Plasma LPL mass and activity, FVIII, VWF, and t-PA
Genotype . | LPL mass, ng/mL* . | LPL activity, μmol FFA/h/mL* . | FVIII, U/mL* . | VWF, U/mL* . | t-PA, ng/mL* . |
|---|---|---|---|---|---|
| Uninduced | |||||
| LRPflox/floxLDLR-/-APOE-/- | 19.6 ± 2.2 | 11.0 ± 1.4 | 1.8 ± 0.2 | 1.1 ± 0.1 | 1.0 ± 0.3 |
| MX1Cre+LRPflox/floxLDLR-/-APOE-/- | 21.3 ± 5.1 | 9.9 ± 1.6 | 2.0 ± 0.2 | 1.1 ± 0.3 | 1.2 ± 0.2 |
| pl:pC induced | |||||
| LRPflox/floxLDLR-/-APOE-/- | 19.1 ± 2.4 | 9.4 ± 0.9 | 1.9 ± 0.5 | 1.4 ± 0.3 | 0.9 ± 0.5 |
| MX1Cre+LRPflox/floxLDLR-/-APOE-/- | 71.2 ± 7.5‡ | 9.5 ± 1.7 | 4.4 ± 1.1‡ | 2.8 ± 0.6‡ | 1.7 ± 0.7‡ |
Genotype . | LPL mass, ng/mL* . | LPL activity, μmol FFA/h/mL* . | FVIII, U/mL* . | VWF, U/mL* . | t-PA, ng/mL* . |
|---|---|---|---|---|---|
| Uninduced | |||||
| LRPflox/floxLDLR-/-APOE-/- | 19.6 ± 2.2 | 11.0 ± 1.4 | 1.8 ± 0.2 | 1.1 ± 0.1 | 1.0 ± 0.3 |
| MX1Cre+LRPflox/floxLDLR-/-APOE-/- | 21.3 ± 5.1 | 9.9 ± 1.6 | 2.0 ± 0.2 | 1.1 ± 0.3 | 1.2 ± 0.2 |
| pl:pC induced | |||||
| LRPflox/floxLDLR-/-APOE-/- | 19.1 ± 2.4 | 9.4 ± 0.9 | 1.9 ± 0.5 | 1.4 ± 0.3 | 0.9 ± 0.5 |
| MX1Cre+LRPflox/floxLDLR-/-APOE-/- | 71.2 ± 7.5‡ | 9.5 ± 1.7 | 4.4 ± 1.1‡ | 2.8 ± 0.6‡ | 1.7 ± 0.7‡ |
Data are shown as mean ± SD. As determined at 4 weeks* and 12 weeks† after pl:pC injection.
P < .05, significantly different from LRPflox/floxLDLR-/-APOE-/- mice.