle | ||||||||||
| AI563854* | TROP 2 | 3.5 | U87868‡ | Phospholipase D1b (mPLD1b) | -34/-2.1 | |||||
| AF059583 | Dok-R | 2.8 | U36776 | Syk, tyrosine kinase | -27 | |||||
| U69491 | IL-11 receptor α | 2.8 | M60909 | Retinoic receptor α | -14 | |||||
| X64534 | IL-3 receptor α | 2.4 | X83106 | MAD | -5.1 | |||||
| AW045910*† | HPK/CGK kinase | 2.2 | U29056 | Src-like adapter | -4.6 | |||||
| M80739 | Cytoplasmic protein tyrosine phosphate | 2.0 | D49393 | Protein tyrosine phosphatase | -4.3 | |||||
| AW122170* | Raf-1 | 2.0 | U21110 | STAT 5B | -3.5 | |||||
| U50413 | PI3K, regulatory subunit | -3.5 | ||||||||
| AF073997 | Myotubularin-related protein 1 | -3.5 | ||||||||
| AI747899* | Phosphatidylinositol transfer protein | -3.5 | ||||||||
| U86587 | PI3K, delta polypeptide | -3.3 | ||||||||
| AF054819 | NKG2D | -3.3 | ||||||||
| X76850 | MAPKAP kinase2 | -3.0 | ||||||||
| X62646 | IL-6 signal transducer | -2.8 | ||||||||
| L31532 | Bcl-2 | -2.7 | ||||||||
| AF005423 | CDC-like kinase 4 | -2.4 | ||||||||
| AF035646 | RAB 10 | -2.3 | ||||||||
| AB005664 | MAPK9 | -2.2 | ||||||||
| Vesicular transport/Golgi/endosome | ||||||||||
| D29797§ | Syntaxin 3 | 7.8 | AF011379 | ADAM 10 | -23 | |||||
| AJ222586 | NEFA protein | 3.3 | X54424 | Adaptor protein complex AP-1 | -12 | |||||
| AI425990* | Contain RabGAP/TBC domain | 2.9 | AW227650*† | Translocon-associated protein γ | -8.1 | |||||
| AW121185* | Dynein, heavy chain 1 | 2.8 | AB015790 | Sortilin-related receptor | -2.7 | |||||
| AI849207* | Golgi reassembly stacking protein 2 | 2.6 | AA763937* | Translocating chain ass membrane protein | -2.6 | |||||
| U06119 | Cathepsin H | 2.5 | AW259199* | Sorting nexin 2 | -2.5 | |||||
| AF085809 | Synapsin 1 | 2.3 | U52461 | Lysosomal trafficking regulator | -2.1 | |||||
| AI846182* | Huntington interacting protein 1 | 2.3 | D50032 | Trans Golgi network protein 2 | -2.0 | |||||
| W65964 | VAMP-8 | 2.2 | ||||||||
| AW125311* | ARF binding protein 1 | 2.0 | ||||||||
| AV347947*† | Ankyrin repeat/SOCS box protein | 2.0 | ||||||||
| Transcription and proliferation factors | ||||||||||
| AI854029* | PERP, p53 apoptosis effector | 6.5 | AF020772 | Karyopherin (importin) alpha 3 | -29 | |||||
| AV055186* | Ribosomal protein, large P1 | 4.0 | Y12783 | Ring finger protein 1B | -20 | |||||
| D63707 | Hepatoma-derived growth factor | 3.1 | L03547 | IKAROS | -10 | |||||
| AW208513* | TSSC6 | 2.3 | AV380793*† | Eukaryotic initiation factor 4G | -7.5 | |||||
| M36146 | Zfp-35 | 2.3 | X66091 | Alternate splicing factor | -6.4 | |||||
| U93862 | Ribosomal protein L41 | 2.1 | X53250 | Zfa gene | -6.0 | |||||
| X15962 | Ribosomal protein S12 | 2.1 | AA674798*† | TATA-BP-interacting protein | -5.3 | |||||
| AV105022* | Ribosomal protein 10 | 2.1 | AI131735* | Poly A polymerase α | -4.9 | |||||
| AI836082* | TF IIIC 1 | 2.1 | AF099974 | Schlafen 3 | -3.9 | |||||
| L21973 | E2F transcription factor 1 | 2.1 | U80821 | C1 transcription factor gene | -3.6 | |||||
