Selected up-regulated and down-regulated genes in patient MM cells versus normal twin PCs
Gene . | GenBank accession no. . | Fold change . |
|---|---|---|
| Cell cycle/proliferation/adhesion | ||
| MD-2 | AB018549 | 86.9 |
| RING1 | AL031228 | 70.4 |
| JUN | J04111 | 66.6 |
| PAK3 | AF068864 | 54.3 |
| FOSA | V01512 | 38.1 |
| NFKBIA | M69043 | 37.1 |
| JUND | X56681 | 32.1 |
| KPNA4 | AB002533 | 29.4 |
| RAN | AF054183 | 28.8 |
| PECAM1 | L34657 | 19.0 |
| CALM2 | M19311 | 15.2 |
| CANX | L10284 | 10.2 |
| S100A4 | W72186 | 9.4 |
| FGFR3 | M64347 | 9.0 |
| FZR1 | AA932443 | 8.0 |
| CD68 | S57235 | 7.2 |
| PIM2 | U77735 | 6.9 |
| CALR | M84739 | 6.3 |
| hTERT | AF015950 | 5.7 |
| AXL | M76125 | 5.5 |
| TRIM32 | U18543 | 5.2 |
| MSI1 | AB012851 | 5.0 |
| CD63 | X62654 | 4.7 |
| 101f6 | AF040704 | 4.5 |
| USF2 | Y07661 | 4.3 |
| VAV2 | S76992 | 4.0 |
| ARHD | AW003733 | 3.7 |
| FLT3LG | U03858 | 3.7 |
| CNNM2 | AI827730 | 3.6 |
| DDX18 | X98743 | 3.5 |
| KATNB1 | AF052432 | 3.3 |
| HCLS1 | X16663 | 3.2 |
| RELB | M83221 | 2.9 |
| WIT-1 | M60614 | 2.8 |
| SNF2-BETA | U29175 | -3.0 |
| VAMP5 | AF054825 | -3.2 |
| DKC1 | U59151 | -5.1 |
| SKII | Z19588 | -6.0 |
| NPR2 | AF040707 | -7.0 |
| RAD51 | D14134 | -25.4 |
| Apoptosis/survival/drug resistance | ||
| DAD1 | D15057 | 57.9 |
| FLIP | AF005775 | 29.9 |
| MCL1 | L08246 | 25.3 |
| XRCC5 | M30938 | 8.9 |
| CFTR/MRP3 | U83659 | 7.7 |
| GSTM4 | M96233 | 6.8 |
| ANXA2 | D00017 | 3.6 |
| KIR2DL4 | X97229 | -5.6 |
| Proteasome and ubiquitins | ||
| UBB | X04803 | 153.8 |
| UBC | M26880 | 97.1 |
| PSMA2 | D00760 | 74.5 |
| PSMB1 | D00761 | 72.2 |
| SMT3L | AL031133 | 38.7 |
| PSME2 | D45248 | 20.0 |
| UQCR | T58471 | 18.6 |
| UBE2L3 | S81003 | 7.2 |
| USP22 | AB028986 | 3.9 |
| USP9X | X98296 | 2.9 |
| UCHL1 | X04741 | -3.3 |
| Cytokine and cytokine receptors | ||
| IFITM1 | J04164 | 32.4 |
| ILF1 | U58198 | 28.8 |
| TNFR4 | Z29574 | 25.1 |
| EDF1 | AJ005259 | 14.4 |
| CXCR4 | L06797 | 13.8 |
| ISG20 | U88964 | 12.5 |
| LIFR | X61615 | 9.0 |
| FST | M19481 | 9.0 |
| ANGPT1 | D13628 | 5.8 |
| EPOR | X97671 | 5.5 |
| ACVRL1 | Z22533 | 5.0 |
| CSF2 | M13207 | 3.8 |
| CSF1 | M37435 | 3.7 |
| TGFB3B | M60556 | 3.0 |
| EPOR | AF053356 | -2.5 |
| Differentiation/translation/ER | ||
| SSR4 | Z69043 | 87.5 |
| DBI | AI557240 | 86.2 |
| NACA | AF054187 | 71.4 |
| ZNF91 | L11672 | 67.6 |
| EEF1A1 | J04617 | 29.9 |
| XBP1 | Z93930 | 26.8 |
| KRT8 | X74929 | 17.9 |
| EIF4G2 | U73824 | 5.8 |
| EVIN1 | AB002405 | 3.2 |
| CNOT2 | AI123426 | -5.0 |
| Miscellaneous | ||
| HSP70 | X87949 | 106.1 |
| GP96 | X15187 | 80.0 |
| G3PD | U34995 | 60.1 |
| PFDN5 | D89667 | 29.2 |
| FKBP2 | AA158243 | 17.8 |
| HSP10 | AI912041 | 15.2 |
| LDHB | X13794 | 13.5 |
| HAX1 | U68566 | 11.3 |
| HSF1 | M64673 | -2.9 |
Gene . | GenBank accession no. . | Fold change . |
|---|---|---|
