CNS-reactive CD8+ T-cell responses in patients with MS and healthy subjects
Antigen . | RRMS, n (%) . | PPMS, n (%) . | SPMS, n (%) . | Healthy, n (%) . |
|---|---|---|---|---|
| Whole MBP | 5 (29) | 7 (35) | 0 (0) | 1 (13) |
| MBP mix | 7 (41) | 7 (35) | 0 (0) | 1 (13) |
| PLP mix 1 | 6 (35) | 4 (20) | 0 (0) | 2 (25) |
| PLP mix 2 | 7 (41) | 4 (20) | 1 (17) | 2 (25) |
| MOG-1 | 1 (6) | 0 (0) | 1 (17) | 1 (13) |
| MOG-2 | 3 (18) | 2 (10) | 1 (17) | 0 (0) |
| MOBP | 9 (53)† | 3 (15) | 1 (17) | 0 (0) |
| MAG-1 | 6 (35) | 6 (30) | 1 (17) | 3 (38) |
| MAG-2 | 3 (18) | 4 (20) | 1 (17) | 4 (50) |
| MAG-3 | 2 (12) | 1 (5) | 0 (0) | 1 (13) |
| OMGP-1 | 3 (18) | 3 (15) | 1 (17) | 5 (63) |
| OMGP-2 | 3 (18) | 5 (25) | 1 (17) | 1 (13) |
| CRAB | 0 (0) | 4 (20) | 1 (17) | 1 (13) |
| SB | 2 (12) | 1 (5) | 2 (33) | 0 (0) |
| CNP-1 | 5 (29) | 3 (15) | 4 (67) | 2 (25) |
| CNP-2 | 1 (6) | 0 (0) | 0 (0) | 0 (0) |
| SEB | 17 (100) | 20 (100) | 6 (100) | 8 (100) |
| Total patients | 15/17 (88) | 14/20 (70) | 5/6 (83) | 7/8 (88) |
| Total responses* | 63/255‡ (25) | 47/300 (16) | 15/90 (19) | 23/120 (19) |
Antigen . | RRMS, n (%) . | PPMS, n (%) . | SPMS, n (%) . | Healthy, n (%) . |
|---|---|---|---|---|
| Whole MBP | 5 (29) | 7 (35) | 0 (0) | 1 (13) |
| MBP mix | 7 (41) | 7 (35) | 0 (0) | 1 (13) |
| PLP mix 1 | 6 (35) | 4 (20) | 0 (0) | 2 (25) |
| PLP mix 2 | 7 (41) | 4 (20) | 1 (17) | 2 (25) |
| MOG-1 | 1 (6) | 0 (0) | 1 (17) | 1 (13) |
| MOG-2 | 3 (18) | 2 (10) | 1 (17) | 0 (0) |
| MOBP | 9 (53)† | 3 (15) | 1 (17) | 0 (0) |
| MAG-1 | 6 (35) | 6 (30) | 1 (17) | 3 (38) |
| MAG-2 | 3 (18) | 4 (20) | 1 (17) | 4 (50) |
| MAG-3 | 2 (12) | 1 (5) | 0 (0) | 1 (13) |
| OMGP-1 | 3 (18) | 3 (15) | 1 (17) | 5 (63) |
| OMGP-2 | 3 (18) | 5 (25) | 1 (17) | 1 (13) |
| CRAB | 0 (0) | 4 (20) | 1 (17) | 1 (13) |
| SB | 2 (12) | 1 (5) | 2 (33) | 0 (0) |
| CNP-1 | 5 (29) | 3 (15) | 4 (67) | 2 (25) |
| CNP-2 | 1 (6) | 0 (0) | 0 (0) | 0 (0) |
| SEB | 17 (100) | 20 (100) | 6 (100) | 8 (100) |
| Total patients | 15/17 (88) | 14/20 (70) | 5/6 (83) | 7/8 (88) |
| Total responses* | 63/255‡ (25) | 47/300 (16) | 15/90 (19) | 23/120 (19) |
The table shows the number of subjects from each group exhibiting a positive CD8+ T-cell response to the corresponding antigen. Total patient populations: RRMS, N = 17; PPMS, N = 20; SPMS, N = 6; and healthy subjects, N = 8.
Indicates the total number of positive responses to the peptide pools (out of a possible 15 for each subject).
Higher MOBP responses in RRMS, compared with healthy subjects (P < .05).
P < .01, compared with PPMS; P ~ .2, compared with healthy subjects.