| AI844751*† | Eukaryotic translation terminal factor 1 | 2.1 | AF043939 | DP-1 | -3.4 | |||||
| X57687 | Lyl | 2.0 | Y15907 | Myc-intron binding protein 1 | -3.1 | |||||
| U35141 | Retinoblastoma binding protein 4 | 2.0 | U21855 | CCR4-NOT transcription complex | -3.1 | |||||
| M57999 | NF kappa B | 2.0 | AF037206 | Ring finger protein 13 | -3.0 | |||||
| AB000096¶ | GATA-2 | 1.6 | AF077658 | Homeodomain interact protein kinase | -2.9 | |||||
| X15763¶ | GATA-1 | 1.5 | AF084480 | Bromodomain adj zing finger domain | -2.8 | |||||
| U97572 | Excision repair cross-complementary | -2.8 | ||||||||
| D86527 | Werner syndrome homolog | -2.7 | ||||||||
| AI844532*† | Similar to splicing factor 3b | -2.5 | ||||||||
| AF061270 | Pbx/knotted 1 homeobox | -2.4 | ||||||||
| AW209414* | Zfp422 | -2.4 | ||||||||
| M13945 | Pim-1 | -2.2 | ||||||||
| U67321 | Caspase 7 | -2.3 | ||||||||
| U10325 | Aryl hydrocarbon rec nucl transloc | -2.3 | ||||||||
| Y11245 | Forkhead box M1 | -2.1 | ||||||||
| U09928 | Eukaryot TIF 2-alpha kinase | -2.1 | ||||||||
| AF052506 | Adenosine deaminase, RNA spec | -2.0 | ||||||||
| AF026524 | Inhibitor of kappa B kinase β | -2.0 | ||||||||
Direct correlation . | . | . | Indirect correlation . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Accession no. . | Name . | Fold . | Accession no. . | Name . | Fold . | |||||
| Eosinophil-granulocyte—inflammation associated | ||||||||||
| AI326147* | MBP-2 | 40 | Y18101 | Macrophage actin-associated protein | -6.9 | |||||
| D78353 | EPO | 26 | U43384 | gp91 phox | -5.1 | |||||
| L34570 | Arachidonate 15-lipoxygenase | 18 | X66084 | CD44 | -4.1 | |||||
| L46768 | MBP-1 | 11 | AB002663 | gp47 phox | -3.8 | |||||
| U72032 | mEar-1 | 9.4 | M60778 | LFA-1 | -2.2 | |||||
| X16490 | Plasminogen activator inhibitor 2 | 7.6 | ||||||||
| AF017258 | mEar-2 | 6.7 | ||||||||
| U12884 | VCAM-1 | 2.4 | ||||||||
| D16432 | CD63 | 2.2 | ||||||||
| X94353 | Cathelicidin | 2.2 | ||||||||
| Lymphocyte-related genes | ||||||||||
| D86232 | Lymphocyte antigen 6 complex | 2.4 | AF101164 | CEA-related CAM 2 | -18 | |||||
| M21332 | MHC class III RD gene | 2.0 | X88902 | Immunoglobulin heavy chain 4 | -10 | |||||
| L33954 | Ig variable heavy chain precursor | -8.2 | ||||||||
| L28060 | B-cell antigen receptor | -5.0 | ||||||||
| L43568 | B-cell receptor gene | -4.3 | ||||||||
| M23158 | Ly-5 | -3.1 | ||||||||
| D37797 | Lymphocyte antigen 78 | -2.6 | ||||||||
| X07640 | Mac-1 | -2.2 | ||||||||
| Nuclear and nucleolar proteins | ||||||||||
| AV306387* | Squamous cell carcinoma antigen | 2.9 | X04435 | Nuclear receptor subfamily 3 | -13.7 | |||||
| AI838366* | Brd4 | 2.6 | A1325802*† | NLVP.1 homolog | -5.3 | |||||
| AW121424*† | DNA-directed RNA pol II | 2.4 | U39074 | Thymopoietin | -3.9 | |||||
| U31758 | Histone deacetylase 2 | 2.4 | AB009275 | Major nuclear matrix protein | -3.4 | |||||
| AI854006* | SET | 2.3 | AW045530* | Inner centromere protein | -2.9 | |||||