| Cell cycle/proliferation/adhesion | ||
| MD-2 | AB018549 | 86.9 |
| RING1 | AL031228 | 70.4 |
| JUN | J04111 | 66.6 |
| PAK3 | AF068864 | 54.3 |
| FOSA | V01512 | 38.1 |
| NFKBIA | M69043 | 37.1 |
| JUND | X56681 | 32.1 |
| KPNA4 | AB002533 | 29.4 |
| RAN | AF054183 | 28.8 |
| PECAM1 | L34657 | 19.0 |
| CALM2 | M19311 | 15.2 |
| CANX | L10284 | 10.2 |
| S100A4 | W72186 | 9.4 |
| FGFR3 | M64347 | 9.0 |
| FZR1 | AA932443 | 8.0 |
| CD68 | S57235 | 7.2 |
| PIM2 | U77735 | 6.9 |
| CALR | M84739 | 6.3 |
| hTERT | AF015950 | 5.7 |
| AXL | M76125 | 5.5 |
| TRIM32 | U18543 | 5.2 |
| MSI1 | AB012851 | 5.0 |
| CD63 | X62654 | 4.7 |
| 101f6 | AF040704 | 4.5 |
| USF2 | Y07661 | 4.3 |
| VAV2 | S76992 | 4.0 |
| ARHD | AW003733 | 3.7 |
| FLT3LG | U03858 | 3.7 |
| CNNM2 | AI827730 | 3.6 |
| DDX18 | X98743 | 3.5 |
| KATNB1 | AF052432 | 3.3 |
| HCLS1 | X16663 | 3.2 |
| RELB | M83221 | 2.9 |
| WIT-1 | M60614 | 2.8 |
| SNF2-BETA | U29175 | -3.0 |
| VAMP5 | AF054825 | -3.2 |
| DKC1 | U59151 | -5.1 |
| SKII | Z19588 | -6.0 |
| NPR2 | AF040707 | -7.0 |
| RAD51 | D14134 | -25.4 |
| Apoptosis/survival/drug resistance | ||
| DAD1 | D15057 | 57.9 |
| FLIP | AF005775 | 29.9 |
| MCL1 | L08246 | 25.3 |
| XRCC5 | M30938 | 8.9 |
| CFTR/MRP3 | U83659 | 7.7 |
| GSTM4 | M96233 | 6.8 |
| ANXA2 | D00017 | 3.6 |
| KIR2DL4 | X97229 | -5.6 |
| Proteasome and ubiquitins | ||
| UBB | X04803 | 153.8 |
| UBC | M26880 | 97.1 |
| PSMA2 | D00760 | 74.5 |
| PSMB1 | D00761 | 72.2 |
| SMT3L | AL031133 | 38.7 |
| PSME2 | D45248 | 20.0 |
| UQCR | T58471 | 18.6 |
| UBE2L3 | S81003 | 7.2 |
| USP22 | AB028986 | 3.9 |
| USP9X | X98296 | 2.9 |
| UCHL1 | X04741 | -3.3 |
| Cytokine and cytokine receptors | ||
| IFITM1 | J04164 | 32.4 |
| ILF1 | U58198 | 28.8 |
| TNFR4 | Z29574 | 25.1 |
| EDF1 | AJ005259 | 14.4 |
| CXCR4 | L06797 | 13.8 |
| ISG20 | U88964 | 12.5 |
| LIFR | X61615 | 9.0 |
| FST | M19481 | 9.0 |
| ANGPT1 | D13628 | 5.8 |
| EPOR | X97671 | 5.5 |
| ACVRL1 | Z22533 | 5.0 |
| CSF2 | M13207 | 3.8 |
| CSF1 | M37435 | 3.7 |
| TGFB3B | M60556 | 3.0 |
| EPOR | AF053356 | -2.5 |
| Differentiation/translation/ER | ||
| SSR4 | Z69043 | 87.5 |
| DBI | AI557240 | 86.2 |
| NACA | AF054187 | 71.4 |
| ZNF91 | L11672 | 67.6 |
| EEF1A1 | J04617 | 29.9 |
| XBP1 | Z93930 | 26.8 |
| KRT8 | X74929 | 17.9 |
| EIF4G2 | U73824 | 5.8 |
| EVIN1 | AB002405 | 3.2 |
| CNOT2 | AI123426 | -5.0 |
| Miscellaneous | ||
| HSP70 | X87949 | 106.1 |
| GP96 | X15187 | 80.0 |
| G3PD | U34995 | 60.1 |
| PFDN5 | D89667 | 29.2 |
| FKBP2 | AA158243 | 17.8 |
| HSP10 | AI912041 | 15.2 |
| LDHB | X13794 | 13.5 |
| HAX1 | U68566 | 11.3 |
| HSF1 | M64673 | -2.9 |
List of genes selected based on their potential functional categories. Fold change shown represents the ratio of gene expression in patient MM cells versus healthy twin PCs. The gene expression values were obtained using Dchip analyzer.