Table 5.

Disease responses

Patient no.
Donor
Indication
Best response
GVHD
Maximum DLI dose, T cells/kg
Most recent response
Status*
1   Sib   MM residual disease   CR   Yes   1 × 107  Relapse   A  
2   MUD   MM residual disease   PR   Yes   3 × 107  PR   A  
3   MUD   MM residual disease   PR   Yes   3 × 107  PR   A  
4   MUD   MM residual disease   PR   Yes   1 × 106  PR   D-GVHD  
5   MUD   MM residual disease   PR   No   1 × 108  Progression   D-dis  
6   Sib   MM residual disease   MR   No   1 × 107  Progression   D-dis  
7   Sib   MM residual disease   NC   No   1 × 106  NC   A  
8   MUD   MM residual disease   NC†  Yes   3 × 106  Progression   A  
9   Sib   MM residual disease   NC   No   1 × 108  Progression   A  
10   Sib   MM residual disease   NC   No   3 × 106  Progression   A  
11   Sib   MM residual disease   NC   Yes   1 × 107  Progression   D-PTLD  
12   MUD   MM progression   PR   Yes   1 × 107  Progression   D-GVH/dis  
13   MUD   MM progression   PR   Yes   3 × 106  Progression   D-GVH/dis  
14   Sib   MM progression   PR†  Yes   1 × 107  Progression   D-GVH/dis  
15   Sib   MM progression   PR   No   3 × 108  Progression   A  
16   Sib   MM progression   NC   No   1 × 108  NC   A  
17   Sib   MM progression   NC   No   1 × 108  Progression   A  
18   Sib   MM progression   NR   No   3 × 107  Progression   D-dis  
19   Sib   MM progression   NR   No   3 × 106  Progression   D-dis  
20   MUD   HL residual disease   NR   No   1 × 106  Progression   A  
21   MUD   HL progression   CR   Yes   1 × 107  CR   A  
22   Sib   HL progression   CR   No   1 × 107  CR   A  
23   Sib   HL progression   CR†  Yes   1 × 108  Relapse   A  
24   Sib   HL progression   CR†  Yes   1 × 108  CR   D-GVH  
25   Sib   HL progression   CR   Yes   1 × 107  CR   D-PTLD  
26   Sib   HL progression   PR   No   1 × 108  PR   A  
27   Sib   HL progression   PR   No   3 × 108  Progression   A  
28   Sib   HL progression   NR   No   1 × 108  Progression   A  
29   Sib   MC progression   NR†  Yes   3 × 107  Progression   D-dis  
30   Sib   LG-NHL residual disease   PR†  No   1 × 108  PR   A  
31   Sib   LG-NHL MC progression   CR   No   3 × 107  CR   A  
32   Sib   LG-NHL MC progression   NE   No   3 × 107  Progression   A  
33   Sib   CLL MC-MRD   CR   Yes   3 × 107  CR   A  
34   Sib   HG-NHL progression   NE   No   1 × 107  CR   A  
35   MUD   PLL progression   NR†  No   1 × 107  Progression   D-dis  
36
 		 Sib
 		 CML progression
 		 Cyt CR
 		 No
 		 3 × 106
 		 Cyt CR
 		 A
 
Patient no.
Donor
Indication
Best response
GVHD
Maximum DLI dose, T cells/kg
Most recent response
Status*
1   Sib   MM residual disease   CR   Yes   1 × 107  Relapse   A  
2   MUD   MM residual disease   PR   Yes   3 × 107  PR   A  
3   MUD   MM residual disease   PR   Yes   3 × 107  PR   A  
4   MUD   MM residual disease   PR   Yes   1 × 106  PR   D-GVHD  
5   MUD   MM residual disease   PR   No   1 × 108  Progression   D-dis  
6   Sib   MM residual disease   MR   No   1 × 107  Progression   D-dis  
7   Sib   MM residual disease   NC   No   1 × 106  NC   A  
8   MUD   MM residual disease   NC†  Yes   3 × 106  Progression   A  
9   Sib   MM residual disease   NC   No   1 × 108  Progression   A  
10   Sib   MM residual disease   NC   No   3 × 106  Progression   A  
11   Sib   MM residual disease   NC   Yes   1 × 107  Progression   D-PTLD  
12   MUD   MM progression   PR   Yes   1 × 107  Progression   D-GVH/dis  
13   MUD   MM progression   PR   Yes   3 × 106  Progression   D-GVH/dis  
14   Sib   MM progression   PR†  Yes   1 × 107  Progression   D-GVH/dis  
15   Sib   MM progression   PR   No   3 × 108  Progression   A  
16   Sib   MM progression   NC   No   1 × 108  NC   A  
17   Sib   MM progression   NC   No   1 × 108  Progression   A  
18   Sib   MM progression   NR   No   3 × 107  Progression   D-dis  
19   Sib   MM progression   NR   No   3 × 106  Progression   D-dis  
20   MUD   HL residual disease   NR   No   1 × 106  Progression   A  
21   MUD   HL progression   CR   Yes   1 × 107  CR   A  
22   Sib   HL progression   CR   No   1 × 107  CR   A  
23   Sib   HL progression   CR†  Yes   1 × 108  Relapse   A  
24   Sib   HL progression   CR†  Yes   1 × 108  CR   D-GVH  
25   Sib   HL progression   CR   Yes   1 × 107  CR   D-PTLD  
26   Sib   HL progression   PR   No   1 × 108  PR   A  
27   Sib   HL progression   PR   No   3 × 108  Progression   A  
28   Sib   HL progression   NR   No   1 × 108  Progression   A  
29   Sib   MC progression   NR†  Yes   3 × 107  Progression   D-dis  
30   Sib   LG-NHL residual disease   PR†  No   1 × 108  PR   A  
31   Sib   LG-NHL MC progression   CR   No   3 × 107  CR   A  
32   Sib   LG-NHL MC progression   NE   No   3 × 107  Progression   A  
33   Sib   CLL MC-MRD   CR   Yes   3 × 107  CR   A  
34   Sib   HG-NHL progression   NE   No   1 × 107  CR   A  
35   MUD   PLL progression   NR†  No   1 × 107  Progression   D-dis  
36
 		 Sib
 		 CML progression
 		 Cyt CR
 		 No
 		 3 × 106
 		 Cyt CR
 		 A
 

MM indicates multiple myeloma; A, alive; D, dead; dis, underlying disease; MR, minimal response; NC, no change; NR, no response; HL, Hodgkin lymphoma; NE; not evaluable; MC, mixed chimerism; MRD, minimal residual disease; Cyt CR, complete cytogenetic response. Other abbreviations are defined in the text or in Tables 1, 3, and 4.

*

Including major cause of death.

†

Patients receiving antitumoral chemotherapy prior to DLI.

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal