Toxicities of hyper-CVAD and imatinib mesylate in 91 postinduction courses
. | No. (%)* . | . | |
|---|---|---|---|
| Parameter . | Grades 1-2 . | Grades 3-4 . | |
| Infections (overall)† | — | 23 (25) | |
| FUO | — | 7 (8) | |
| Pneumonia | — | 6 (7) | |
| Bacterial | — | 3 (3) | |
| Atypical | — | 2 (2) | |
| Fungal/presumed fungal | — | 1 (1) | |
| Sepsis | — | 9 (10) | |
| GNR bacteremia | — | 5 (5) | |
| Catheter-related bacteremia | — | 4 (4) | |
| Other | — | 8 (9) | |
| Sinusitis | — | 3 (3) | |
| Osteomyelitis | — | 2 (2) | |
| Herpes zoster | — | 2 (2) | |
| Upper respiratory infections (RSV) | — | 1 (1) | |
| Cardiovascular | |||
| Fluid retention | 5 (25) | 1 (5) | |
| Arrythmia (supraventricular) | 2 (10) | 2 (10) | |
| Deep venous thrombosis | — | 2 (10) | |
| Syncope | — | 2 (10) | |
| Reduction in ejection fraction | 2 (10) | — | |
| Hepatic | |||
| Increase in bilirubin | 5 (25) | — | |
| Increase in transaminases | 5 (25) | — | |
| Neuromuscular | |||
| Fatigue | 6 (30) | 2 (10) | |
| Peripheral neuropathy | 6 (30) | 1 (5) | |
| Headaches (postlumbar puncture) | 2 (10) | 2 (10) | |
| Bone pain | 3 (15) | — | |
| Myalgias | 2 (10) | — | |
| Fracture (femur/vertebral) | — | 2 (10) | |
| Gastrointestinal | |||
| Stomatitis | 5 (25) | — | |
| Constipation | 4 (20) | 1 (5) | |
| Diarrhea | 2 (10) | 2 (10) | |
| Nausea | 2 (10) | 1 (5) | |
| Reflux | 1 (5) | 2 (10) | |
| Ileus | — | 1 (5) | |
| Coagulopathy | |||
| Hypofibrinogenemia | 2 (10) | 1 (5) | |
| Hemorrhage | |||
| Gastrointestinal | — | 1 (5) | |
| Skin | |||
| Rash | 2 (10) | — | |
| Renal | |||
| Increase in creatinine | 5 (25) | — | |
| Hyponatremia | — | 1 (5) | |
. | No. (%)* . | . | |
|---|---|---|---|
| Parameter . | Grades 1-2 . | Grades 3-4 . | |
| Infections (overall)† | — | 23 (25) | |
| FUO | — | 7 (8) | |
| Pneumonia | — | 6 (7) | |
| Bacterial | — | 3 (3) | |
| Atypical | — | 2 (2) | |
| Fungal/presumed fungal | — | 1 (1) | |
| Sepsis | — | 9 (10) | |
| GNR bacteremia | — | 5 (5) | |
| Catheter-related bacteremia | — | 4 (4) | |
| Other | — | 8 (9) | |
| Sinusitis | — | 3 (3) | |
| Osteomyelitis | — | 2 (2) | |
| Herpes zoster | — | 2 (2) | |
| Upper respiratory infections (RSV) | — | 1 (1) | |
| Cardiovascular | |||
| Fluid retention | 5 (25) | 1 (5) | |
| Arrythmia (supraventricular) | 2 (10) | 2 (10) | |
| Deep venous thrombosis | — | 2 (10) | |
| Syncope | — | 2 (10) | |
| Reduction in ejection fraction | 2 (10) | — | |
| Hepatic | |||
| Increase in bilirubin | 5 (25) | — | |
| Increase in transaminases | 5 (25) | — | |
| Neuromuscular | |||
| Fatigue | 6 (30) | 2 (10) | |
| Peripheral neuropathy | 6 (30) | 1 (5) | |
| Headaches (postlumbar puncture) | 2 (10) | 2 (10) | |
| Bone pain | 3 (15) | — | |
| Myalgias | 2 (10) | — | |
| Fracture (femur/vertebral) | — | 2 (10) | |
| Gastrointestinal | |||
| Stomatitis | 5 (25) | — | |
| Constipation | 4 (20) | 1 (5) | |
| Diarrhea | 2 (10) | 2 (10) | |
| Nausea | 2 (10) | 1 (5) | |
| Reflux | 1 (5) | 2 (10) | |
| Ileus | — | 1 (5) | |
| Coagulopathy | |||
| Hypofibrinogenemia | 2 (10) | 1 (5) | |
| Hemorrhage | |||
| Gastrointestinal | — | 1 (5) | |
| Skin | |||
| Rash | 2 (10) | — | |
| Renal | |||
| Increase in creatinine | 5 (25) | — | |
| Hyponatremia | — | 1 (5) | |