Table 1.

Hemostatic indices for patients II.1 and II.2




Patient
Test
Normal range
II.1
II.2
Fibrinogen (clottable), mg/mL   1.5-3.5   0.3   0.3  
Fibrinogen (total), mg/mL   1.5-3.5   ND   0.5  
APTT, sec   22-30   30   34  
PT, sec   11-13   22   21  
TT, sec   16-18   46   52  
Whole blood clotting time, min   3-8   15   10  
Plasma clot lysis time, min   27   101   104  
Compressed clot, mm   0.8-1.0*  ND   1.6  
t-PA, ng/mL   4-6   6   12  
PAI-1, ng/mL   8-28   18   48  
Platelet count/μL, × 10-3  150-400   218   242  
FVIII, %   55-183   197   178  
FIX, %   50-150   70   95  
FXI, %
 
56-164
 
92
 
100
 



Patient
Test
Normal range
II.1
II.2
Fibrinogen (clottable), mg/mL   1.5-3.5   0.3   0.3  
Fibrinogen (total), mg/mL   1.5-3.5   ND   0.5  
APTT, sec   22-30   30   34  
PT, sec   11-13   22   21  
TT, sec   16-18   46   52  
Whole blood clotting time, min   3-8   15   10  
Plasma clot lysis time, min   27   101   104  
Compressed clot, mm   0.8-1.0*  ND   1.6  
t-PA, ng/mL   4-6   6   12  
PAI-1, ng/mL   8-28   18   48  
Platelet count/μL, × 10-3  150-400   218   242  
FVIII, %   55-183   197   178  
FIX, %   50-150   70   95  
FXI, %
 
56-164
 
92
 
100
 
*

Normal plasma (fibrinogen = 2-3 mg/mL). Clots from normal plasma, diluted to 0.3 mg/mL with defibrinogenated plasma, were compressed to 0.007 mm. ND indicates not determined

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