Table 2.

Effect of platelet inhibitors on LPA-induced platelet aggregation of washed platelets



Aggregation, % light transmission

Control
Aspirin
LPA, 30 μM   80 ± 5   73 ± 16  
AR-C69931MX + LPA   36 ± 16  33 ± 14* 
MRS2179 + LPA   41 ± 24*  32 ± 19* 
AR-C69931MX + MRS2179 + LPA
 
22 ± 11
 
20 ± 12*
 


Aggregation, % light transmission

Control
Aspirin
LPA, 30 μM   80 ± 5   73 ± 16  
AR-C69931MX + LPA   36 ± 16  33 ± 14* 
MRS2179 + LPA   41 ± 24*  32 ± 19* 
AR-C69931MX + MRS2179 + LPA
 
22 ± 11
 
20 ± 12*
 

Values are mean ± SD (n = 3).

Concentrations of platelet inhibitors were: aspirin, 1 mM; AR-C69931MX, 1 μM; MRS2179, 100 μM. LPA was 1-acyl-LPA (16:0).

*

P < .05

P < .01

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