Table 5.

Quality of life (SCL-90R) at first enrollment in HCV study

All HCV+ patients
All adult HCV+ patients
Adult HCV+ patients without cirrhosis*
Question
n
%
n
%
n
%
Normative adult data (N = 974)
Unadjusted P†
Nausea or upset stomach   108   27.8   80   31.3   71   25.4   22.7   .679  
Pains in heart or chest   110   20.9   81   22.2   72   22.2   16.2   .225  
Headaches   110   54.5   81   55.6   72   55.6   54.8   .995  
Pains in lower back   110   47.3   81   54.3   72   51.4   37.0   .018  
Muscle aches or soreness   110   46.4   81   54.3   72   52.8   29.9   < .001‡ 
Feeling low in energy   110   62.7   81   67.9   72   66.7   51.5   .013‡ 
Trouble concentrating   110   36.4   81   39.5   72   34.7   27.2   .197  
Trouble remembering things   110   53.6   81   58.0   72   56.9   42.3   .017  
Mind going blank   110   37.3   81   44.4   72   43.1   15.8   < .001‡ 
Feeling depressed   110   38.2   81   42.0   72   40.3   32.6   .209  
Feeling no interest in things   110   30.0   81   30.9   72   27.8   19.3   .103  
Feeling tense or keyed up   108   46.3   79   55.7   70   52.9   47.8   .467  
Worrying too much about things   109   57.8   80   65.0   71   62.0   55.7   .345  
Crying easily   109   31.2   80   32.5   71   26.8   16.2   .032  
Feeling easily annoyed or irritated   108   49.1   79   48.1   70   42.9   56.8   .026  
Faintness or dizziness   108   20.4   79   21.5   70   18.6   17.2   .857  
Heart pounding or racing   108   19.4   79   21.5   70   20.0   20.0   .999  
Trouble getting breath   108   20.4   79   17.7   70   15.7   13.9   .761  
Decreased interest in sex
 		 88
 		 29.5
 		 73
 		 34.2
 		 65
 		 32.3
 		 21.1
 		 .047
 
All HCV+ patients
All adult HCV+ patients
Adult HCV+ patients without cirrhosis*
Question
n
%
n
%
n
%
Normative adult data (N = 974)
Unadjusted P†
Nausea or upset stomach   108   27.8   80   31.3   71   25.4   22.7   .679  
Pains in heart or chest   110   20.9   81   22.2   72   22.2   16.2   .225  
Headaches   110   54.5   81   55.6   72   55.6   54.8   .995  
Pains in lower back   110   47.3   81   54.3   72   51.4   37.0   .018  
Muscle aches or soreness   110   46.4   81   54.3   72   52.8   29.9   < .001‡ 
Feeling low in energy   110   62.7   81   67.9   72   66.7   51.5   .013‡ 
Trouble concentrating   110   36.4   81   39.5   72   34.7   27.2   .197  
Trouble remembering things   110   53.6   81   58.0   72   56.9   42.3   .017  
Mind going blank   110   37.3   81   44.4   72   43.1   15.8   < .001‡ 
Feeling depressed   110   38.2   81   42.0   72   40.3   32.6   .209  
Feeling no interest in things   110   30.0   81   30.9   72   27.8   19.3   .103  
Feeling tense or keyed up   108   46.3   79   55.7   70   52.9   47.8   .467  
Worrying too much about things   109   57.8   80   65.0   71   62.0   55.7   .345  
Crying easily   109   31.2   80   32.5   71   26.8   16.2   .032  
Feeling easily annoyed or irritated   108   49.1   79   48.1   70   42.9   56.8   .026  
Faintness or dizziness   108   20.4   79   21.5   70   18.6   17.2   .857  
Heart pounding or racing   108   19.4   79   21.5   70   20.0   20.0   .999  
Trouble getting breath   108   20.4   79   17.7   70   15.7   13.9   .761  
Decreased interest in sex
 		 88
 		 29.5
 		 73
 		 34.2
 		 65
 		 32.3
 		 21.1
 		 .047
 
*

Data from 7 patients with cirrhosis confirmed by biopsy and from one patient with clinically decompensated cirrhosis were removed

†

P values were based on exact binomial tests comparing results for adult HCV+ patients without cirrhosis with normative results considering the normative values as constant

‡

Individual P values less than .013 give a significant .10 study-wise alpha level based on the Holm multiple-comparison procedure

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal