Table 2. Clinical findings in patients... | American Society of Hematology

Table 2.

Clinical findings in patients with family members with FE compared with those in unaffected family members

Organ system and clinical manifestations	Affected, n = 15	Unaffected, n = 16	P
Cardiac			NS†
Valvular disease^*	3	2
AV block	3	1	NS
Neurologic
Peripheral neuropathy	3	2	NS
TIA/cognitive decline	2	0	NS
Migraine	2	0	NS
Tremor	2	2	NS
Pulmonary
Obstructive disease	1	7	< .001
Skin
Psoriasis	1	2	NS
Psychiatric
Depression	2	2	NS
Ophthalmologic
Cortical cataracts	6	2	NS
Cortical vacuoles	4	4	NS
Nuclear cataracts	1	2	NS
Prior cataract surgery	1	2	NS
Any abnormality	12	10	NS

Organ system and clinical manifestations	Affected, n = 15	Unaffected, n = 16	P
Cardiac			NS†
Valvular disease^*	3	2
AV block	3	1	NS
Neurologic
Peripheral neuropathy	3	2	NS
TIA/cognitive decline	2	0	NS
Migraine	2	0	NS
Tremor	2	2	NS
Pulmonary
Obstructive disease	1	7	< .001
Skin
Psoriasis	1	2	NS
Psychiatric
Depression	2	2	NS
Ophthalmologic
Cortical cataracts	6	2	NS
Cortical vacuoles	4	4	NS
Nuclear cataracts	1	2	NS
Prior cataract surgery	1	2	NS
Any abnormality	12	10	NS

NS indicates not significant; AV, atrioventricular; and TIA, transient ischemic attack.

Defined as any structural abnormality of a valve seen on echocardiography or mild to severe regurgitant flow as assessed by Doppler

P > .1