Effect of sildenafil on CFR scores in the rabbit model of arterial thrombosis
Sildenafil dose, intravenously . | No. of animals achieving CFR scores of 0 . | No. of animals achieving CFR scores of 1 . | No. of animals achieving CFR scores of 2 . | No. of animals achieving CFR scores of 3 . |
|---|---|---|---|---|
| Vehicle | 3 | 1 | 0 | 0 |
| 0.01 mg/kg | 0 | 2 | 2 | 0 |
| 0.03 mg/kg* | 0 | 1 | 2 | 1 |
Sildenafil dose, intravenously . | No. of animals achieving CFR scores of 0 . | No. of animals achieving CFR scores of 1 . | No. of animals achieving CFR scores of 2 . | No. of animals achieving CFR scores of 3 . |
|---|---|---|---|---|
| Vehicle | 3 | 1 | 0 | 0 |
| 0.01 mg/kg | 0 | 2 | 2 | 0 |
| 0.03 mg/kg* | 0 | 1 | 2 | 1 |
The effect of treatment on CFR score was evaluated by a 2-sided permutation test.30 CFR scores correspond to the following: 0 indicates complete reduction of flow without spontaneous reversal; 1, reduction of flow with spontaneous reversal; 2, change in rate of flow reduction with spontaneous reversal; and 3, cessation of CFRs.
P < .05, 2-sided permutation test