| AV252495* | Smarcd 2 | 2.3 | AB026432 | Damage-specific DNA bind protein 1 | -2.0 | |||||
| AW120628*† | Nuclear LIM interacting factor | 2.3 | ||||||||
| M96823 | Nucleobindin | 2.0 | ||||||||
| AI849356* | Chromobox homolog 3 | 2.0 | ||||||||
| Receptors/signal transduction/cell cycle | ||||||||||
| AI563854* | TROP 2 | 3.5 | U87868‡ | Phospholipase D1b (mPLD1b) | -34/-2.1 | |||||
| AF059583 | Dok-R | 2.8 | U36776 | Syk, tyrosine kinase | -27 | |||||
| U69491 | IL-11 receptor α | 2.8 | M60909 | Retinoic receptor α | -14 | |||||
| X64534 | IL-3 receptor α | 2.4 | X83106 | MAD | -5.1 | |||||
| AW045910*† | HPK/CGK kinase | 2.2 | U29056 | Src-like adapter | -4.6 | |||||
| M80739 | Cytoplasmic protein tyrosine phosphate | 2.0 | D49393 | Protein tyrosine phosphatase | -4.3 | |||||
| AW122170* | Raf-1 | 2.0 | U21110 | STAT 5B | -3.5 | |||||
| U50413 | PI3K, regulatory subunit | -3.5 | ||||||||
| AF073997 | Myotubularin-related protein 1 | -3.5 | ||||||||
| AI747899* | Phosphatidylinositol transfer protein | -3.5 | ||||||||
| U86587 | PI3K, delta polypeptide | -3.3 | ||||||||
| AF054819 | NKG2D | -3.3 | ||||||||
| X76850 | MAPKAP kinase2 | -3.0 | ||||||||
| X62646 | IL-6 signal transducer | -2.8 | ||||||||
| L31532 | Bcl-2 | -2.7 | ||||||||
| AF005423 | CDC-like kinase 4 | -2.4 | ||||||||
| AF035646 | RAB 10 | -2.3 | ||||||||
| AB005664 | MAPK9 | -2.2 | ||||||||
| Vesicular transport/Golgi/endosome | ||||||||||
| D29797§ | Syntaxin 3 | 7.8 | AF011379 | ADAM 10 | -23 | |||||
| AJ222586 | NEFA protein | 3.3 | X54424 | Adaptor protein complex AP-1 | -12 | |||||
| AI425990* | Contain RabGAP/TBC domain | 2.9 | AW227650*† | Translocon-associated protein γ | -8.1 | |||||
| AW121185* | Dynein, heavy chain 1 | 2.8 | AB015790 | Sortilin-related receptor | -2.7 | |||||
| AI849207* | Golgi reassembly stacking protein 2 | 2.6 | AA763937* | Translocating chain ass membrane protein | -2.6 | |||||
| U06119 | Cathepsin H | 2.5 | AW259199* | Sorting nexin 2 | -2.5 | |||||
| AF085809 | Synapsin 1 | 2.3 | U52461 | Lysosomal trafficking regulator | -2.1 | |||||
| AI846182* | Huntington interacting protein 1 | 2.3 | D50032 | Trans Golgi network protein 2 | -2.0 | |||||
| W65964 | VAMP-8 | 2.2 | ||||||||
| AW125311* | ARF binding protein 1 | 2.0 | ||||||||
| AV347947*† | Ankyrin repeat/SOCS box protein | 2.0 | ||||||||
| Transcription and proliferation factors | ||||||||||
| AI854029* | PERP, p53 apoptosis effector | 6.5 | AF020772 | Karyopherin (importin) alpha 3 | -29 | |||||
| AV055186* | Ribosomal protein, large P1 | 4.0 | Y12783 | Ring finger protein 1B | -20 | |||||
| D63707 | Hepatoma-derived growth factor | 3.1 | L03547 | IKAROS | -10 | |||||
| AW208513* | TSSC6 | 2.3 | AV380793*† | Eukaryotic initiation factor 4G | -7.5 | |||||
| M36146 | Zfp-35 | 2.3 | X66091 | Alternate splicing factor | -6.4 | |||||
| U93862 | Ribosomal protein L41 | 2.1 | X53250 | Zfa gene | -6.0 | |||||
| X15962 | Ribosomal protein S12 | 2.1 | AA674798*† | TATA-BP-interacting protein | -5.3 | |||||
