Distribution of the subtype-discriminating genes within specific clusters
Gene-expression variable . | No. of microarray features in signature n = 2532 . | No. of microarray features significantly associated (P < .00001) with diagnosis of SLL n = 178 . | No. of microarray features significantly associated (P < .00001) with diagnosis of MZL n = 83 . | No. of microarray features significantly associated (P < .00001) with diagnosis of MCL n = 154 . | Representative genes . | GenBank accession no. . |
|---|---|---|---|---|---|---|
| SLL cluster | 735 | 163 | 1 | 12 | L-selectin | AJ246000 |
| IL4-R | C75499 | |||||
| TNF-R17 | ||||||
| Cyclin D1 cluster | 13 | 0 | 0 | 13 | CCND1 | NM 053056 |
| MCL cluster | 349 | 1 | 1 | 75 | PCNA | AF508260 |
| CDK4 | NM_007671 | |||||
| MYBL2 | ||||||
| Early response cluster | 20 | 0 | 0 | 0 | Fos | V01512 |
| Spleen cluster | 54 | 0 | 36 | 0 | HBZ | J00182 |
| KLF1 | NM_006563 | |||||
| EPB41L2 | M_001431 | |||||
| MZL cluster | 17 | 0 | 11 | 0 | AKT1 | AF283829 |
| AGER | NM_173982 | |||||
| MXI1 | BC012907 | |||||
| T-cells cluster | 15 | 0 | 4 | 0 | CD3A | — |
| CD3G | X06026 | |||||
| Stroma cluster | 38 | 0 | 3 | 5 | SPARC | J03040 |
| MMP9 | J05079 | |||||
| Others | 1291 | 14 | 27 | 49 | — |
Gene-expression variable . | No. of microarray features in signature n = 2532 . | No. of microarray features significantly associated (P < .00001) with diagnosis of SLL n = 178 . | No. of microarray features significantly associated (P < .00001) with diagnosis of MZL n = 83 . | No. of microarray features significantly associated (P < .00001) with diagnosis of MCL n = 154 . | Representative genes . | GenBank accession no. . |
|---|---|---|---|---|---|---|
| SLL cluster | 735 | 163 | 1 | 12 | L-selectin | AJ246000 |
| IL4-R | C75499 | |||||
| TNF-R17 | ||||||
| Cyclin D1 cluster | 13 | 0 | 0 | 13 | CCND1 | NM 053056 |
| MCL cluster | 349 | 1 | 1 | 75 | PCNA | AF508260 |
| CDK4 | NM_007671 | |||||
| MYBL2 | ||||||
| Early response cluster | 20 | 0 | 0 | 0 | Fos | V01512 |
| Spleen cluster | 54 | 0 | 36 | 0 | HBZ | J00182 |
| KLF1 | NM_006563 | |||||
| EPB41L2 | M_001431 | |||||
| MZL cluster | 17 | 0 | 11 | 0 | AKT1 | AF283829 |
| AGER | NM_173982 | |||||
| MXI1 | BC012907 | |||||
| T-cells cluster | 15 | 0 | 4 | 0 | CD3A | — |
| CD3G | X06026 | |||||
| Stroma cluster | 38 | 0 | 3 | 5 | SPARC | J03040 |
| MMP9 | J05079 | |||||
| Others | 1291 | 14 | 27 | 49 | — |
—indicates no unique accession number.