FLT3 mutations in 71 childhood ALL samples
Primary identification no. (% blasts in sample) . | Exon 14-15, nucleotide positions (% mutant alleles) . | Activation loop, mutation (% mutant alleles) . | Remission status . |
|---|---|---|---|
| Hyperdiploid ALL, more than 50 chromosomes (n = 25) | |||
| ALL-6 (88) | — | I836Δ (30) | CCR |
| ALL-7 (90) | — | D835Y (20) | CCR |
| ALL-12 (89) | Δ 1770-1784 plus GA1787A1788 - > GGG (30) | — | CCR |
| ALL-25 (95) | TTC1770-> TTA Δ 1771-1782 (15) | — | CCR |
| ALL-34 (22) | — | D835V (11) | CCR |
| ALL-24 (95) | Δ 1777-1779 (47) | — | Relapse |
| TEL/AML1 (n = 29) | CCR | ||
| ALL-68 (95) | 30bp ITD (5) | — | — |
| Other: 1 E2A/PBX, 2 pseudodiploid, 5 diploid (n = 8) | — | — | — |
| Cytogenetics not available (n = 9) | |||
| ALL-35 (35) | — | D835E (7) | CCR |
| ALL-19 (70) | — | I836Δ (10) | Relapse |
| ALL-21 (30) | Δ 1732-1734 plus 18-bp insertion* (18) | — | Relapse |
Primary identification no. (% blasts in sample) . | Exon 14-15, nucleotide positions (% mutant alleles) . | Activation loop, mutation (% mutant alleles) . | Remission status . |
|---|---|---|---|
| Hyperdiploid ALL, more than 50 chromosomes (n = 25) | |||
| ALL-6 (88) | — | I836Δ (30) | CCR |
| ALL-7 (90) | — | D835Y (20) | CCR |
| ALL-12 (89) | Δ 1770-1784 plus GA1787A1788 - > GGG (30) | — | CCR |
| ALL-25 (95) | TTC1770-> TTA Δ 1771-1782 (15) | — | CCR |
| ALL-34 (22) | — | D835V (11) | CCR |
| ALL-24 (95) | Δ 1777-1779 (47) | — | Relapse |
| TEL/AML1 (n = 29) | CCR | ||
| ALL-68 (95) | 30bp ITD (5) | — | — |
| Other: 1 E2A/PBX, 2 pseudodiploid, 5 diploid (n = 8) | — | — | — |
| Cytogenetics not available (n = 9) | |||
| ALL-35 (35) | — | D835E (7) | CCR |
| ALL-19 (70) | — | I836Δ (10) | Relapse |
| ALL-21 (30) | Δ 1732-1734 plus 18-bp insertion* (18) | — | Relapse |
Seventy-one ALL samples were assessed for the presence of mutations in the juxtamembrane and activation loop regions of FLT3. The cytogenetic abnormalities (when available) are noted. The types of FLT3 mutations either in the juxtamembrane region or in the activation loop are noted.
CCR indicates complete continuous remission. — indicates no motion.
The 18-bp insertion (AACTTAAGGAACCCACCA) is inserted 3′ to nucleotide 1731.