Composition of atherosclerotic lesions
Genotype . | LRPflox/floxLDLR-/-APOE-/- . | MX1Cre+LRPflox/floxLDLR-/-APOE-/- . |
|---|---|---|
| Total lesion area, 103μm2 | 219 ± 86 | 408 ± 115* |
| AIA-31240-positive area, % of total lesion area | 31.5 ± 9.7 | 29.3 ± 11.8 |
| 1A4-positive area, % of total lesion area | 25.3 ± 7.4 | 28.5 ± 12.2 |
| Non-AIA-31240- and non-1A4-positive area, % of total lesion area | 43.6 ± 9.1 | 43.4 ± 16.6 |
Genotype . | LRPflox/floxLDLR-/-APOE-/- . | MX1Cre+LRPflox/floxLDLR-/-APOE-/- . |
|---|---|---|
| Total lesion area, 103μm2 | 219 ± 86 | 408 ± 115* |
| AIA-31240-positive area, % of total lesion area | 31.5 ± 9.7 | 29.3 ± 11.8 |
| 1A4-positive area, % of total lesion area | 25.3 ± 7.4 | 28.5 ± 12.2 |
| Non-AIA-31240- and non-1A4-positive area, % of total lesion area | 43.6 ± 9.1 | 43.4 ± 16.6 |
Areas positively stained with AIA-31240 (macrophages) or 1A4 (smooth muscle cells) were quantified at the level of individual lesions ranging in size from 50 000 to 200 000 μm2 (11 individual lesions per group) and are expressed as percentages of total lesion area. Data are shown as mean ± SD.
P < .05, significantly different from LRPflox/floxLDLR-/-APOE-/- mice.