| AV105022* | Ribosomal protein 10 | 2.1 | AI131735* | Poly A polymerase α | -4.9 | |||||
| AI836082* | TF IIIC 1 | 2.1 | AF099974 | Schlafen 3 | -3.9 | |||||
| L21973 | E2F transcription factor 1 | 2.1 | U80821 | C1 transcription factor gene | -3.6 | |||||
| AI844751*† | Eukaryotic translation terminal factor 1 | 2.1 | AF043939 | DP-1 | -3.4 | |||||
| X57687 | Lyl | 2.0 | Y15907 | Myc-intron binding protein 1 | -3.1 | |||||
| U35141 | Retinoblastoma binding protein 4 | 2.0 | U21855 | CCR4-NOT transcription complex | -3.1 | |||||
| M57999 | NF kappa B | 2.0 | AF037206 | Ring finger protein 13 | -3.0 | |||||
| AB000096¶ | GATA-2 | 1.6 | AF077658 | Homeodomain interact protein kinase | -2.9 | |||||
| X15763¶ | GATA-1 | 1.5 | AF084480 | Bromodomain adj zing finger domain | -2.8 | |||||
| U97572 | Excision repair cross-complementary | -2.8 | ||||||||
| D86527 | Werner syndrome homolog | -2.7 | ||||||||
| AI844532*† | Similar to splicing factor 3b | -2.5 | ||||||||
| AF061270 | Pbx/knotted 1 homeobox | -2.4 | ||||||||
| AW209414* | Zfp422 | -2.4 | ||||||||
| M13945 | Pim-1 | -2.2 | ||||||||
| U67321 | Caspase 7 | -2.3 | ||||||||
| U10325 | Aryl hydrocarbon rec nucl transloc | -2.3 | ||||||||
| Y11245 | Forkhead box M1 | -2.1 | ||||||||
| U09928 | Eukaryot TIF 2-alpha kinase | -2.1 | ||||||||
| AF052506 | Adenosine deaminase, RNA spec | -2.0 | ||||||||
| AF026524 | Inhibitor of kappa B kinase β | -2.0 | ||||||||
See Figure 3 and text for profile descriptions.
LFA-1 indicates lymphocyte function antigen-1; VCAM-1, vascular cell adhesion molecule-1; CEA, carcinoembryonic antigen; CAM 2, cellular adhesion molecule 2; MHC, major histocompatibility complex; Ig, immunoglobulin; SET, leukemia-associated protein; TROP 2, tropisetron 2; Dok-R, downstream-of-kinase—related; MAD, myoadenylate deaminase; HPK/CGK, histidine protein kinase/complex glycerol kinase; STAT 5B, signal transducer and activator of transcription 5B; PI3K, phosphatidyl inositol-3 kinase; NKG2D, natural killer—activating receptor G2D; MAPKAP, mitogen-activated protein kinase-activated protein; CDC, complement-dependent cytotoxicity; RAB 10, rac-activating and binding protein 10; MAPK9 mitogen-activated protein kinase 9; ADAM 10, adamalysin family protein 10; NEFA, nonesterified fatty acid; VAMP-8, vesicle-associated membrane protein 8; SOCS, suppressor of cytokine signaling family of proteins; TSSC6, tetraspanin 6; TATA-BP, tumor-associated transplantation antigen basic protein; TF, tissue factor; DP-1, differentiation polypeptide-1; CCR4-NOT, regulator of gene transcription in yeast; NF, nuclear factor; TIF 2-alpha, tumor-inhibiting factor 2-alpha.
EST sequence, identity identified by BLAST search.
Identified by homology to genes in Homo sapiens or Rattus norvegicus.
Duplicate readouts with significant divergence.
Profile 2.
Not ≥2.0-fold increase, included for specific interest related to eosinophilopoiesis.