Factors independently associated with overall percentage of joint range-of-motion limitation among 2- to 19-year-old males with hemophilia based on separate linear regression models for disease severity
. | Severe, n = 2282 . | . | . | Moderate, n = 1010 . | . | . | Mild, n = 895 . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Factor . | β . | SE . | P . | β . | SE . | P . | β . | SE . | P . | ||||||
| Intercept | —3.37 | 0.455 | < .001 | —2.71 | 0.418 | < .001 | —2.12 | 0.323 | < .001 | ||||||
| Age | —0.03 | 0.075 | .65 | 0.15 | 0.023 | < .001 | 0.02 | 0.018 | .2 | ||||||
| Age-squared | 0.02 | 0.003 | < .001 | — | — | — | — | — | — | ||||||
| Nonwhite race | 0.88 | 0.170 | < .001 | — | — | — | — | — | — | ||||||
| Body mass index | 0.13 | 0.018 | < .001 | 0.08 | 0.022 | < .001 | 0.09 | 0.018 | < .001 | ||||||
| Inhibitor | 1.71 | 0.317 | < .001 | — | — | — | — | — | — | ||||||
| Number of bleeds | 0.04 | 0.006 | < .001 | — | — | — | — | — | — | ||||||
| Orthopedic procedure | 0.99 | 0.416 | .02 | — | — | — | — | — | — | ||||||
| Infrequent HTC use | — | — | — | —0.66 | 0.294 | .02 | —0.42 | 0.169 | .01 | ||||||
| Hemophilia A (vs B) | — | — | — | 0.50 | 0.208 | .02 | — | — | — | ||||||
. | Severe, n = 2282 . | . | . | Moderate, n = 1010 . | . | . | Mild, n = 895 . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Factor . | β . | SE . | P . | β . | SE . | P . | β . | SE . | P . | ||||||
| Intercept | —3.37 | 0.455 | < .001 | —2.71 | 0.418 | < .001 | —2.12 | 0.323 | < .001 | ||||||
| Age | —0.03 | 0.075 | .65 | 0.15 | 0.023 | < .001 | 0.02 | 0.018 | .2 | ||||||
| Age-squared | 0.02 | 0.003 | < .001 | — | — | — | — | — | — | ||||||
| Nonwhite race | 0.88 | 0.170 | < .001 | — | — | — | — | — | — | ||||||
| Body mass index | 0.13 | 0.018 | < .001 | 0.08 | 0.022 | < .001 | 0.09 | 0.018 | < .001 | ||||||
| Inhibitor | 1.71 | 0.317 | < .001 | — | — | — | — | — | — | ||||||
| Number of bleeds | 0.04 | 0.006 | < .001 | — | — | — | — | — | — | ||||||
| Orthopedic procedure | 0.99 | 0.416 | .02 | — | — | — | — | — | — | ||||||
| Infrequent HTC use | — | — | — | —0.66 | 0.294 | .02 | —0.42 | 0.169 | .01 | ||||||
| Hemophilia A (vs B) | — | — | — | 0.50 | 0.208 | .02 | — | — | — | ||||||
Total numbers of persons with complete data for all variables and included in each regression analysis.
β indicates parameter estimate; SE, standard error; and HTC, hemophilia treatment center. — indicates factor not included in the regression model.