Table 1. Clinical characteristics of the... | American Society of Hematology

Table 1.

Clinical characteristics of the MDS patients

	Age, y/sex		WBC count, × 10⁹/L	BM cytogenetics [% abnormal at diagnosis]	Source of injected cells	Progenitors/2 × 10⁶ cells			No. of human cells injected per mouse, × 10⁶
Patient no.	Age, y/sex		WBC count, × 10⁹/L	BM cytogenetics [% abnormal at diagnosis]	Source of injected cells	FAB			No. of human cells injected per mouse, × 10⁶	CFCs	LTC-ICs^*
1	67/M	RA	4	47,XY,+8[56];42-47,XY,+8,18q⁻, −21[42]	BM	1200	15	10-17
2	77/F	RARS	23	46,XX	BM	30	ND	4
3†	85/F	CMML	196	46,XX	PB	730	4	12, T depleted
4	65/M	CMML	16	46,XY	BM	700	4	10
5	67/M	CMML	248	46,XY	BM	1300	ND	13
6	71/M	CMML	5	45,X,-Y[100]	BM	ND	ND	10
7†	72/M	RAEB	2	46,XY	BM	520	7	15, T depleted
8	71/M	RAEB	7	46,XY,del(5q)(q13q33)[100]	PB	580	92	4
9	73/M	RAEBT	3	47,XY,+8[15]	BM	ND	ND	4
10†	63/M	RAEBT	10	46,XY	BM	590	36	15
11	37/F	RAEBT	5	47,XX,+8[48]	BM	610	5	7-10
Normal cells					lin-BM	400‡	150‡	0.4

	Age, y/sex		WBC count, × 10⁹/L	BM cytogenetics [% abnormal at diagnosis]	Source of injected cells	Progenitors/2 × 10⁶ cells			No. of human cells injected per mouse, × 10⁶
Patient no.	Age, y/sex		WBC count, × 10⁹/L	BM cytogenetics [% abnormal at diagnosis]	Source of injected cells	FAB			No. of human cells injected per mouse, × 10⁶	CFCs	LTC-ICs^*
1	67/M	RA	4	47,XY,+8[56];42-47,XY,+8,18q⁻, −21[42]	BM	1200	15	10-17
2	77/F	RARS	23	46,XX	BM	30	ND	4
3†	85/F	CMML	196	46,XX	PB	730	4	12, T depleted
4	65/M	CMML	16	46,XY	BM	700	4	10
5	67/M	CMML	248	46,XY	BM	1300	ND	13
6	71/M	CMML	5	45,X,-Y[100]	BM	ND	ND	10
7†	72/M	RAEB	2	46,XY	BM	520	7	15, T depleted
8	71/M	RAEB	7	46,XY,del(5q)(q13q33)[100]	PB	580	92	4
9	73/M	RAEBT	3	47,XY,+8[15]	BM	ND	ND	4
10†	63/M	RAEBT	10	46,XY	BM	590	36	15
11	37/F	RAEBT	5	47,XX,+8[48]	BM	610	5	7-10
Normal cells					lin-BM	400‡	150‡	0.4

FAB indicates French-American-British (classification); WBC, white blood cell; RA, refractory anemia; RARS, refractory anemia with ringed sideroblasts; ND, not done; CMML, chronic myelomonocytic leukemia; RAEB, refractory anemia with excess blasts; and RAEBT, refractory anemia with excess blasts in transformation.

Values shown are the number of CFCs produced by 2 × 10⁶ low-density BM or PB cells (as indicated) after 5 weeks in LTCs.

†

Separate aliquots transplanted on 2 or 3 different occasions.

‡

Values shown are the numbers of CFCs measured directly (CFCs) and after 6 weeks in LTCs (LTC-ICs) per 2 × 10³ lin⁻ normal BM cells.

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